Table Of ContentADVANCES IN
Metabolic Disorders
Edited by
Rachmiel Levine Rolf Luft
City of Hope Medical Center Department of Endocrinology
Duarte, California and Metabolism
Karolinska Hospital
Stockholm, Sweden
Supplementary Volumes
1. Early Diabetes
Edited by Rafael A. Camerini-Davalos and Harold S. Cole
2. Vascular and Neurological Changes in Early Diabetes
Edited by Rafael A. Camerini-Davalos and Harold S. Cole
ADVANCES IN
Metabolic Disorders
VOLUME 8
SOMATOMEDINS
and Some Other Growth Factors
Proceedings of the Twenty-Eighth Nobel Symposium
held at Hässelby, Sweden,
September 4-7, 1974
Edited by
Rolf Luft Kerstin Hall
Deportment of Endocrinology Department of Endocrinology
and Metabolism and Metabolism
Karolinska Hospital Karolinska Hospital
Stockholm, Sweden Stockholm, Sweden
Administrative Editor
Vera Runnström-Reio
1975
@
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Contributors
Numbers in parentheses indicate the pages on which the authors' contributions begin.
J. B. BASEMAN Department of Bacteriology, University of North Carolina, School
of Medicine, Chapel Hill, North Carolina (127)
K. BENIRSCHKE Department of Obstetrics and Gynecology, University of California,
San Diego, California (301)
RALPH A. BRADSHAW Department of Biological Chemistry, Division of Biology
and Biomedical Sciences, Washington University, St. Louis, Missouri (285)
GRAHAM CARPENTER Department of Biochemistry, Vanderbilt University, School
of Medicine, Nashville, Tennessee (265)
D. R. CLEMMONS Department of Pediatrics, University of North Carolina, School
of Medicine, Chapel Hill, North Carolina (127)
STANLEY COHEN Department of Biochemistry, Vanderbilt University, School of
Medicine, Nashville, Tennessee (265)
WILLIAM H. DAUGHADAY Metabolism Division, Department of Medicine, Washing-
ton University School of Medicine, St. Louis, Missouri (151, 159)
E. EIGENMANN Metabolic Unit, Department of Medicine, University of Zurich,
Zurich, Switzerhnd (237)
WERNER FRANK Max-Planck-Institut für Virusforschung, Abteilung für Physika-
lische Biologie, Tübingen, West Germany (337)
WILLIAM A. FRAZIER Department of Psychiatry, University of California, San
Diego, School of Medicine, La Jolla, California (285)
E. R. FROESCH Metabolic Unit, Department of Medicine, University of Zürich,
Kantonsspital, Zürich, Switzerland (203, 211, 237)
LINDA FRYKLUND AB KABI, The Recip Polypeptide Laboratory, Stockholm,
Sweden (19, 47, 61)
xv
xvi Contributors
LYNN P. GIMPEL Department of Physiology, Emory University, Atlanta, Georgia
(H9)
ALLAN L. GOLDSTEIN Division of Biochemistry, Department of Human Biological
Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas
(359)
DENIS GOSPODAROWICZ The Salk Institute for Biological Studies, San Diego, Cali-
fornia (301)
JOHANNA GRIMM Max-Planck-Institut für Virusforschung, Abteilung für Physika-
lische Biologie, Tübingen, West Germany (337)
KERSTIN HALL Department of Endocrinology and Metabolism, Karolinska Hos-
pital, Stockholm, Sweden (19, 47, 61, 73)
R. HEIMANN Departments of Medicine and Biochemistry, University of Zürich,
Zürich, Switzerland (203, 237)
U. HEINRICH Department of Pediatrics, Erasmus University, Rotterdam, The
Netherlands (171)
A. C. HERINGTON* Metabolism Division, Department of Medicine, Washington
University School of Medicine, St. Louis, Missouri (151)
R. L. HINTZ Department of Pediatrics, University of Connecticut, School of Medi-
cine, Farmington, Connecticut (127)
RAINER HOFFMAN Max-Planck-Institut für Virusforschung, Abteilung für Physika-
lische Biologie, Tübingen, West Germany (337)
RUTH A. HOGUE-ANGELETTI The Institute for Cancer Research, Philadelphia, Penn-
sylvania (285)
R. E. HUMBEL Departmeids of Medicine and Biochemistry, University of Zürich,
Zürich, Switzerland (203)
OLLE ISAKSSON Department of Physiology, University of Göteborg, Göteborg,
Sweden (249)
U. KAUFMANN Metabolic Unit, Department of Medicine, University of Zürich,
Zürich, Switzerland (211)
JACK L. KOSTYO Department of Physiology, Emory University, Atlanta, Georgia
(249)
* Present address: Medical Research Centre, Prince Henry's Hospital, St. Kilda
Road, Melbourne, Australia.
Contributors xvii
KENNETH J. LEMBACH Department of Biochemistry, Vanderbilt University, School
of Medicine, Nashville, Tennessee {265)
JON LINDSTROM The Salk Institute for Biological Studies, San Diego, California
(301)
ROLF LUFT Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
(3, 73, 431)
M. MÄDER Metabolic Unit, Department of Medicine, University of Zürich, Zürich,
Switzerland (211)
R. N. MARSHALL* Department of Pediatrics, University of North Carolina, School
of Medicine, Chapel Hill, North Carolina (127)
C. MEULI Metabolic Unit, Department of Medicine, University of Zürich, Zürich,
Switzerland (211)
Β. MORELL Metabolic Unit, Department of Medicine, University of Zürich, Zürich,
Switzerland (211)
IRA PASTAN Laboratory of Molecular Biology, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland (7, 377)
L. S. PfflLLiPsf Metabolism Division, Department of Medicine, Washington Uni-
versity School of Medicine, St. Louis, Missouri (151)
HANS-JÜRGEN RISTOW Max-Planck-Institut für Virusforschung, Abteilung für Physi-
kalische Biologie, Tübingen, West Germany (337)
W. J. RITSCHARD Diagnostic Research Department, F. Hoffmann-La Roche ά Co.,
Basel, Switzerland (203)
PHILLIP RUDLAND Imperial Cancer Research Fund, London, England (301)
WILLIAM D. SALMON, JR. Veterans Administration Hospital and Department of
Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee (1S3)
U. SCHLUMPF Departments of Medicine and Biochemistry, University of Zürich,
Zürich, Switzerland (203, 237)
* Present address : Department of Pediatrics, University of Texas Medical School,
Houston, Texas.
t Present address: Center for Endocrinology, Metabolism, and Nutrition, North-
western University School of Medicine, Chicago, Illinois.
xviii Contributors
HANS SIEVERTSSON AB KAB1, The Recip Polypeptide Laboratory, Stockholm,
Sweden (19, 47, 61)
KAZUE TAKANO Department oj Endocrinology and Metabolism, Karolinska Hos-
pital, Stockholm, Sweden (19, 61)
L. E. UNDERWOOD Department of Pediatrics, University of North Carolina, School
of Medicine, Chapel Hill, North Carolina (127)
KNUT UTHNE AB KABI, The Recip Polypeptide Laboratory, Stockholm, Sweden
(47, 101, 115)
SYLVIA VAN BUUL Department of Pediatrics, Erasmus University, Rotterdam, The
Netherlands (171)
J. L. VAN DEN BRANDE Department of Pediatrics, Erasmus University, Rotterdam,
The Netherlands (171)
F. VAN ROON The Bergweg Hospital, Rotterdam, The Netherlands (171)
A. C. VAN STEIRTEGEM The Free University of Brussels, Brussels, Belgium and
The Medical Mission of CEMUBAC to IRSAC, Kuvu, Zaire (171)
J. J. VAN WYK Department of Pediatrics, University of North Carolina, School
of Medicine, Chapel Hill, North Carolina (127)
JOSEF VESER Max-Planck-Institut für Virusforschung, Abteiling für Physikalische
Biologie, Tübingen, West Germany (337)
M. WALDVOGEL Metabolie Unit, Department of Medicine, University of Zürich,
Zürich, Switzerland (211)
ÂKE WASTESON Institute of Medical and Physiological Chemistry, Uppsala Univer-
sity, Uppsala, Sweden (85, 101)
BENGT WESTERMARK The Wallenberg Laboratory, Uppsala University, Uppsala,
Sweden (47, 85, 101)
ABRAHAM WHITE Syntex Research, Palo Alto, California and Department of Bio-
chemistry, Stanford University School of Medicine, Stanford, California (359)
ROSALYN S. YALOW Solomon A. Berson Research Laboratory, Veterans Administra-
tion Hospital, Bronx, New York, and Department of Medicine, Mt. Sinai School
of Medicine, The City University of New York, New York (73)
J. ZAPF Departments of Medicine and Biochemistry, University of Zürich, Zürich,
Switzerland (203, 211, 237)
T. ZÜRCHER Department of Pediatrics, Erasmus University, Rotterdam, The Neth-
erlands (171)
Contents of Previous Volumes
Volume 1
GLYCOGEN STORAGE DISEASE
H. G. Hers
THE PARATHYROIDS
G. D. Arnbach and John T. Potts, Jr.
MITOCHONDRIAL RESPIRATORY CONTROLS: BIOCHEMICAL, PHYSIOLOGICAL,
AND PATHOLOGICAL ASPECTS
Lars Ernster and Rolf Luft
OSTEOPOROSIS
B. E. C. Nordin
BASAL METABOLIC RATE AND THYROID HORMONES
J. R. Tata
INSULIN ANTAGONISTS AND INHIBITORS
J. Vallance-Owen
ALDOSTERONE: ITS BIOCHEMISTRY AND PHYSIOLOGY
John H. Laragh and William G. Kelley
FOLIC ACID DEFICIENCY IN MAN AND ITS INTERRELATIONSHIP WITH
VITAMIN B METABOLISM
12
A. Leonard Luhby and Jack M. Cooperman
AUTHOR INDEX—SUBJECT INDEX
Volume 2
GOUT
James B. Wyngaarden
NITROGEN-RETAINING STEROIDS AND THEIR APPLICATION IN DISEASE
A. Querido and A. A. H. Kassenaar
MACROGLOBULINEMIA
Jan Waldenstrom
xix
XX Contents of Previous Volumes
TESTING THE FUNCTIONAL CAPACITY OF THE TRYPTOPHAN-NIACIN
PATHWAY IN MAN BY ANALYSIS OF URINARY METABOLITES
J. M. Price, R. R. Brown, and Norma Y ess
THE SYNDROME OF TESTICULAR FEMINIZATION
A. Louis Southren
AUTHOR INDEX—SUBJECT INDEX
Volume 3
KETOGENESIS AND ITS REGULATION
0. Wieland
SPONTANEOUS DIABETES AND/OR OBESITY IN LABORATORY RODENTS
Albert E. Renold
ETHANOL-INDUCED HYPOGLYCEMIA
Leonard L. Madison
HORMONAL SYNDROMES ASSOCIATED WITH NEOPLASIA
Mortimer B. Lipsett
METABOLIC DISORDERS OF THE OVARY
Bruno Lunenfeld, Aliza Eshkol, Vaclav Insler, and Zaki Kraiem
THE NATURE AND SIGNIFICANCE OF THE LONG-ACTING THYROID
STIMULATOR
Joseph P. Kriss
THYROID AUTOANTIBODIES IN THYROID DISEASES
Noel R. Rose and Ernest Witebsky
ERYTHROPOIETIN
Clifford W. Gurney
AUTHOR INDEX—SUBJECT INDEX
Volume 4
INTESTINAL FACTORS IN THE REGULATION OF INSULIN SECRETION
Vincent Marks and Ellis Samols
ANTIDIURETIC HORMONE SYNTHESIS, RELEASE, AND ACTION UNDER
NORMAL AND PATHOLOGICAL CIRCUMSTANCES
Niels A. Thorn
Contents of Previous Volumes xxi
DlSACCHARIDASE DEFICIENCY
David H. Alpers and Kurt J. Isselbacher
HORMONAL CONTROL OF FETAL DEVELOPMENT AND METABOLISM
Alfred Jost and Luc Picon
THE METABOLISM OF THE PLACENTA
Andrew J. Szabo and Richard D. Grimaldi
METABOLIC ASPECTS OF OBESITY
E. S. Gordon
THE USE OF LIQUID FORMULA DIETS IN METABOLIC STUDIES: 15 YEARS'
EXPERIENCE
Ε. H. Ahrens, Jr.
AUTHOR INDEX—SUBJECT INDEX
Volume 5
HYPOTHALAMIC CONTROL OF THE SECRETION OF ADENOHYPOPHYSIAL
HORMONES
Roger G utile min
ADRENOCORTICAL CONTROL OF EPINEPHRINE SYNTHESIS IN HEALTH AND
DISEASE
R. J. Wurtman and L. A. Pohorecky
THE RELATIONSHIP BETWEEN ANGIOTENSIN AND ALDOSTERONE
G. W. Boyd and W. S. Peart
THE METABOLIC INFLUENCE OF PROGESTINS
Richard L. Landau and James T. Poulos
THE THYMUS GLAND: EXPERIMENTAL AND CLINICAL STUDIES OF ITS ROLE
IN THE DEVELOPMENT AND EXPRESSION OF IMMUNE FUNCTION
Allan L. Goldstein and Abraham White
CONTROL OF GLUCOSE METABOLISM IN THE HUMAN FETUS AND
NEWBORN INFANT
Peter A. J. Adam
HUMAN ADIPOSE TISSUE DYNAMICS AND REGULATION
Per Björntorp and Jan Östman
CORONARY DISEASE AND CARBOHYDRATE AND FAT ABNORMALITIES
Michael V. Herman and Richard Gorlin
AUTHOR INDEX—SUBJECT INDEX
