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Structure-based Drug Discovery PDF

255 Pages·2007·18.419 MB·English
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by Harren Jhoti (Editor), Andrew Leach (Editor)| 2007| 255 pages| 18.419| English

About Structure-based Drug Discovery

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as we as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications. This book is an invaluable resource for medicinal chemists in industry, computational chemists, drug discovery scientists and postgraduates in chemistry or structural biology.

Detailed Information

Author:Harren Jhoti (Editor), Andrew Leach (Editor)
Publication Year:2007
ISBN:9781402044069
Pages:255
Language:English
File Size:18.419
Format:PDF
Price:FREE
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