Table Of ContentSYPHILIS – RECOGNITION,
DESCRIPTION AND
DIAGNOSIS
Edited by Neuza S. Sato
Syphilis – Recognition, Description and Diagnosis
Edited by Neuza S. Sato
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2011 InTech
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Publishing Process Manager Mirna Cvijic
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Image Copyright Apostrophe, 2011. Used under license from Shutterstock.com
First published November, 2011
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Syphilis – Recognition, Description and Diagnosis, Edited by Neuza S. Sato
p. cm.
ISBN 978-953-307-554-9
free online editions of InTech
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Contents
Preface VII
Part 1 Treponema pallidum 1
Chapter 1 Recognition of Treponema pallidum
and Other Spirochetes by the Innate Immune System 3
Gunthard Stübs and Ralf R. Schumann
Chapter 2 Whole Genome Analyses of Treponemes: New Targets for
Strain- and Subspecies-Specific Molecular Diagnostics 19
David Šmajs, Lenka Mikalová, Darina Čejková,
Michal Strouhal, Marie Zobaníková, Petra Pospíšilová,
Steven J. Norris and George M. Weinstock
Part 2 Syphilis Disease 35
Chapter 3 History of Different Therapeutics
of Venereal Disease Before the Discovery of Penicillin 37
Judit Forrai
Chapter 4 Psychiatric Manifestations of Neurosyphilis 59
Fabian Friedrich and Martin Aigner
Chapter 5 Spatial and Temporal Patterns of Primary Syphilis
and Secondary Syphilis in Shenzhen, China 71
Tiejian Feng, Yufeng Hu, Xiaobing Wu and Fuchang Hong
Part 3 Syphilis – Laboratorial Diagnosis 85
Chapter 6 Laboratorial Diagnosis of Syphilis 87
Neuza Satomi Sato
Chapter 7 Serologic Response to Treatment in Syphilis 109
Neuza Satomi Sato
Chapter 8 Syphilis and Blood Safety in Developing Countries 123
Claude Tayou Tagny
Preface
Syphilis, a sexually transmitted disease was first described in 15th century. It is caused
by Treponema pallidum subsp. pallidum, it occurs worldwide and it remains an
important health problem.
This book collects chapters which present novel knowledge about the T. pallidum, some
historical aspects of venereal disease and up to date information about syphilis disease.
First section includes chapters 1 and 2, which deal with novel knowledge of T.
pallidum: The immunologic recognition of the etiologic agent of syphilis (T. pallidum)
by the pattern recognition receptors of the innate immune system, and the
identification of new targets for molecular diagnosis of T.pallidum by analysis of
treponeme whole genome.
Second section includes chapters 3, 4 and 5, which present some information about
Syphilis Disease: A historical aspects of venereal diseases treatment, a clinical aspects
dealing with psychiatric manifestations of neurosyphilis and spatial and temporal
patterns of primary syphilis and secondary syphilis described by the spatial and
space-time scan statistics.
Finally, the last section includes chapters 6, 7 and 8, which mainly deal with laboratorial
diagnosis of syphilis. A review of methods commonly used for laboratorial diagnosis,
the serological response to treatment of syphilis and safety in blood transfusion.
I would like to thank each of the authors of the chapters, who took their great efforts in
writing the articles, and sharing their knowledge, expertise and ideas for this book.
I wish to express my gratitude to Ms. Mirna Cvijic, InTech Publishing Process
Manager, for her constant assistance and support during all phases of preparation of
this book. I would also like to thank very much to Ms. Viktorija Zgela, editorial
consultant at InTech, who contacted me to take over the editorial task of this project.
I am also indebted to InTech and its staff for the accomplishment of this book project.
Dr. Neuza Satomi Sato
Center of Immunology,
Institute Adolfo Lutz
São Paulo, SP
Brazil
Part 1
Treponema pallidum
