Table Of ContentPET
Positron Emission Tomography
With Correlative CT and MR
Bennett
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PET
Positron Emission Tomography
With Correlative CT and MR
Paige Bennett, MD
Associate Professor
Nuclear Medicine and Molecular Imaging
Department of Radiology
Wake Forest School of Medicine
Winston-Salem, North Carolina
Akiva Mintz, MD, PhD, MHA, CFA
Professor and Vice Chair of Translational Research, Radiology
Director, PET Center
Division Chief, Nuclear Medicine and Molecular Imaging
Department of Radiology
Columbia University Medical Center
New York, New York
Brad Perry, MD
Diagnostic Radiology Resident
Department of Radiology
Wake Forest University Health Sciences
Winston-Salem, North Carolina
Andrew T. Trout, MD
Assistant Professor of Radiology and Pediatrics
Director, Nuclear Medicine
Director, Clinical Research (Radiology)
Department of Radiology
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
Paula Vergara-Wentland, MD
Diagnostic Radiology Fellow
Department of Radiology
Wake Forest University Health Sciences
Winston-Salem, North Carolina
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SPECIALTY IMAGING: PET ISBN: 978-0-323-52484-1
Copyright © 2018 by Elsevier. All rights reserved.
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This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be
noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and
experience broaden our understanding, changes in research methods, professional practices,
or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in
evaluating and using any information, methods, compounds, or experiments described
herein. In using such information or methods they should be mindful of their own safety
and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check
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take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or
editors, assume any liability for any injury and/or damage to persons or property as a matter
of products liability, negligence or otherwise, or from any use or operation of any methods,
products, instructions, or ideas contained in the material herein.
Publisher Cataloging-in-Publication Data
Names: Bennett, Paige.
Title: Specialty Imaging. PET / [edited by] Paige Bennett.
Other titles: PET.
Description: First edition. | Salt Lake City, UT : Elsevier, Inc., [2017] | Includes
bibliographical references and index.
Identifiers: ISBN 978-0-323-52484-1
Subjects: LCSH: Tomography--Handbooks, manuals, etc. | Radiography--Handbooks, manuals, etc. |
MESH: Radiography--methods--Atlases. | Radiography, Dual-Energy Scanned Projection--methods--Atlases. |
Tomography, Emission-Computed, Single-Photon--methods--Atlases. | Tomography, X-Ray
Computed--methods--Atlases.
Classification: LCC RC78.S63 2017 | NLM WN 200 | DDC 616.0757’2--dc23
International Standard Book Number: 978-0-323-52484-1
Cover Designer: Tom M. Olson, BA
Printed in Canada by Friesens, Altona, Manitoba, Canada
Last digit is the print number: 9 8 7 6 5 4 3 2 1
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DEDICATION
For Dad, Mom, Betsy, Sidney, and Lee Andrew.
Thankful for this time with you all.
PB
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CONTRIBUTING AUTHORS
Ashley F. Blurton, MD, MS Jacob Blackwell, MD
Assistant Professor Wake Forest School of Medicine
Nuclear Medicine Winston-Salem, North Carolina
Department of Radiology and Medical Imaging
University of Virginia School of Medicine Adam G. Johnson, MD
Charlottesville, Virginia Wake Forest School of Medicine
Winston-Salem, North Carolina
Angela P. Bruner, PhD, DABR
Director, Radiation Safety Officer, Medical Physicist Robert M. Morgan, Jr., MD
Radiation Safety & Medical Physics Wake Forest School of Medicine
Baylor Scott & White Health Winston-Salem, North Carolina
Dallas, Texas
Eric L. Yuan, MD
Erica Cohen, MD
Wake Forest School of Medicine
Assistant Chief of Nuclear Medicine Winston-Salem, North Carolina
Edward Hines VA Medical Center
Hines, Illinois
Assistant Professor of Radiology
Loyola University Medical Center
Maywood, Illinois
Additional Contributors
Erin Grady, MD, CCD, FACNM
Nuclear Medicine Physician
John Bailey, MD
Christiana Care Health System
Newark, Delaware Aidan Burke, MD
Abdul-Rahman Abualuz, MD Hollins Clark, MD
Department of Radiology
James Patrick Davidson, MD
Wake Forest Health Sciences
Winston-Salem, North Carolina Pushpender Gupta, MBBS
Kelli Y. Ha, MD
Brian L. Bones, MD
Department of Radiology John M. Holbert, MD, FACR
Wake Forest Health Sciences
Winston-Salem, North Carolina Katarina Kesty, MD, MBA
Amanda Jo Lott Marcellino, MD
Todd Michael Danziger, MD
Department of Radiology Ashley C. Mays, MD
Wake Forest Health Sciences
Bryan J. Neth, BS
Winston-Salem, North Carolina
Umesh D. Oza, MD
Nathaniel Garrett Gray, MD
Department of Radiology Virginia Barnes Planz, MD
Wake Forest Health Sciences
Anita Thomas, MD
Winston-Salem, North Carolina
Pavani Thotakura, MD
Jennifer Schroeder, MD
Bimal Vyas, MD, MS
Department of Radiology
Wake Forest Health Sciences
Christopher T. Whitlow, MD, PhD, MHA
Winston-Salem, North Carolina
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PREFACE
PET has revolutionized the fields of oncology, cardiology, and neurology. The overwhelming success of
F-18 FDG in clinical use has demonstrated the true power of molecular imaging and has led to additiona l
regulatory approvals of molecular PET agents for clinical practice, including new tracers that target amyloid
in Alzheimer disease, radiolabeled peptides that target somatostatin receptors on tumors, and radiolabeled
amino acids to image prostate cancer.
These developments have led to a renaissance in nuclear medicine that has changed the way patients
are managed and treated. The highly sensitive F-18 FDG PET is now being augmented by PET tracers
with increased specificity. PET offers physicians an early opportunity to alter therapeutics if they are not
efficacious after a trial period and before adverse effects are evident. As PET research continues, it will
continue to assist in personalized medicine by enabling highly specific therapies, giving patients the best
chance at successful treatment.
Clinicians including nuclear medicine radiologists, radiation oncologists, oncologists, oncology surgeons,
trainees in nuclear medicine and oncology plus researchers in drug development and molecular imaging
need to keep up with existing and emerging PET technologies currently in clinical practice. Specialty Imaging:
PET, first edition is a reference text covering:
• Interpretation, artifacts, and common pitfalls
• Oncologic PET diagnoses with staging tables and reporting tips
• CNS PET indications, including dementia, epilepsy, oncology
• Cardiac PET indications including stress tests, cardiac viability, sarcoidosis
• Infection and inflammation PET
• PET physics and instrumentation
• Clinical and research PET radiotracers and their indications
The authoring team that developed this text is a group of dedicated nuclear medicine physicians and
radiologists involved in both clinical practice and academic pursuits. Lead authors including myself, Dr.
Paige Bennett, and Dr. Andrew Trout have worked to deliver expertise and case examples in the fields of
neuroimaging, oncology, and pediatrics. In addition, over 30 contributing authors–led by Drs. Brad Perry
and Paula Vergara-Wentland–have generously shared their expertise and case examples inside this book to
bring the reader up-to-date on clinical PET imaging.
Akiva Mintz, MD, PhD, MHA, CFA
Professor and Vice Chair of Translational Research, Radiology
Director, PET Center
Division Chief, Nuclear Medicine and Molecular Imaging
Department of Radiology
Columbia University Medical Center
New York, New York
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