Table Of ContentSTATISTICS IN MEDICINE VOL. 16, 2941-2943 (1996) 
AUTHOR INDEX 
Aalen, O. O., 2191  Chuang-Stein, C., 2599  Fleming, T. R., 1515 
ACSF Investigators, 397  Clark, I., 1745  Fuerst, T. P., 1889 
Agresti, A., 2599  Clark, L. C., 853 
Aickin, M., 1845  Cnaan, A., 2349  Gail, M., 133 
Akazawa, K., 583  Commenges, D., 1283  Gamel, J. W., 1629 
Andersen, P. K., 215  Connelly, R. R., 1401  Gao, S., 783, 2049, 2419 
Anderson, S., 44i  Cook, P., 321  Gatsonis, C., 2311 
Ashby, D., 1413  Cook, R. J., 911  Gee, L., 441 
Austin, H., 1005  Coste, J., 561  Gefeiler, O., 981, 1107 
Couper, D., 1551  Genant, H. K., 1889 
Bacchetti, P., 645  Crichton, N. J., 717  Gilks, W. R., 741 
Bailey, N. T. J., 2447  Cui, J.-S., 2339  Gill, O. N., 2191 
Barai, U.,.941  Cuzick, J., 1017  Gill, R., 39 
Becher, H., 993  Glidden, D. V., 833 
Becker, N. G., 2339  Dain, B., 1943  Glynn, R. J., 357 
B,l isle, P., 769  Daniels, M. J., 1965, 2311  Goldberg, R., 1311 
Benichou, J., 133  Dartiques, J., 1283  Goldbourt, U., 1873 
Bennett, C. L., 1451  Davidian, M., 1765  Gonin, R., 1925 
Bernardinelli, L., 741  Davis, C. E., 2009  Gordon-Salant, S., 2475 
Best, N. G., 741  Day, N. E., 2191  Gore, S. M., 2459 
Betensky, R. A., 465, 2429,  De Angelis, D., 2191  Gray,J .C ., 1481 
2587  De Angelis, R., 425  Greenland, S., 515 
Biggerstaff, B. J., 753  De Gruttola, V., 1515  Greenwood, C. M. T., 545 
Biscay, R., 1745  Dear, K. B. G., 2177  Grill, S. E., 2245 
Bixler, E. O., 1995  Deville, J.-C., 397  Gu, C., 1357 
Bjorling, L. E., 1175  Dey, D. K., 1817 
Blood, J., 681  Diehr, P., 1211  Haber, M., 601 
Bois, F. Y., 441  Dobson, A. J., 2177  Hadgu, A., 1391, 2403 
Boyett, J. M., 2095  Donner, A., 1097, 1753  Hakulinen, T., 2297 
Brant, L. J., 2475  Drescher, K., 117  Hall, W. J., 2143 
Brenner, H., 981  Du Berger, R., 769  Halpern, J., 153 
Breslow, N. E., 103  Dubey, S. D., 2529  Hamilton, S. A., 2029 
Brettle, R. P., 2459  Dunnett, C. W., 2489  Hanrahan, J. P., 1603 
Brittain, E., 681  Dunstan, F. J., 1481  Hardy, R. J., 2063 
Broemeling, L. D., 321  Dyba, T., 2297  Hashemi, L., 1311 
Brookmeyer, R., 1983  Hauck, W. W., 441, 545, 
Brown, B. W., 2511  Edwards, R., 1017  1683 
Brown, E. B., 803  Eliasziw, M., 1097  Heijde, D. van der, 1653 
Bull, K., 1041  Elswick, R. K., Jr., 1695  Heinze, G., 73 
Bull, S. B., 545  Erkanli, A., 1121  Heitjan, D. F., 347, 1791 
Byrne, C., 133  Etzioni, R., 627  Hinde, J. P., 717 
Hodges, J. S., 1175 
Cai, J., 2009  Fairclough, D. L., 1197  Hogan;J . W., 239, 259 
Capocaccia, R., 425  Faraggi, D., 2573  Holubkov, R., 103 
Carey, V. J., 1667  Farewell, V. T., 2191  Hosmer, D. W., 965 
Carroll, R. J., 169  Fatti, L. P., 333  Hosmer, T., 965 
Carter-Campbell, S., 695  Fay, M. P., 791, 2389  Hughes, M. D., 865, 1965 
Catalano, P. J., 883  Fayers, P. M., 1413  Hui, S., 1889 
Chen, L., 1167  Feuer, E. J., 791, 2389  Hui, S. L., 2419 
Chen, R., 1401, 1873  Fick, G. H., 373, 2103  Huque, M. F., 2529 
Chow, S.-C., 1031  Finkelstein, D. M., 951  Hyslop, T., 441
2942  AUTHOR INDEX 
Iscovich, J., 1873  Marchini, J., 717  Romano, P. S., 1301(L) 
Iyer, H. K., 803  Marshall, R., 2022(L)  Romanowski, B., 2103 
Martin, D. O., 1005  Rose, M. S., 373, 2103 
Jacqmin-Gadda, H., 1283  Martinussen, T., 273  Rosenberger, W. F., 2245 
Jereb, J. A., 485  Mathews, J. N. S., 705  Rosner, B., 357 
Jiang, W., 853  Mathur, A. K., 1889  Rotnitzky, A., 81 
Jim,nez, J. C., 1745  Matsuyama, Y., 1587  Russek-Cohen, E., 455 
Johnson, W. D., 1081, 2127  Matts, J. P., 1943  Russell, K., 2511 
Jones, B., 1955  May, W. L., 1081, 2127 
Joseph, L., 769  Mehrotra, D. V., 1465  Sankoh, A. J., 2529 
Meier, K. L., 1337  Schemper, M., 73 
Kaiser, M. S., 1151  Meisner, M., 2211  Schill, W., 117 
Keiding, N., 215, 273  Messiah, A., 397  Schmoor, C., 225 
Klar, N., 1753  Meyer, L., 397  Schoenfeld, D. A., 951 
Klein, B., 1357  Mian, I. U. H., 1497  Schumacher, M., 225 
Klein, J. P., 215  Miller, C., 1943  Schwartz, P. F., 1695 
Klein, R., 1357  Milner, P. C., 2117  Scott, A. J., 1377 
Klerk, E. de, 1653  Morrell, C. H., 2475  Seaman, S. R., 2459 
Knapp, R. G., 1705  Moy,, L. A., 2267  Segal, M. R., 1603 
Koch, G., 2403  Segnan, N., 1017 
Kiichenhoff, H., 169  Nakamura, T., 583  Senn, S., 1303(L), 2021(L) 
Kuha, J., 189  Nandram, B., 1311  Shao, J., 1031, 1167 
Neely Atkinson, E., 1803  Shapiro, D. E., 2143 
Lachin, J. M., 653  Nejjari, C., 1283  Sharma, D., 347 
Lagakos, S. W., 925  Nelson, E. T., 1943  Shen, Y., 627 
Laird, N. M., 239, 259, 2349  Neuh,,user, M., 993  Shih, W. J., 1225, 1913 
Langer, S. F. J., 1617  Ng'andu, N. H., 611  Shoukri, M. M., 1497 
Larose, D. T., 1817  Nix, A. B. J., 1481  Siev, D., 1151 
Laska, E. M., 2211  Simon, R., 2573 
Lau, T. S., 2283  Obuchowski, N. A., 1529  Simon, R. M., 455 
Launer, C. A., 1943  Ohashi, Y., 1587  Slasor, P., 2349 
Lawless, J. F., 911  Smith, P. J., 485 
Lazaridis, E. N., 1925  Paivarinta, L., 2297  Soltysik, R. C., 1451 
Le Cessie, S., 965  Palensky, J., 681  Soyer, R., 1121 
Leblond, L., 203  Palesch, Y., 583  Spiegelhalter, D. J., 1041 
Lee, A. J., 1377  Pan, G., 1645  Sposto, R., 695 
Lee, S. Y., 1859  Park, T., 1859  Stablein, D., 695 
Lee, W.-C., 729  Parmar, M. B., 1413  Stamenovic, E., 951 
Leisenring, W., 1263  Pascutto, C., 741  Stangl, D., 1121 
Lele, C., 2543  Patrick, D. L., 1211  Strémberg, U., 2327 
Lellouch, J., 397  Pearson, J. D., 2475  Sun, J., 497 
Lemeshow, S., 965  Pepe, M., 5 
Li, Q. H., 925  Pepe, M. S., 1263, 1551  Tager, I. B., 1603 
Li, Y., 2095  Perkins, L. L., 1005  Tamhane, A. C., 2489 
Lin, D. Y., 901, 1515  Pichlmeier, U., 1107  Tang, D.-I., 2211 
Linden, S. van der, 1653  Pitard, A., 527  Tango, T., 2621(L) 
Lindsey, J. K., 1955  Psaty, B. M., 1211  Ten Have, T. R., 1995 
Liu, Q., 711(L), 2095  Puterman, M. L., 2177  Teoh, N., 941 
Longton, G., 1263  Pyke, S. D. M., 2063  Terry Beirn Community 
Love, E. J., 2103  Programs for Clinical 
Lu, Y., 1889  Quan, H., 1225  Research on AIDS, 1943 
Lui, K.-J., 1777  Therneau, T. M., 2029 
Reilly, M., 5  Thompson, M. L., 333 
McClish, D. K., 1529  Reynolds, T., 1481  Thompson, S. G., 2063 
McKee, L. J., 1683  Richardson, S., 203  Thompson, T. J., 485 
Mackenzie, G., 1831  Ritov, Y., 285  Tibshirani, R., 385 
McMurchy, L., 1377  Robins, J., 81  Tierney, C., 2587 
McNeil, A. J., 2555  Robins, J. M., 21, 39, 285  Torrance-Rynard, V. L., 2157 
McShane, L. M., 1337  Roe, D. J., 1241  Tretli, S., 1435 
Mantel, N., 1401  Rogerson, P. A., 2081  Turnbull, B. W., 853
AUTHOR INDEX 
Turner, B. J., 1683  Walker, S., 1135  Wittes, J., 681 
Tweedie, R. L., 753  Wallenstein, S., 1329  Wolfe, D. A., 1645 
Walsh, S. J., 669  Xie, T., 1845 
Umbach, D. M., 1731  Walter, E., 561  Xue, X., 1983 
Urquhart, J., 1653  Walter, S. D., 2157 
Wang, C. M., 803  Yarnold, P. R., 1451 
Vacek, P. M., 505  Wang, Y., 1357  Ye, K., 1889 
Vach, W., 57  Warszawski, J., 397 
Varga, P., 821(L)  Wasserman, D., 561 
Venot, A., 561  Wassermann, E. M., 1337  Zackin, R., 571 
Viel, J. F., 527  Wei, L. J., 571, 833  Zahl, P.-H., 1435, 1573 
Vogel, R. L., 1629  Weinberg, C. R., 1731  Zeng, Q., 1765 
Voit, E. O., 1705  Welsh, J. A., 1695  Zhao, P.-L., 1913 
Vuorinen, J., 2229  Westrom, L., 2403  Zhou, H., 1301(L), 2009 
White, I. R., 2619(L)  Zhou, X., 783 
Wahba, G., 1357  Whittemore, A. S., 153, 2543  Zhou, X.-H., 2049 
Wakefield, J., 1135  Wight, S., 1603  Zou, K. H., 2143
STATISTICS IN MEDICINE, VOL. 16, 2945-2962 (1997) 
SUBJECT INDEX“ 
Notes: Single page numbers refer to individual papers. The page ranges shown indicate collections of 
papers on particular subjects. (L) after some page numbers identifies letters. 
Accident and emergency  Almon’s method, 527 
forecasting models, 2117  Analysis of variance 
longitudinal study, 2928  F tests, 2729 
Accrual buffers,  1925  intraclass correlations,  1497 
Accuracy  smoothing spline methods, 1357 
clinical trials, 705  Anderson-Gill model, 2029 
indices ROC curves,  1529  Anginal attacks, 1955 
Adenomatous polyps, 1845  Antigens, 1151 
Adjustment  non-parallel immunoassay curves,  1151 
multiple endpoints, 2529  Antiretroviral  therapy 
Age  rule-based ranking schemes, 1175 
breast cancer,  133, 1435  ARIMA see Autoregressive integrated moving 
data-dependent interval partition,  1617  averages 
Age-specific rates  Artherosclerosis see Coronary artery disease 
reference intervals, 2785  Assays 
AIDS (Acquired immunodeficiency syndrome)  cell dilution, 571 
see also CD4 lymphocyte counts; HIV  Association 
asymptotic period, 627  continuously monitored strategy, 1925 
clinical trials  Asthma 
endpoint, 951, 1175  treatment divergence, 2855 
surrogate markers,  1515, 1965  Asymptotic confidence intervals,  1329 
cumulative incidence function, 901  Asymptotic relative efficiency, 117 
delay data, 2339  Attributable risk 
follow-up losses, 1943  Bayesian inference, 1311 
incidence, 645  epidemiology, 729 
longitudinal studies, smooth curves, 2429  recurrent disease events, 1107 
Markov model analysis, 2191  risk factor prevalence, 2543 
pneumonia,  1451  Autoregressive integrated moving average models 
Air pollution, 2928  accident and emergency attendances, 2117 
Alcoholism  reparametrization,  1745 
diagnosis test, 1695 
Algorithms  Backcalculation 
see also Expectation maximization algorithm;  HIV diagnosis, 2191 
Markov Chain Monte Carlo algorithm  Baseline measurements 
CODA, 285  biased baseline rates, 1401 
LABROC4, 2143  heterogeneity, 2883 
Metropolis-Hasting algorithm,  1817  Bayesian inference 
ROC & ROL, 2143  autocorrelated errors, 321 
Allocation ratio sample size calculation, 2805  binomial proportions,  1311 
* Compiled by INDEXING SPECIALISTS,  202 Church Road, Hove, East Sussex, BN3 2DJ, U.K.
2946  SUBJECT INDEX 
Bayesian inference (cont.)  Bladder cancer, 865 
CODA asymptotic theory, 285  Blinded subjective ranking 
dose determination,  1135  treatment effect, 681 
hierarchical models  Blood pressure 
disease maps, 741  intraclass correlations,  1497 
variability analysis, 2311  missing data, 2713 
immunological progression rates, 2555  BMDP computer package 
independence models, chest pain diagnosis, 717  mixed models, 2349 
measurement errors, 203  Bone marrow 
meta-analysis,  1817  transplants 
persuasion probability, 1791  busulfan concentrations, 2095 
proportional hazards model, 2573  continuous monitoring,  1925 
sample sizes, 769  graft-versus-host disease, 1551 
treatment evaluation, 1803  Bone mineral density, 1889 
two-phase prevalence studies, 1121  Book reviews 
underlying risk, 2741  Agresti, A., An Introduction to Categorical Data 
Bayesian monitoring scheme  Analysis, 2383 
interim analysis, 1413  Arminger, G., Clogg, C. C. and Sobel, M. E., 
Bayes’ theorem, 1413  Handbook of Statistical Modeling for the 
Beta-binomial model, 2849  Social and Behavioural Sciences, 1433 
Bias  Armitage, P. and David, H. A., Advances in 
baseline rates,  1401  Biometry, 2137 
cutpoint model, 2813  Baker, F. B., Item Response Theory. Parameter 
diagnostic tests,  1391  Estimation Techniques, 2261 
measurement error,  169  Bell, F. D., Basic Statistics: Concepts for the 
model misspecification, 669  Health Sciences: The Almost No Math Stats 
observational studies, 1041  Book, 1307 
reduction, 545  Beolchi, L. and Kuhn, M. H., Medical Imaging- 
Binary response  Analysis of Multimodality 2D/3D Image, 
correlated data, 1081, 2127  2630 
double-blind clinical trials,  1913  Berry, D. A. and Stangl, D. K., Bayesian 
mixed effects models, 1587  Biostatistics,  1655 
randomized clinical trials, 1017  Bishop, C. M., Neural Networks for Pattern 
recurrent disease events, 1107  Recognition, 2385 
teratologic studies, 2843  Blond, M., An Introduction to Medical Statistics, 
two-stage data, 103  2262 
Binary screening tests, 2282  Bowers, D., Statistics from Scratch: An 
Binormal model ROC analysis, 669  Introduction for Health Care Professionals, 
Bioassays  2932 
non parallel dose-response curves,  1151  Breen, R., Regression Models: Censored, 
Bioavailability  Sample-Selected, or Truncated Data, 
bioequivalence, 803, 2229  1789 
replicate crossover designs, 1031  Buncher, C. R. and Tsay, J. Y., Statistics in the 
Biochemical markers, 1481  Pharmaceutical Industry (2nd edn), 1909 
Bioequivalence  Busby, C., Wings of Death: Nuclear Pollution 
higher-order cross-over designs, 1031, 2229  and Human Health, 2025 
individual, 803  Campbell, M. J. and Swinscow, T. D. V., 
population, 441  Statistics at Square One, 2629 
Biographies  Carroll, R. J., Ruppert, D. and Stefanski, L. A.., 
Semmelweis, I. P., 2767  Measurement Error in Nonlinear Models, 
Biostatistics  2628 
future trends, 2773  Chalmers, I. and Altman, D. G., Systematic 
Birthweight  Review, 2929 
logistic regression model, 965  Chatfield, C., The Analysis of Time Series - An 
maternal smoking, 1603  Introduction, 2386 
Bivariate data  Cleveland, W. S., The Elemants of Graphing 
discriminant analysis, 2679  Data, 481 
power approximation, 865  Clogg, C. C. and Shihadeh, E. S., Statistical
SUBJECT INDEX  2947 
Models for Ordinal Variables. Advanced  Kleinbaum, D. G., Survival Analysis: A Self- 
Quantitative Techniques in the Social  Learning Text, 2934 
Sciences 4483  Knapp, T. R., Learning Statistics Through 
Coggon, D., Statistics in Clinical Practice, 1193  Playing Cards, 1543 
Cooper, H. and Hedges, L. V., The Handbook of  Kreienbrock, L. and Schach, S., 
Research Synthesis, 713  Epidemiologische Methoden, 829 
Corter, J. E., Tree Models of Similarity and  Krzanowski, W. J., Recent Advances in 
Association,  1546  Descriptive Multivariate Analysis, 1787 
Di Rienzo, M., Mancia, G., Parati, G., Pedotti,  Lange, N., Ryan, L., Billard, L., Brillinger, D., 
A. and Zanchetti, A., Computer Analysis of  Conquest, L. and Greenhouse, J., Case 
Cardiovascular Signals, 1195  Studies in Biometry, 963 
Eerola, M., Probabilistic Causality in  Lehtonen, R. and Pahkinen, E. J., Practical 
Longitudinal Studies, 2761  Methods for Design and Analysis of 
Esteve, J., Benhamou, E. and Raymond, L.,  Complex Surveys, 482 
Statistical Methods in Cancer Research.  McNeil, D., Epidemiological Research Methods, 
Vol IV. Descriptive Epidemiology, 715  2381 
Everitt, B. S., The Cambridge Dictionary of  Manton, K.G., Woodbury, M. A. and Tolley, 
Statistics in the Medical Sciences, 1910  H.D., Statistical Applications Using Fuzzy 
Feinstein, A. R., Multivariate Analysis: An  Sets, 1789 
Introduction, 2382  Marubini, E. and Valsecchi, M. G., Analysing 
Finkel, S. E., Causal Analysis with Panel Data,  Survival Data from Clinical Trials and 
1547  Observational Studies, 2138 
Fischer, G. H. and Molenaar, I. W., Rasch  Matthews, J. R., Quantification and the Quest for 
Models. Foundations, Recent Developments  Medical Certainty, 1908 
and Applications, 1431  Meinert, C. L., Clinical Trials Dictionary: 
Forthofer, R. N. and Lee, E. S., Introduction to  Terminology and Usage Recommendations, 
Biostatistics.  A Guide to Design, Analysis,  1911 
and Discovery, 1075  Mollison, D. (ed), Epidemic Models: Their 
Gabler, E., Biometrische Methodik  Structure and Relation to Data, 1666 
Pharmakologischer Tierexperimente, 2139  Moore, T. J., Deadly Medicine: Why Tens of 
Glasbey, C. A. and Horgan, G. W., Image  Thousands of Patients Died in America’s 
Analysis for the Biclogical Sciences, 2759  Worst Drug Disaster, 2507 
Goldstein, H., Multilevel Statistical Models (2nd  O’Hagan, A., Kendall’s Advanced Theory of 
edn), 1309  Statistics.  Volume 2B, 1907 
Grayson, Lesley, Scientific Deception: An  Paling, J., Up To Your Armpits in Alligators? 
Overview and Guide to the literature  How To Sort Out What Risks Are Worth 
of Misconduct and Fraud in Scientific  Worrying About!, 2929 
Research, 599  Parmar, M. B. K. and Machin, D., Survival 
Greenwood,  P. E. and Nikulin, M. S.,  A Guide to  Analysis: A Practical Approach, 714 
Chi-squared Testing, 2263  Peto, R., Lopez, A. D., Boreham, J., Thun, M. 
Haccou, P. and Meelis, E., Statistical Analysis of  and Heath, C. Jr., Mortality from Smoking 
Behavioural Data - An Approach Based on  in Developed Countries, 1544 
Time-structured Models, 1079  Rasch, D., Tiku, M. L. and Sumpf, D., Elsevier’s 
Hampton, R. E., Introductory Biological  Dictionary of Biometry, 1080 
Statistics,  1308  Rees, D. G., Essential Statistics for Medical 
Hand, D. and Crowder, M., Practical  Practice - A Case-Study Approach, 1194 
Longitudinal Data Analysis, 2026  Selvin, Steve, Practical Biostatistical Methods, 
Hayduk, L. A., LISREL - Issues, Debates, and  600 
Strategies, 1911  Sloan, M. D., Using Designed Experiments to 
Hill, C., Com-Nougué, C., Kramar, A., Moreau,  Shrink Health Care Costs, 2627 
T., O’Quigley, J., Senoussi, R. and  Stapleton, J. H., Linear Statistical Models, 1076 
Chastang, C., Analyse Statistique des  Strike, P., MEDSAP. A Statistical Toolkit for 
Données de Survie, 1550  Health Professionals Version 22265 
Hoch, J. C. and Stern, A. S., NMR Data  Thall, P., Recent Advances in Clinical Trial 
Processing, 2935  Design and Analysis, 1077 
Isham, V. and Medley, G., Models for Infectious  Utts, J. M., Seeing Through Statistics, 2931 
Human Diseases: Their Structure and  Venables, W. N. and Ripley, B. D., Modern 
Relation to Data, 1545  Applied Statistics with S-PLUS, 1548
2948  SUBJECT INDEX 
Book reviews (cont.)  Carryover effects 
Verma, B. L., Shukla, G. D. and Srivastava, R.  replicate crossover designs, 1031 
N., Biostatistics: Perspectives in Health  CART see Classification and regression tree. . . 
Care Research and Practice, 825  Case-control studies 
Viertl, R., Statistical Methods for Non-Precise  colorectal cancer, 1845 
Data, 1194  data re-using, 1377 
Wallgren, A., Wallgren, B., Persson, R., Jorner,  early stopping, 2327 
U. and Haaland, J-A., Graphing Statistics  genotype/exposure independence, 1731 
and Data, 2760  meta-analysis, 1005 
Weir, B. S., Human Identification:  The Use of  post-hoc stratification, 993 
DNA Markers, 828  relative attributable risk, 2543 
Bootstrap  two-stage methods,  103, 117, 133 
directly standardized rates, 791  Categorical data 
log-normal means, 783  latent variable model, 883 
resampling technique, 2813  CD4 lymphocyte counts 
Breast cancer  see also AIDS; HIV 
asymptomatic period, 627  HIV, marker, 1965 
chemotherapy trials,  1629  pre-AIDS mortality, 2459 
DNA flow cytometry, 2813  progression rates, 2555 
exposure-specific rates, 133  Centile estimates 
long-term survival, 1435  multivariate approach, 333 
prognostic markers, 2573  Change-score analysis, 1211 
quality of life analysis, 1197  Chemotherapy 
radiation effect, 21, 39  chemoimmunotherapy trial, 11803 
Breast implants, 1005  survival analysis, 1629 
British Family Heart study, 2063  Chest conditions 
Bronchitis  pain diagnosis, 717 
dust concentration,  169  Chlamydia trachomatis,  1391 
BUGS computer package, 2741  Cholesterol 
Burkitt’s lymphoma, 2081  repeated measurements analysis, 653 
Chronic diseases 
CABG see Coronary artery bypass grafting  non-fatal recurrent events, 1831 
Calcium level, 1587  recurrent/terminating events, 911, 925 
Calibration  Classification 
comparative study, 1889  method comparison studies, 705 
immunoassay curves,  1765  optimal discriminant analysis, 561, 1451 
CAN see Consistent and asymptotically normal. . .  Classification and regression tree (CART) 
Cancer  technique, 717 
see also Breast cancer  Classification tree analysis (CTA), 1451 
asymptomatic period, 627  Clinical trials 
Bayesian interim analyses, 1791  see also Randomization; Stopping rules 
case-control studies, 993  AIDS, failure time, 951 
data monitoring,  1413  Bayesian analysis, monitoring,  1413 
incidence prediction, 2297  binary response studies, 1913 
mortality, occupational, 505, 515  contamination,  1017 
phase III clinical trials, 1845  continuous monitoring strategy, 1925 
prevalence, 425  data monitoring,  1413 
quality of life assessment, 1197  drop-outs, treatment comparison, 1225 
survival analysis, excess hazards, 1573  endpoints study, 1175, 1197, 2267 
three-stage designs, 2701  follow-up losses, #943 
Canonical systems, 1705  health status, 1197, 1211 
Cardiac data processing, 1617  heterogeneity, 583, 2009 
Cardiology  HIV, recurrent/terminating events, 925 
variability analysis, 2311  incomplete covariate data workshop, 1-319 
Cardiovascular diseases  interval-censored data, 497 
clinical trials, 2267  losses to follow-up, 1943 
risk, frailty model, 1983  multiple endpoints, 2529 
risk factors, 1983  multiple events data, 833-951
SUBJECT INDEX 
multivariate time-to-event data, 865  Computers 
phase II  correlated data analysis, 2349 
Bayesian interim analysis, 1791  observational studies, 1667 
three-stage design, 2701  Conditional models 
stopping rules, 465, 1925  ectopic pregnancy, 2403 
treatment efficacy, 1017  measurement errors, 203 
treatment interaction,  1645  Conditional power calculations, 465 
Cluster analysis  Confidence intervals 
bivariate model, 883  binomial proportions, 1329 
leukaemia,  1873  correlated proportions, 2127 
naturally ordered individuals,  1617  directly standardized rates, 791 
teratologic studies, 2843  first event ocurrence, 711-712(L) 
Cluster randomization  log-normal means, 783 
community interaction trials, 1753  longitudinal studies, 2429 
mean hazard ratio parameters, 2009  qualitative interaction test, 1645  ‘ 
meta-analysis, 2063  quality performance index, 1301—1303(L) 
CODA see Curse of dimensionality. . .  treatment evaluation, 1017 
Cohort studies  vital rates, 2389 
two-stage sampling, 133  Confounders 
Collinearity  logistic regression model, 993 
pollutants/climatic conditions, 527  Confounding 
Colorectal cancer  attributable risk, 1107 
adenomatous polyps ocurrence,  1845  Connective tissue disease, 1005 
Combination  Consistent and asymptotically normal estimators 
across study designs, 1005  (CAN), 81 
treatments, 2211  Contamination 
Community interventions  fish, 2327 
pair-matched design, 1753  soils, 1167 
Community Programs for Clinical Research on  Continence status, 1859 
AIDS, 1175  Contingency tables 
Comparative calibration model, 1889  dose-response studies, 2599 
Comparative studies  Continuation ratio model 
binomial probabilities, 1329  ordinal responses, 2873 
discordant classification, 705  Continuity correction 
dropouts, 1225  confidence intervals,  1329 
goodness-of-fit tests, 965  exact equivalence tests, 1777 
proportional hazards assesment, 611  Yates’, 1329 
quality of life trials, 1197  Continuous confounders case-control studies, 993 
sets/cuscore techniques, 1401  Continuous data 
spatial prediction techniques, 1337  multivariate analysis, 883 
treatment effects, 1645  sample size, 2805 
variance components estimators,  1465  Continuous exposures, 729 
Competing risks  Continuous monitoring,  1925 
cumulative incidence functions, 901  Coronary artery bypass grafting (CABG), 2645, 
mortality, multivariate data, 951  2829 
Complete cases  Coronary artery disease 
estimates, 57  statistical models, 2829 
Complex survey data, 2419  Corrections 
Compliance  multiple testing, 2511, 2529 
drug dosing histories,  1653  Corrections to published papers, 479, 480, 1299- 
randomized clinical trials, 1017  1300, 2927-8 
Computer packages  Correlated frailty model, 1573 
see also SAS...  Correlations 
goodness-of-fit, 965  binomial proportions, 1081, 1587, 2127 
MEMS, 1653  generalized linear mixed model, 2349 
multivariate  failure time data, 2049  geographical distribution,  1283 
NONMEM,  1135, 1241  intraclass coefficient, 821-823(L) 
SPSS-PC, 1041  measurement errors, 2177
2950  SUBJECT INDEX 
Cortical maps, 1337  interval censoring, 485, 497 
Counting process  longitudinal, 239, 259, 273, 2429 
recurrent event analysis, 2029  net-work based mapping, 1667 
Covariates  skewness, 2785 
incomplete data  survival analysis, 1629 
drop-outs, 239, 259, 273  validation, 189, 203 
hot-deck multiple imputation, 5  Data monitoring committees (DMCs) 
measurement errors,  169, 189, 203, 741, 853  interim analyses, 1413 
multi-stage studies, 153  Data re-using, 1377 
non-response models, 21, 39, 81  Decision thesholds, 669 
prognostic factors, 57, 73, 225  Delay distribution, 2339 
two-stage studies, 103, 117  Dementia studies, 2419 
logistic regression, 1695  Depression 
missing values, complex survey data, 2419  prevalence in adolescents, 1121 
multivariate  failure time data, 2049  Designs 
Coverage probability  see also Two-stage design 
continuity correction,  1329  paired cluster randomization, 2063 
mean confidence intervals, 783  phase II trials, 2701 
Cox proportional hazards model  tolerance intervals, 803 
see also Non-proportional hazards model  Detection rates screening, 1481 
canonical system derivation,  1705  Developmental toxicity studies, 883 
confidence intervals, 783  Diabetes 
heterogeneity, 583  cortical cataract, 357 
incomplete covariate data, 21, 73, 225  disease mapping, 741 
multiple event data, 951  retinopathy, risk factors, 1357 
multivariate failure time, 833  Diagnosis 
multivariate time-to-event data, 865  AIDS, Markov model, 2191 
proportional hazards assumption, 611, 1831  alcoholism,  1695 
surrogate marker, 1515  CART methodology, 717 
variable selection, 385  clustering, 1873 
CPCRA see Community Programs for Clinical  tests 
Research on AIDS  accuracy, 1529 
Cross-validation  bias effect, 1391 
cutpoint model, 2813  dependent errors, 2157 
Crossover trials  disease, prevalence estimation, 981 
bioequivalence study, 803  marginal regression model, 1263 
higher-order designs, 2229  model misspecification, 669 
phase III, 2021-2022(L)  ROC curves, 2143 
treatment comparisons, 1031  Diet 
treatment-patient interactions,  1955  risk factors reduction, 2127 
CTA see Classification tree analysis  Directly standardized rates, 791 
Cumulative incidence  Discrepant analysis, 1391 
AIDS, 2459  Discrete time survival data, 1983 
competing risks, 901  Discriminant analysis 
Cumulative meta-analyses, 2901  classification tree analysis, 1451 
Cumulative sum method  ordinal responses, 561 
surveillance, spatial patterns, 2081  sum of binary variables, 2679 
Curse of dimensionality appropiate (CODA)  Diseases 
asymptotic theory, 285  mapping, 741, 2773 
Cuscore technique  DNA 
biased baseline rates, 1401  amplification tests, 1391 
Cytomegalovirus disease, 1263  U.S. blacks genes, 153 
Dose 
Data augmentation, 189, 653  data analysis, 1653 
Data collection  Dose-response 
clustering, 357  initial dose selection, 1135 
failure time, 215, 259, 497, 833, 841  non-parallel immunoassay curves, 1151 
follow-up data, 2773  ordinal responses, 2599