Table Of Content’
Spencer s Pathology of the Lung
Sixth Edition
’
Spencer s Pathology of
the Lung
Sixth Edition
Edited by
PhilipHasleton,MDFRCPath
ProfessorofPathology,UniversityofManchester,UK,andVisitingProfessorofPathology,HebrewUniversity,HaddasahMedicalSchool,Jerusalem,Israel
and
DouglasB.Flieder,MD
ProfessorofPathology,FoxChaseCancerCenter,Philadelphia,PA,USA
CAMBRIDGEUNIVERSITYPRESS
Cambridge,NewYork,Melbourne,Madrid,CapeTown,
Singapore,SãoPaulo,Delhi,MexicoCity
Cambridge University Press, United VRG
The Edinburgh Building, Cambridge CB2 8RU, UK
PublishedintheUnitedStatesofAmerica
byCambridgeUniversityPress,NewYork
www.cambridge.org
Informationonthistitle:www.cambridge.org/9780521509954
Sixthedition©CambridgeUniversityPress2013
LegacymaterialbyHerbertSpencer
©TheEstateofthelateHerbertSpencer2013
First,Second,Third,FourthandFiftheditions
©TheMcGraw-HillCompaniesInc.1962,1968,1977,1985,1996
Thispublicationisincopyright.Subjecttostatutoryexception
andtotheprovisionsofrelevantcollectivelicensingagreements,
noreproductionofanypartmaytakeplacewithout
thewrittenpermissionofCambridgeUniversityPress.
Sixtheditionfirstpublished2013
PrintedandboundintheUnitedKingdombytheMPGBooksGroup
AcataloguerecordforthispublicationisavailablefromtheBritishLibrary
LibraryofCongressCataloging-in-PublicationData
Spencer’spathologyofthelung.–6thed./editedbyPhilipHasleton,DouglasB.Flieder.
p.;cm.
Pathologyofthelung
Includesbibliographicalreferencesandindex.
ISBN978-0-521-50995-4(set:Hardback)–ISBN978-1-107-02433-5
(volume 1 : Hardback) – ISBN 978-1-107-02434-2 (volume 2 : Hardback)
I. Hasleton, P. S. II. Flieder, Douglas B. III. Spencer, United VRG, Herbert,
1915– Pathology of the lung. IV. Title: Pathology of the lung.
[DNLM:1. LungDiseases–pathology. 2. Lung–pathology. 3. LungDiseases–diagnosis.
WF600]
616.20407–dc23
2011046214
TwovolumesetISBN978-0-521-50995-4Hardback
Volume1 ISBN978-1-107-02433-5Hardback
Volume2 ISBN978-1-107-02434-2Hardback
CambridgeUniversityPresshasnoresponsibilityforthepersistenceor
accuracyofURLsforexternalorthird-partyinternetwebsitesreferredto
inthispublication,anddoesnotguaranteethatanycontentonsuch
websitesis,orwillremain,accurateorappropriate.
AllmaterialcontainedwithintheCD-ROMisprotectedbycopyright
andotherintellectualpropertylaws.Thecustomeracquiresonlythe
righttousetheCD-ROManddoesnotacquireanyotherrights,express
orimplied,unlessthesearestatedexplicitlyinaseparatelicence.
Everyefforthasbeenmadeinpreparingthisbooktoprovideaccurateand
up-to-dateinformationwhichisinaccordwithacceptedstandardsand
practiceatthetimeofpublication.Althoughcasehistoriesaredrawnfrom
actualcases,everyefforthasbeenmadetodisguisetheidentitiesofthe
individualsinvolved.Nevertheless,theauthors,editorsandpublisherscan
makenowarrantiesthattheinformationcontainedhereinistotallyfree
fromerror,notleastbecauseclinicalstandardsareconstantlychanging
throughresearchandregulation.Theauthors,editorsandpublishers
thereforedisclaimallliabilityfordirectorconsequentialdamagesresulting
fromtheuseofmaterialcontainedinthisbook.Readersarestrongly
advisedtopaycarefulattentiontoinformationprovidedbythemanufacturer
ofanydrugsorequipmentthattheyplantouse.
PSH
To my wife for her infinite patience and understanding and to my
childrenand grandchildren, whom Ihope to now see more often.
DBF
To my wonderful parentsSally andBilland truly exceptional wife Rita.
For my terrific children Anna and Jonny.
Contents
List of contributors ix
Forewordtothe First Edition xiv
Preface to theSixth Edition xv
Acknowledgements xvi
Volume 1 11. Metabolic andinherited connective tissue disorders
involving the lung 409
1. The normal lung: histology,embryology, Gail Amir andAnnickRaas-Rothschild
development, aging and function 1
12. Hypersensitivitypneumonitis 439
Neil Sahasrabudhe, John R.Gosney
John C. English
and Philip Hasleton
2. Lung specimen handling andpractical 13. Sarcoidosis 475
considerations 41 Douglas B. Flieder,Abraham Sanders
and MichaelN.Koss
Leslie Anne Litzky and Anthony Gal
3. Congenital abnormalities and pediatric 14. Occupational lung disease 512
lung diseases, including neoplasms 66 ThomasSpornandVictor L. Roggli
StephenJ.Gould,A.K. Webb and Anna Kelsey 15. Eosinophilic lung disease 563
4. Pulmonary bacterial infections 146 HenryD. Tazelaar,Joanne L. Wright and Jay H. Ryu
Mark Woodhead, Mary Klassen-Fischer, 16. Drug- and therapy-induced lung injury 585
Ronald C.Neafie,Ann-Marie Nelson,JeffreyR.Galvin Mary Beth Beasley andGlennA. Rudner
and Teri J. Franks
17. Chronic obstructive pulmonarydisease anddiseases
5. Pulmonary viralinfections 182 of the airways 605
RichardL. Kradin and Jay Fishman Wim Timens,Hannie SietsmaandJoanneL.Wright
6. Pulmonary mycobacterial infections 206 18. Pulmonary vascular pathology 661
LucianeDreher Irion and Mark Woodhead KatrienGrünbergand Wolter J. Mooi
7. Pulmonary mycotic infections 226 19. Pulmonary vasculitisand pulmonaryhemorrhage
Said Khayyata, Caroline B. Moore,Malcolm D. syndromes 711
Richardson, Philip Hasleton and CarolFarver EugeneJ. Mark, Rex Neal Smith,John H. Stone,
8. Pulmonary parasitic infections 288 Douglas B. Flieder,Amita Sharma and
Osamu Matsubara
Sebastian Lucas, Philip Hasleton, Ann-Marie Nelson
and Ronald C.Neafie 20. The pathology of lung transplantation 767
9. Acute lung injury 342 Gerald J.Berry and Helen M. Doran
William A.H. Wallace,A. John Simpson andNikHirani 21. The lungs in connective tissue disease 804
10. Interstitial lung diseases 366 DonaldG. GuineeJr.and William D.Travis
AndrewG. Nicholson and Alexandra J.Rice
vii
Contents
Volume 2 30. Salivary gland neoplasmsof the lung 1127
Sanja Dacic,Sebastian Gilbert,Iclal Ocak and
22. Benignepithelialneoplasms and tumor-like Joan Lacomis
proliferations of the lung 847
31. Neuroendocrinetumorsand other neuroendocrine
Douglas B. Flieder
proliferations of the lung 1151
23. Pulmonary pre-invasive disease 889 John R.Gosney
Keith M. Kerr
32. Sarcomatoid carcinomas and variants 1186
24. Epidemiological andclinical aspects Yukio Nakatani, Kenzo Hiroshima and EugeneJ. Mark
of lung cancer 945
33. Mesenchymaland miscellaneousneoplasms 1224
Erik Thunnissen, Michael Unger
Timothy C.Allen,Philip T.Cagle and
and Douglas B. Flieder
Douglas B. Flieder
25. Lung cancerstaging 1004
34. Pulmonary lymphoproliferative diseases 1316
Eric Lim andPeterGoldstraw
Bruce J.Addis
26. Immunohistochemistryin the diagnosis of
pulmonary tumors 1015 35. Metastases involving the lungs 1375
Bruno Murer,Marco Chilosi,Philip Hasleton
Paul William Bishop
and Douglas B. Flieder
27. Adenocarcinoma of the lung 1043
36. Diseases of the pleura 1408
Douglas B. Flieder,Alain C.Borczuk
Philip Hasleton,Francoise Galateau-Salle,Juliet King,
and Masayuki Noguchi
GiulioRossi,SylvieLantuejoul,Rebecca Preston,
28. Squamous cellcarcinoma ofthe lung 1093 DurgeshN.Rana and Godfrey Wilson
Douglas B. Fliederand ElisabethBrambilla
29. Large cell carcinoma and adenosquamous
carcinoma ofthe lung 1114
SylvieLantuejoul,MichèleFior-Gozlan,GilbertR.Ferretti Index 1565
and Denis Moro-Sibilot
viii
