Structure and Function of the Neural Cell Adhesion Molecule NCAM

428 Pages·2010·8.07 MB·English

by  Vladislav Soroka

BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011
Structure and Function of the Neural Cell Adhesion
Molecule NCAM
BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011

ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IruN r. CoHEN, The Weizmann Institute of Science
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
JoHN D. LAMBrIS, University of Pennsylvania
roDoLFo PAoLETTI, University of Milan
For other titles published in the series, go to
www.springer.com/series/5584
BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011
Vladimir Berezin
Editor
Structure and Function
of the Neural Cell Adhesion
Molecule NCAM
BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011
Editor
Vladimir Berezin
Department of Neuroscience and Pharmacology
Panum Institute
university of Copenhagen
Copenhagen N, Denmark
[email protected]
ISBN 978-1-4419-1169-8 e-ISBN 978-1-4419-1170-4
DoI 10.1007/978-1-4419-1170-4
Springer New York Dordrecht Heidelberg London
Library of Congress Control Number: 2009942988
© Springer Science+Business Media, LLC 2010
All rights reserved. This work may not be translated or copied in whole or in part without the written
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The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are
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to proprietary rights.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011
Preface
Dr. Elisabeth Bock (Photo Keenpress)
This book contains review articles that produce a snapshot of recent developments
in the field of the neural cell adhesion molecule NCAM. The chapters are grouped
into sections reflecting various aspects of NCAM structure and function. The
themes cover the structural basis of cell adhesion mediated by NCAM and NCAM
interaction partners, NCAM-mediated signaling determinants of NCAM function
under physiological conditions and in disease, and the therapeutic potential of
NCAM mimetics.
Section 1, “Structure and Ligands of NCAM,” introduces the reader to the struc-
tural basis of NCAM-mediated cell adhesion, discussing the current knowledge of
extracellular and intracellular NCAM ligands and the structural basis of NCAM inter-
actions with the fibroblast growth factor (FGF) receptor. Section 2, “NCAM and
Polysialic Acid,” focuses on NCAM polysialylation, discussing the structural and
functional aspects of the most important posttranslational modifications of NCAM by
the addition of a long linear homopolymer of sialic acid to the fifth Ig-like NCAM
module. Section 3, “NCAM-mediated Signal Transduction,” is devoted to signal
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vi Preface
transduction mechanisms associated with NCAM-mediated adhesion, with a focus on
signaling pathways involved in NCAM-mediated neurite outgrowth, the role of
growth-associated proteins, signaling through lipid microdomains, and signaling
crosstalk with the epidermal growth factor (EGF) receptor. Section 4, “NCAM
Metabolism,” focuses on current knowledge about NCAM biosynthesis and the gen-
eration and role of soluble NCAM. Section 5, “NCAM, Synapses, Emotions, and
Memory,” describes the role of NCAM in spine dynamics, synaptogenesis, and learn-
ing and memory. Section 6, “NCAM in Disease,” covers the role of NCAM in neu-
ropsychiatric disorders, neurodegenerative disorders, and cancer. Section 7,
“Pharmacology of NCAM: NCAM Mimetics,” reviews current achievements in the
in vivo and in vitro pharmacology of small NCAM mimetic peptides. Section 8,
“orthologs and Paralogs of NCAM,” discusses current knowledge about the structure
and function of the NCAM ortholog Fasciclin II and the NCAM paralog NCAM2.
The concluding section is devoted to Professor Elisabeth Bock, to whom this
book is dedicated. Prof. Bock in the early 1970s identified the neural cell adhesion
molecule NCAM as brain specific protein D2 (published in Journal of
Neurochemistry, 1974, vol. 23, pp. 879–880). She has dedicated her professional
career to the characterization of this very important and intriguing molecule.
I would like to thank everyone who has contributed to this book by writing
review articles on various aspects of NCAM structure and function, Kristine
Immediato for her kind assistance in managing the manuscripts, and Michael
Arends for his professional proofreading of a number of the manuscripts. I would
also like to acknowledge the European union-supported Integrated Project
ProMEMorIA, which since 2005 has been a staunch supporter of NCAM-related
research.
Denmark Vladimir Berezin
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Contents
Part I Structure and Ligands of NCAM
Structural Biology of NCAM ......................................................................... 3
Vladislav Soroka, Christina Kasper, and Flemming M. Poulsen
Extracellular Protein Interactions Mediated by the Neural Cell
Adhesion Molecule, NCAM: Heterophilic Interactions Between
NCAM and Cell Adhesion Molecules, Extracellular Matrix
Proteins, and Viruses ...................................................................................... 23
Janne Nielsen, Nikolaj Kulahin, and Peter S. Walmod
Intracelluar Ligands of NCAM ..................................................................... 55
Bettina Büttner and rüdiger Horstkorte
NCAM and the FGF-Receptor ...................................................................... 67
Vladislav V. Kiselyov
The Role of ATP in the Regulation of NCAM Function .............................. 81
Martin V. Hübschmann and Galina Skladchikova
Part II NCAM and Polysialic Acid
Polysialylation of NCAM ................................................................................ 95
Herbert Hildebrandt, Martina Mühlenhoff, and rita Gerardy-Schahn
Structural Basis for the Polysialylation of the Neural Cell
Adhesion Molecule .......................................................................................... 111
Karen J. Colley
The Role of PSA-NCAM in Adult Neurogenesis .......................................... 127
Eduardo Gascon, Laszlo Vutskits, and Jozsef Zoltan Kiss
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viii Contents
Use of PSA-NCAM in Repair of the Central Nervous System ................... 137
Abderrahman El Maarouf and urs rutishauser
Part III NCAM-Mediated Signal Transduction
Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth ....... 151
Dorte Kornerup Ditlevsen and Kateryna Kolkova
Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated
Neurite Outgrowth .......................................................................................... 169
Irina Korshunova and Mark Mosevitsky
The Neural Cell Adhesion Molecule NCAM and Lipid Rafts .................... 183
Gro Klitgaard Povlsen and Dorte Kornerup Ditlevsen
The Neural Cell Adhesion Molecule and Epidermal Growth
Factor Receptor: Signaling Crosstalk ........................................................... 199
Gro Klitgaard Povlsen
Part IV NCAM Metabolism
Biosynthesis of NCAM .................................................................................... 213
Kateryna Kolkova
Soluble NCAM ................................................................................................ 227
Thomas Secher
Part V NCAM, Synapses, Emotions, and Memory
Role of NCAM in Spine Dynamics and Synaptogenesis .............................. 245
D. Muller, P. Mendez, M. Deroo, P. Klauser, S. Steen, and L. Poglia
NCAM in Long-Term Potentiation and Learning ....................................... 257
Barbara P. Hartz and Lars Christian B. rønn
Role of NCAM in Emotion and Learning ..................................................... 271
Lisa Conboy, reto Bisaz, Kamila Markram, and Carmen Sandi
Part VI NCAM in Disease
NCAM in Neuropsychiatric and Neurodegenerative Disorders ................. 299
Leann H. Brennaman and Patricia F. Maness
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Contents ix
Neural Cell Adhesion Molecule in Cancer: Expression
and Mechanisms .............................................................................................. 319
Silvia Zecchini and ugo Cavallaro
Part VII Pharmacology of NCAM: NCAM Mimetics
NCAM Mimetic Peptides: An Update ........................................................... 337
Vladimir Berezin and Elisabeth Bock
Synthetic NCAM-Derived Ligands of the Fibroblast Growth
Factor Receptor ............................................................................................... 355
Stine Maria Hansen, Shizhong Li, Elisabeth Bock, and Vladimir Berezin
Dendritic Spine and Synapse Morphological Alterations
Induced by a Neural Cell Adhesion Molecule Mimetic ............................... 373
Michael Stewart, Victor Popov, Nikolai Medvedev, Paul Gabbott,
Nicola Corbett, Igor Kraev, and Heather Davies
Part VIII Orthologs and Paralogs of NCAM
Fasciclin II: The NCAM Ortholog in Drosophila melanogaster ................. 387
Lars V. Kristiansen and Michael Hortsch
The Neural Cell Adhesion Molecule NCAM2/OCAM/
RNCAM, a Close Relative to NCAM ............................................................ 403
Nikolaj Kulahin and Peter S. Walmod
Part IX Conclusion
Honoring Dr. Elisabeth Bock ......................................................................... 423
Vladimir Berezin
Index ................................................................................................................. 427
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Contributors
Vladimir Berezin
Protein Laboratory, Department of Neuroscience and Pharmacology,
Panum Institute, university of Copenhagen, 24.2, Blegdamsvej 3, DK-2200,
Copenhagen N, Denmark
[email protected]
Reto Bisaz
Laboratory of Behavioral Genetics, Brain Mind Institute, EPFL,
Lausanne, Switzerland
Elisabeth Bock
Protein Laboratory, Department of Neuroscience and Pharmacology,
Faculty of Health Sciences, university of Copenhagen, Blegdamsvej 3C,
Building 6.2, Copenhagen, N, DK-2200, Denmark
[email protected]
Leann H. Brennaman
Department of Biochemistry and Biophysics, Silvio Conte Center for
Schizophrenia research, university of North Carolina School of Medicine,
Chapel Hill, NC 27599, uSA
Bettina Büttner
Institut für Physiologische Chemie, Martin-Luther-universität Halle-Wittenberg,
Hollystr.1, 06114 Halle, Germany
Ugo Cavallaro
IFoM, Via Adamello 16, I-20139 Milano, Italy
[email protected]
Karen J. Colley
Department of Biochemistry and Molecular Genetics,
university of Illinois College of Medicine, Chicago, IL, uSA
[email protected]
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