Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II

266 Pages·2016·7.636 MB·English

by  Maria Cristina Cuturi, Ignacio Anegon (eds.)

Methods in
Molecular Biology 1371
Maria Cristina Cuturi
Ignacio Anegon Editors
Suppression and
Regulation of
Immune Responses
Methods and Protocols
Volume II
M M B
ETHODS IN OLECULAR IOLOGY
Series Editor
John M. Walker
School of Life and Medical Sciences
University of Hertfordshire
Hat fi eld, Hertfordshire, AL10 9AB, UK
For further volumes:
http://www.springer.com/series/7651

Suppression and Regulation
of Immune Responses
Methods and Protocols, Volume II
Edited by
Maria Cristina Cuturi and Ignacio Anegon
INSERM UMR 1064-ITUN, Nantes, France
Editors
Maria Cristina Cuturi Ignacio Anegon
INSERM UMR 1064-ITUN INSERM UMR 1064-ITUN
Nantes, France Nantes, F rance
ISSN 1064-3745 ISSN 1940-6029 (electronic)
Methods in Molecular Biology
ISBN 978-1-4939-3138-5 ISBN 978-1-4939-3139-2 (eBook)
DOI 10.1007/978-1-4939-3139-2
Library of Congress Control Number: 2010936185
Springer New York Heidelberg Dordrecht London
© Springer Science+Business Media New York 2 016
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Dedication
Al Pepe Mujica, ejemplo de explorador de nuevos caminos.

Prefa ce
New Roads for Immune Tolerance: Finding the Way
Caminante no hay camino, se hace camino al andar.
Antonio Machado
This book describes new ways to induce immune immunoregulation and tolerance. The
epigraph underlines that the roads taken in research are not defi ned in advance and unwind
whilst moving ahead. This may seem obvious but underscores some interesting points of
present research. One is that basic research, without a fi nal goal or a given objective but
rather curiosity-driven, needs to be preserved and stimulated as a way to fi nd new paths of
progress. Another point is the need to have a very open mind to options that emerge during
research and fi nd the one that may seem the most appropriate to choose. Finally, once on
the road to immunoregulation or immune tolerance as a goal, the trail may be long winded
and dangerous.
The aim of this book is a guide to fi nding roads, walking along them whilst making
choices fi nding objectives in immunoregulation and immune tolerance research and avoid-
ing making the same mistakes. These aims are based on recent developments on cells and
molecules of the immune system and their interactions. This volume II on “Suppression
and Regulation of Immune Responses” follows the one published in 2009. All of the chap-
ters of this volume II are entirely new and describe research on new areas from researchers
with worldwide recognition and extensive experience in their topics.
We believe that the book will be of interest and inspirational for new research in immune
tolerance, and we hope that future readers will fi nd it useful. We are very grateful to the
authors that made this book possible; they are the intrepid travelers on these research roads.
Nantes, France Maria C ristina C uturi
Ignacio Anegon
vii

Acknowledgments
We gratefully acknowledge Mrs. Brenda Evans for her very effi cient secretarial assistance.
We also acknowledge support by the project IMBIO-DCs from de Région Pays de la Loire,
the Labex IGO project (n° ANR-11-LABX-0016-01) funded by the “Investissements
d’Avenir” French Government program, managed by the French National Research Agency
(ANR) and by the project Institut Hospitalo Universitaire-Centre Européen des Sciences
de la Transplantation et d’Immunothérapie (CESTI) funded by the “Investissements
d’Avenir” French Government program (n° ANR-10-IBHU-005) as well as by Nantes
Metropole and the Pays de la Loire Region, the ONE Study funded by the European
Union FP7 program and the Fondation ProGreffe.
ix