Stem Cell Biology in Neoplasms of the Central Nervous System

200 Pages·2015·3.404 MB·English

by  Moneeb Ehtesham (eds.)

Advances in Experimental Medicine and Biology 853
Moneeb Ehtesham Editor
Stem Cell Biology
in Neoplasms
of the Central
Nervous System
Advances in Experimental Medicine and Biology
VOLUME 853
Series Editors
Irun R. Cohen
TheWeizmann Institute of Science
Rehovot
Israel
N. S. Abel Lajtha
Kline Institute for Psychiatric Res
Orangeburg
NewYork
USA
Rodolfo Paoletti
University of Milan
Milan
Italy
John D. Lambris
Univ. Of Pennsylvania
Philadelphia
Pennsylvania
USA
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Moneeb Ehtesham
Editor
Stem Cell Biology
in Neoplasms of the Central
Nervous System
Editor
Moneeb Ehtesham
Department of Neurosurgery
Vanderbilt University Medical Center
Nashville , TN , USA
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-319-16536-3 ISBN 978-3-319-16537-0 (eBook)
DOI 10.1007/978-3-319-16537-0
Library of Congress Control Number: 2015937184
Springer Cham Heidelberg New York Dordrecht London
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To my juniors—J.A.M., A.M.M., S.L.Z., A.S.
No man could ask for a better team
in the heat of battle

Acknowledgements
A volume like this is beyond the scope of one person/editor’s effort. There are count-
less hours spent contacting authors, reviewing submissions, and cross-c hecking ref-
erences and publication permissions—tedious work that can be draining but remains
essential for a project like this to succeed. This project would have failed miserably
if it were not for the tireless effort and dedication of Imad Saeed Khan, M.D., whose
assistance in making this volume a reality is tremendously appreciated by me and all
those involved. Thank you, Imad, for your passion in helping make this idea a real-
ity. I would also like to thank Fiona Sarne, Joy Evangeline Bramble, and Sabina
Ashbaugh at Springer who, together, were always available to assist and shepherd
this project through, and whose help made this volume a pleasure to work on.
vii

Contents
Regulation of Subventricular Zone-Derived Cells Migration
in the Adult Brain............................................................................................ 1
Vivian Capilla-Gonzalez , Emily Lavell , Alfredo Quiñones-Hinojosa ,
and Hugo Guerrero-Cazares
The SVZ and Its Relationship to Stem Cell Based
Neuro-oncogenesis ........................................................................................... 23
Yael Kusne and Nader Sanai
Isolation and Characterization of Stem Cells from Human
Central Nervous System Malignancies ......................................................... 33
Imad Saeed Khan and Moneeb Ehtesham
The Role of Stem Cells in Pediatric Central Nervous
System Malignancies ....................................................................................... 49
Branavan Manoranjan , Neha Garg , David Bakhshinyan ,
and Sheila K. Singh
Laboratory Models for Central Nervous System Tumor
Stem Cell Research ......................................................................................... 69
Imad Saeed Khan and Moneeb Ehtesham
Radiation Therapy for Glioma Stem Cells ................................................... 85
Anthony E. Rizzo and Jennifer S. Yu
Chemoresistance and Chemotherapy Targeting Stem-Like Cells
in Malignant Glioma ....................................................................................... 111
Mia Dahl Sørensen , Sigurd Fosmark , Sofi e Hellwege , Dagmar Beier ,
Bjarne Winther Kristensen , and Christoph Patrick Beier
ix