Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion: Proceedings of the Second International Conference on: “Structure and Function of Molecules Involved in Leukocyte Adhesion II”

410 Pages·1993·10.34 MB·English

by  Nancy Hogg

Structure, Function, and Regulation of
Molecules Involved in Leukocyte Adhesion
Proceedings of the Second International Conference on:
"Structure and Function of Molecules
Involved in Leukocyte Adhesion II"
Held in Titisee, Germany
October 2-6, 1991
Co-Chairpersons:
Peter E. Lipsky, M.D.
C. Wayne Smith, M.D.
P.E. Lipsky R. Rothlein T.K. Kishimoto
R.B. Faanes C.W. Smith
Editors
Structure, Function,
and Regulation of
Molecules Involved in
Leukocyte Adhesion
With 131 Illustrations
Springer-Verlag
New York Berlin Heidelberg London Paris
Tokyo Hong Kong Barcelona Budapest
Peter E. Lipsky, M.D. Robert Rothlein, Ph.D.
Professor, Internal Medicine and Microbiology Distinguished Scientist
University of Texas Cellular Adhesion!lmmunology;
Southwestern Medical Center at Dallas Takashi Kei Kishimoto, Ph.D.
5323 Harry Hines Blvd. Senior Scientist
Dallas, TX 75235-8884 Cellular Adhesion!lmmunology;
Ronald B. Faanes, Ph.D.
C. Wayne Smith, M.D. Director, R&D Scientific and Technical Operations
Professor, Department of Pediatrics Boehringer Ingelheirn Pharmaceuticals, Inc.
Leukocyte Biology Section 900 Ridgebury Road, Box 368
Texas Children's Hospital Ridgefield, CT 06877-0368
Clinical Care Center, Suite 1130
6621 Fannin. MC 3-3272
Houston, TX 77030-2399
Cover Art: see Figure 5.6 for description
Library of Congress Cataloging-in-Publication Data
International Conference on "Structure and Function of Molecules
Involved in Leukocyte Adhesion II" (1991 : Titisee, Germany)
Structure, function, and regulation of molecules involved in
leukocyte adhesion: proceedings of the Second International
Conferences on "Structure and Function of Molecules Involved in
Leukocyte Adhesion II," held in Titisee, Germany, October 2-6,1991
/ eds., Peter E. Lipsky ... [et al.).
p. cm.
Includes bibliographical references.
ISBN-13: 978-1-4613-9268-2 e-ISBN-13: 978-1-4613-9266-8
DOl: 10.1007/978-1-4613-9266-8
1. Leucocytes-Congresses. 2. Cell adhesion-Congresses.
I. Title.
[DNLM: 1. Cell Adhesion Molecules-immunology-congresses.
2. Cell Adhesion Molecules-physiology-congresses. 3. Integrins
physiology-congresses. 4. Leukocytes-physiology-congresses.
5. Lymphocyte Transformation-physiology-congresses. OW 573 1602s
1991)
ORI85.8.L48I65 1991
616.07'9-dc20
DNLMlDLC
for Library of Congress 92-2337
Printed on acid-free paper.
© 1993 Springer-Verlag New York, Inc.
Softcover reprint of the hardcover I st edition 1993
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Production managed by Karen Phillips; manufacturing supervised by Vincent Scelta.
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98765 4 321
Acknowledgments
The editors are indebted to Ms. Leah Neumaier for her organizational
and administrative contributions to the preparation of the symposium and
this pUblication. Professor Alan S. Rosenthal, Sr. Vice President of Sci
entific and Medical Affairs, BIPI USA, and Professor Franz Waldeck,
Member of the Corporate Board and Head of Research and Develop
ment BI GmbH, are acknowledged for their foresight in supporting re
search activities which set the stage for the Second Titisee Symposium on
Leukocyte Adhesion Biology. The contributions of Doctors of Philos
ophy, Hermann Frohlich and Ms. Ingeborg Wernicke of the Boehringer
Fonds in facilitating the arrangement of accommodations and special
events at the Schwarzwald, which made the meeting a memorable occa
sion, cannot go unnoticed.

Participants
Donald Anderson, Andrea Apperl, Randall Barton, Anthony Berendt,
Franz Birke, Barbara-Jean Bormann, Eric Brown, Robert Colvin, A.
Benedict Cosimi, Nava Dana, Laurie Davis, Ronald Faanes, Carl Figdor,
Alain Fischer, Herman Frohlich, Michael Gallatin, Johanna Griffin,
Robert Gundel, Rupert Hallmann, Rudy Hammer, Dorian Haskard,
Herbert Hechtman, Martin Hemler, Martin Hofmann, Nancy Hogg,
Larry Husten, Mark Jutila, Geoffrey Kansas, Joachim Kaysser, Marcus
Kehrli, Marilyn Kehry, Kei Kishimoto, Gordon Letts, Peter Lipsky,
Steven Marlin, Stephan Martin, Rodger McEver, Ira Mellman, James
Neuberger, Leah Neumaier, Nancy Oppenheimer-Marks, Laurie Phillips,
Louis Picker, Martyn Robinson, Steven Rosen, Robert Rothlein, Francis
co Sanchez-Madrid, Linda Scharschmidt, Michael Schaude, Elke
Seewaldt-Becker, C. Wayne Smith, Roger Snow, Donald Staunton,
Lloyd Stoolman, Peter Swetiy, Robert Wallace, Ingeborg Wernicke, and
Robert Winn.
Contents
Acknowledgments ................................................ v
Participants ..................................... . . . . . . . . . . . . . . . . . .
VII
Contributors ...................................................... xiii
Introduction ...................................................... xxiii
Part 1: Structure and Function of the Integrins
1. Leukocyte Integrin Activation ................................ 3
Nancy Hogg, Carlos Cabanas, and Ian Dransfield
2. Activation of LFA-1: Role of Cations ......................... 14
Carl G. Figdor and Yvette van Kooyk
3. An Antibody that Promotes Adhesion Events Mediated by
Both LFA-1 and CR3 ......................................... 25
Martyn K. Robinson, David Andrew, Hugh Rosen, Derek
Brown, Susan Ortlepp, P. Stephens, and Eugene C. Butcher
4. Function of a Soluble Human {Q Integrin CDllb/CD18 ...... .. 34
Nava Dana, Dehmani M. Fathallah, and M. Amin Arnaout
5. Mac-l (CDllb/CD18) and Adherence-Dependent Neutrophil
Locomotion .................................................. 45
B.l. Hughes, J. C. Hollers, and C. Wayne Smith
6. Functional Comparison ofthe Integrins a4{31 (VLA-4) and a4{37 58
Bosco M. C. Chan, Mariano J. Elices, and Martin E. Hemler
7. Functional Mapping and Regulation of VLA-4
Adhesion Activities ....................................... . . . . 67
Francisco Sanchez-Madrid, Rafael Pulido, Antonio A. Postigo,
Miguel R. Campanero, Alicia G. Arroyo, Rosario Garda-
Vicuna, Armando Laff6n, and Manuel O. de Landazuri
8. Signal Transduction Through a Novel Phagocyte Integrin 78
Eric J. Brown and Hattie D. Gresham
ix
x Contents
9. Interactions of the Plasmodium falciparum-Infected
Erythrocyte With ICAM-1 .................................... 92
Anthony R. Berendt, Alison McDowall, Alister G. Craig,
Paul A. Bates, Christopher 1. Newbold, and Nancy Hogg
Part 2: Structure and Function of the Selectins
10. The Selectins ................................................. 107
Takashi Kei Kishimoto
11. Leukocyte Interactions Mediated by P-Selectin ................ 135
Rodger McEver
12. PMN Extravasation in Acute Inflammation: A Role for Selectin
Interaction in Initial PMN-Endothelial Cell Recognition ...... 151
Louis J. Picker, Ulrich H. von Andrian, Alan R. Burns,
Claire M. Doerschuk, Karl-E. Arfors, and Eugene C. Butcher
13. Interaction of LAM-l With an Inducible Ligand Supports
Leukocyte Adhesion to Endothelium. . . . . . . . . . . . . . . . . . . . . . . . . . 168
Geoffrey S. Kansas, Olivier Spertini, Francis W. Luscinskas,
Michael Gimbrone, and Thomas F. Tedder
14. The Contribution of L-Selectin to Leukocyte Trafficking
In Vivo....................................................... 182
Bruce Walcheck and Mark L. Jutila
15. L-Selectin as a Mediator of Leukocyte Binding to
Myelinated Tracts of the Central Nervous System: Possible
Pathophysiologic Significance ................................. 191
Steven D. Rosen and Kun Huang
16. Selectin-Dependent Monocyte Adhesion in Frozen Sections of
Rheumatoid Synovitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200
L.M. Stoolman, J. Grober, B. Bowen, P. Reddy, J. Shih,
C. Thompson, D.A. Fox, and H. Ebling
Part 3: Cell Biology of Adhesion Molecules
17. Fc Receptor Function and Cytoplasmic Domain
Heterogeneity ................................................ 217
Ira Mellman
18. ~egulation of Antigen-Independent Adhesion of
CD4 T Cells .................................................. 228
Fabienne Mazerolles, F. Amblard, O. Lecomte, S. Meloche,
C. Barbat, P. Hauss, C. Hivroz, R. Sekaly and A. Fischer
19. The Adhesion and Transendothelial Migration of Human T
Lymphocytes ................................................. 232
Nancy Oppenheimer-Marks, Peter Pietschmann,
Laurie S. Davis, John J. Cush, Arthur F. Kavanaugh, and
Peter E. Lipsky
Contents xi
20. Changes in Topography of Cell Adhesion Molecules During
Lymphocyte Migration Across Endothelium ................... 242
Stephen J. Rosenman, Patricia A. Hoffman, and
W. Michael Gallatin
21. Cytokines and the Control of Endothelial Cell Adhesiveness for
Leukocytes in Inflammation ................................ . .. 251
Dorian O. Haskard and Martin H. Thornhill
22. Co-stimulation of T-Lymphocyte Activation by Adhesion
Molecules .................................................... 256
Laurie S. Davis and Peter E. Lipsky
Part 4: In Vivo Models
23. The Role of CDllaJCD18-CD54 Interactions in the Evolution
of Animal Models of Tissue Injury ............................ 273
Peter E. Lipsky, Hugo E. Jasin, Ellis Lightfoot, and
William J. Mileski
24. Mechanisms and Consequences of Leukocyte Adhesion...... .. 279
Robert K. Winn, Sam R. Sharar, William J. Mileski,
Charles L. Rice, and John M. Harlan
25. The Role of Cellular Adhesion Molecules in Acute and Chronic
Airway Inflammation ......................................... 291
Robert H. Gundel, Craig D. Wegner and L. Gordon Letts
26. Adhesion Molecules in the Shwartzman Response 306
Lawrence W. Argenbright and Randall W. Barton
27. Clinical and Immunological Features Associated With Bovine
Leukocyte Adhesion Deficiency. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 314
Marcus E. Kehrli Jr., Dale E. Shuster, Mark Ackermann,
C. Wayne Smith, Donald C. Anderson, Monique Dore, and
Bonnie J. Hughes
28. The Role of Leukocyte Adhesion Molecules During Ischemia
and Reperfusion .............................................. 328
Thomas F. Lindsay, James Hill, C.R. Valeri, D. Shepro, and
Herbert B. Hechtman
Part 5: Clinical
29. Abnormalities of LECAM-1- and MAC-1-Dependent
Neutrophil-Endothelial Cell Adhesion in the Developing
Host.......................................................... 337
Donald C. Anderson, Omid Abbassi, James D. Fortenberry,
Joyce Koenig, and C. Wayne Smith
30. Expression of ICAM-1 in Human Liver ....................... 356
James Neuberger, David Adams, and Stefan Hubscher