Small Wonders: Peptides for Disease Control

465 Pages·2012·17.22 MB·English

by  Kanniah Rajasekaran

Small Wonders: Peptides for
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In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
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In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
1095
ACS SYMPOSIUM SERIES
Small Wonders: Peptides for
Disease Control
Kanniah Rajasekaran, Editor
Southern Regional Research Center
1
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bs.acs.or2-1095.f New Orleans, Louisiana
pu01 Jeffrey W. Cary, Editor
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28, 20oi: 10. New Orleans, Louisiana
May 2 | d Jesse M. Jaynes, Editor
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35.42 pril 4, Tuskegee University, Tuskegee, Alabama
89.163.Web): A UEnmiveirlsiiotyMofoGnirtoensai,nGoirso,nEa,dSiptoairn
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wnloaation Sponsored by the
Doublic ACSDivisionofAgriculturalandFoodChemistry,Inc.
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AmericanChemicalSociety,Washington,DC
DistributedinprintbyOxfordUniversityPress,Inc.
In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
LibraryofCongressCataloging-in-PublicationData
Smallwonders:peptidesfordiseasecontrol/KanniahRajasekaran...[etal.],editor[s].
p.;cm.-- (ACSsymposiumseries;1095)
1 "SponsoredbytheACSDivisionofAgriculturalandFoodChemistry,Inc."
0
0 Includesbibliographicalreferencesandindex.
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In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
Foreword
The ACS Symposium Series was first published in 1974 to provide a
mechanism for publishing symposia quickly in book form. The purpose of
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sponsoredsymposiabasedoncurrentscientificresearch. Occasionally,booksare
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In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
Preface
The human tendency to regard little things as important has produced very
manygreatthings.
-GeorgC.Lichtenberg
1
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http://pubs.ac1/bk-2012-10 htophifrgeevhtdhe-trnehiitvrraoitniuavggnehtfipommurecticdesrioccbirbeneiheeainslnidnaasgctthwiaveseistldialeeyasvsse,ltiootnhpimtsnhoeecvnlecatlososnfmtornoefelthxaoont-fdtgispmelnaifecnorrtraotbditoiihasneeliartashgeesesry.nantpstMehuheotasiriscessbtahaenneandnd
012 | 0.102 1700 natural AMPs from a wide range of life forms ranging from prokaryotes
21 to humans have been characterized to date and many of these have served as
May 28, 2 | doi: tsepmecpilfiacteitsy,fosrtatbhielitrya,tiaonndalbdioesaivganilaobfilsiytyn.theOtinccepetphtoiduegshtwtiothbiemvperoryveudnipfootremnciyn,
1
2 on 4, 20 their antimicrobial activity as membrane disruptants, research is now revealing
3.35.4April hthoestm’suilntinfautnecitmiomnaulnnitaytubruetoaflstoheassemmoodlueclautloerssaosfcthrieticaadlapptliavyeerismnmoutnoenrlyesipnonthsee
9.16eb): in mammals or as elicitors of defense responses in plants. Several AMPs not
wnloaded by 8ation Date (W omaimnenlpmyoonbrfdtruaeannsntctertbsuioicobntluiovtsgeoaicllmesalolaynfhuntanhevcrreotiauotnghndhesiaaninbntdeitlerilarteaycactdttiowioningcthrtoaosinnscdtertalhdlceidesrlepluaaupttlhhtai.orognteanrog’fsetcpseailtnlhtomegrefeemnribncrgealnlweuiltiahnr
Doblic AMPtechnologyhastremendousimplicationsforthedevelopmentofnovel
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P therapeuticsandplantprotectivestrategies. Thisbookassemblescontributionsby

internationally acclaimed scientists with a focus on therapeutic and agricultural
applications. Promising medical applications of peptide technology include
treatmentsforbacterial,fungalandviralinfections. Productionofmoreeffective
peptides,targetingthetreatmentofcancer,utilizesnovelstrategiesfordesigning
peptide immunogens to elicit specific antibodies. In humans, peptides that
modulate the host’s adaptive immune response will not be recognized by
the invading pathogen as a defense factor and therefore will not be prone to
development of resistance by the pathogen. Agricultural applications include
control of devastating plant diseases caused by microbial pathogens, some of
them resulting in mycotoxin contamination of food and feed products. Though
plants and their various pathogens wage a continuous war of resistance against
one another, transgenic strategies that utilize AMPs with different modes of
action (both extra- and intracelluarly) against target pathogens should provide a
ix
In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
selfdefensemechanismthatwillbemuchharderforthepathogentocircumvent
anddevelopresistance.
This book is the result of the symposium “Small Wonders: Peptides for
Disease Control” held at the 240th National Meeting of the American Chemical
Society in Boston, MA, August 22-26, 2010. To our knowledge, this is the first
bookthatcoversabroadrangeofpeptidetechnologyanditspracticalapplication
intheagricultural,medical,andpharmaceuticalfields. Theup-to-datereviewsand
original research presented in this book will be of interest to a diverse audience
including scientists in the medical, pharmaceutical, agricultural, chemical and
biotechnological fields. Biochemists, molecular biologists, microbiologists and
graduatestudentsengagedinresearchandthedevelopmentofpeptideswillfind
this book a useful reference tool. In summary, this book will represent a timely
and much-needed comprehensive update of the literature in the field of peptides
01 fordiseasecontrol,animportantandfast-movingsubjectarea.
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May 2 | d ArleneFurman,andMaryCalvertandforthecoverdesignbyPamelaKame.
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35.4pril KanniahRajasekaran
89.163.Web): A RFoeosedaarcnhdBFeioeldogSiasftetyResearchUnit
ded by Date ( SUoSuDthAerAngRriecguilotnuarallRReesseeaarcrchhCSeenrtveirce
wnloaation 1100RobertE.LeeBlvd.
Doblic NewOrleans,LA70124,U.S.A.
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[phone](fax)
[email protected](e-mail)
JeffreyW.Cary
MolecularBiologist
FoodandFeedSafetyResearchUnit
SouthernRegionalResearchCenter
USDAAgriculturalResearchService
1100RobertE.LeeBlvd.
NewOrleans,LA70124,U.S.A.
[phone](telephone).
[email protected](e-mail)
x
In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
JesseM.Jaynes
ProfessorofBiochemistry
TuskegeeUniversity
Tuskegee,AL36088,U.S.A.
[phone](telephone)
[email protected](e-mail)
EmilioMontesinos
ProfessorofCropScience(PlantPathology)
InstituteofFoodandAgriculturalTechnology
UniversityofGirona
CampusMontilivi,s/n
01 17071Girona,Spain
s.org 95.pr0 e+m34ili9o7.m24o1n8te4s2in7o([email protected]) (e-mail)
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xi
In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.
Editors’ Biographies
Kanniah Rajasekaran
KanniahRajasekaranisaResearchBiologistwiththeFoodandFeedSafety
Research Unit, Agricultural Research Service, USDA in New Orleans, LA.
He is an international authority on application of aseptic cell/tissue culture and
recombinant DNA technologies towards genetic improvement of food and feed
crops. HereceivedhisB.S.andM.S.inAgriculturalSciencesfromTamilNadu
g 01
s.acs.or095.ot0 AthgerUicnuilvtuerraslitUynoivfeSrysidtyn,eCy,oAimubstartaolriea,.InHdeiamaonvdePdht.Do.hiinsCcurorrpeBntioptoescihtinoonlowgyithfrothme
b1 USDA, ARS in 1996 after a considerable industry experience with Phytogen, a
pu2-
p://201 plantbiotechnologycompanyinPasadena,California. Currentresearchinterests
2 | htt1/bk- oinfclturadneshgoesnti-cpacthoottgoenn/croerlant/ipoenasnhuipt,vaanrtiiefutinegsalwpirtohterienssisatnadncpeepttoidepsh,ydteovpealtohpomgeennst
12
00
21 includingmycotoxin-producingfungi,andtissue-ororganelle-specificexpression
V on May 29, 2012 | doi: 10. of transgenes. Jeffrey W. Cary
NI4,
L Upril JeffreyW.CaryisaMolecularBiologistintheFoodandFeedSafetyResearch
RNELeb): A UthneietliuncNideawtioOnrolefathnes,gwenheicshinhvaoslvreecdeiinveadflaintotexrinnabtiioonsaylnrtheceosigsnaintidonthfeoirrritesgwuloartikoinn.
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ded by Con Date ( aHCnledosestaurribndseieudqmuheainsctelPythop.bDeur.tfyoilnricmMuemdicaprocoebsttiodonoloecg/tboyuratfarlonremoslefLaerorcmuhiesoinnatnatathieoSnmtaaotteleRUciucnleiavrUebrnisioivtlyeorgsiynitoy1.f9tH8h6ee
DownloaPublicati 1jo9i8n9edwthheereUhSeDhAa,sAbeReSn,sStuoduythinegrnthReergeigounlaaltiRonesoefarfcuhngCaelndteevrealtopNmewentOarnledatnosxiinn
production as well as engineering plants for expression of novel antimicrobial
peptides/proteinsasameanstocontrolaflatoxincontaminationinfoodandfeed
crops. Dr. Caryhasappearedasanauthorin110publicationsandservedasChair
of (2003−04) of the Fermentation and Biotechnology Division of the American
SocietyforMicrobiology.
Jesse M. Jaynes
JesseM.JaynesisaProfessorofBiochemistryatTuskegeeUniversitywhere
hedoesresearchandteachesbiochemistryintheIntegrativeBiosciencesProgram.
He received his associate degree in anthropology from College of Eastern Utah,
B.S.degreeinbiologyfromSouthernUtahStateCollegeandPh.D.inchemistry
fromBrighamYoungUniversitymentoredbyLeoVernon. HereceivedanNSF
©2012AmericanChemicalSociety
In Small Wonders: Peptides for Disease Control; Rajasekaran, K., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2012.