SPECT and SPECT/CT: A Clinical Guide

220 Pages·2017·24.663 MB·English

by  Chun Kim, Katherine Zukotynski

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SPECT and SPECT/CT
A Clinical Guide
Chun K. Kim , MD
Clinical Director, Division of Nuclear Medicine and Molecular Imaging
Department of Radiology
Brigham and Women’s Hospital
Associate Professor of Radiology
Harvard Medical School
Boston, Massachusetts
Katherine A. Zukotynski, MD
Associate Professor
Departments of Radiology and Medicine
McMaster University
Hamilton, Ontario, Canada
250 illustrations
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Cont ent s
Preface
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii
Acknowledgments
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Contributors
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x
I The Fundamentals
1 Basic Principles of SPECT and SPECT/CT and Quality Control
. . . . . . . . . . . . . . . . . . . . . . . . 3
Frederic H. Fahey
2 Radiopharmaceuticals for Clinical SPECT Studies
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
Shankar Vallabhajoshula
II Clinical Applications
3 SPECT and SPECT/CT in Neuroscience
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Tarun Singhal and Chun K. Kim
4 SPECT/CT for the Thyroid and Parathyroid Glands with Cases
. . . . . . . . . . . . . . . . . . . . . 48
Elisa Franquet-Elía and Kevin J. Donohoe
5 SPECT and SPECT/CT for the Cardiovascular System
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74
Stephen J. Horgan and Sharmila Dorbala
6 SPECT and SPECT/CT for the Respiratory System
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92
Paul J. Roach and Geo rey P. Schembri
7 SPECT and SPECT/CT in Neoplastic Disease
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114
Katherine A. Zukotynski, Victor H. Gerbaudo, and Chun K. Kim
8 SPECT and SPECT/CT for the Skeletal System
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Hyewon Hyun, Chun K. Kim, and Katherine A. Zukotynski
9 SPECT/CT for Infection and Inflammation
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Christopher J. Palestro
10 SPECT in Children
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164
Frederick D. Grant
11 Selected Interesting SPECT and SPECT/CT Cases
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181
Samuel E. Almodóvar, Padma Manapragada, Katherine A. Zukotynski, and Chun K. Kim
Index
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198
vii
Pre face
With the advent ofhybrid imaging,the eld ofnuclear glands, the cardiovascular system, the respiratory
medicine has evolved signi cantly in recent years. In system, neoplastic disease, the skeletal system, infec-
particular, single-photon emission computed tomog- tion/ in ammation, and pediatrics. Illustrative case
raphy (SPECT) and SPECT/CT have come into their examples focusing on each clinical area are included
own as important diagnostic tools in routine clinical throughout the chapters. The nal chapter of this
practice. Indeed, SPECT and SPECT/CT are often tou- book presents a compilation of interesting cases tar-
ted as game changers in the way clinical nuclear geting topics not otherwise reviewed in the preceding
medicine is performed today. When we initially con- chapters.
sidered writing this book, we realized there were We have tried to write a book that is a concise,
several books available covering the general topics easy-to-read review of SPECT and SPECT/CT as it is
of nuclear medicine and PET. However, we felt there currently used in the clinic. Information is presented
was a lack of a concise book discussing the utility of in an accessible format with concise bullet points
SPECTand SPECT/CTin the imaging eld and that this highlighting key imaging ndings and teaching pearls
could be helpful primarily to residents, technologists throughout. We do not intend for this book to be a
and practicing physicians. comprehensive reference on the topic; rather, we
The goal of this book is to address a timely clinical hope it will provide a strong foundation, improved
need by providing a basic yet broad understanding of understanding ofthese techniques,and focused high-
and practical approach to SPECT and SPECT/CT that yield material for successful clinical practice in the
will be useful to a spectrum ofclinicians and technol- world of today.
ogists.The book begins with two chapters focusing on Leading experts in the eld ofhybrid imaging have
the technological foundation of SPECT and SPECT/CT contributed to this book,and it is a pleasure to feature
as well as the radiochemistry used in association with their work. We hope that you will enjoy reading our
these imaging techniques. This is followed by nine book and that you will nd it to be a valuable addition
chapters, each of which details the utility of SPECT to your library as well as a tool that will further your
and SPECT/CTfor imaging in a speci cclinicalcontext, success!
including neuroscience, the thyroid and parathyroid
viii