Table Of ContentSleep Neurology
A Comprehensive Guide
to Basic and Clinical Aspects
Lourdes M. DelRosso
Raffaele Ferri
Editors
123
Sleep Neurology
Lourdes M. DelRosso • Raffaele Ferri
Editors
Sleep Neurology
A Comprehensive Guide to Basic
and Clinical Aspects
Editors
Lourdes M. DelRosso Raffaele Ferri
Sleep Disorders Center Sleep Research Centre
UCSF Benioff Children’s Hospital Oasi Maria SS
San Francisco TROINA
CA Enna
USA Italy
ISBN 978-3-030-54358-7 ISBN 978-3-030-54359-4 (eBook)
https://doi.org/10.1007/978-3-030-54359-4
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Foreword
Long ago, when I started learning about Sleep Medicine, the only clinical text avail-
able was Christian Guilleminault’s landmark book Sleeping and Waking Disorders:
Indications and Techniques. Wow, has that limited publication availability ever
changed over the ensuing years! Currently there so many more books it is some-
times overwhelming for someone seeking good texts. Available formats include
encyclopedic approaches, broad coverage–limited depth approaches, update books,
small scope–high depth of subject, and board review–focused publications, just to
name a few. Now, when I see a new book I ask, “Is this one useful?” and “For what
audiences?” As a career educator, I also look for applicability for both learners and
teachers as well. I believe the answer for Sleep Neurology: A Comprehensive Guide
to Basic and Clinical Aspects, edited by Lourdes M. DelRosso and Raffaele Ferri,
is a clear yes; it is useful to the sleep medicine field.
Those looking for a solid coverage with updated information about relevant clin-
ical aspects of the field of Sleep Medicine as related to Neurology, but less material
than wading through an encyclopedia, will find a good clinical focus and solid cov-
erage of major underlying facts and findings. As an added bonus, many of the
authors are experienced faculty, having focused their career on teaching, both at
their academic institutions as well as for the American Academy of Sleep Medicine
committees, courses, and publications. That combination results in a recipe for suc-
cess with their subject coverage.
Cross discipline students, residents and fellows, sleep fellows, mid-level practi-
tioners from neurology-based programs, neurologists, and sleep medicine practitio-
ners who want to learn more about sleep and neurology interrelation, and those
looking for solid coverage of the indexed subjects, especially relevant for teaching,
are all likely beneficiaries.
The book’s overall organizational format is well designed to be helpful to the
reader. The chapters typically provide an efficient focus for the presented topic with
an abstract, keywords, and/or an introduction to indicate the scope. The chapter
organization includes integrating the neurological topic with the relevant sleep med-
icine topic(s) making it useful whether the reader is looking for specific areas of
sleep or neurology focus, or for providing a framework for the integration of the
fuller topic scope of that chapter. References are provided liberally for readers
wanting greater depth in specific areas but who do not wish to get bogged down in
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vi Foreword
excessive detail while reading. The coverage of neurology topics related to sleep
appears to have been well thought out.
I believe the reader will likely find their time well spent as they read this book
and that it will be a useful addition to the educational literature on Neurology and
Sleep Medicine.
Andrew L. Chesson Jr, MD
Dean Emeritus, School of Medicine
Professor Emeritus Neurology and Division of Sleep Medicine
LSU Health Sciences Center – Shreveport
Shreveport, LA, USA
Preface
Sleep science has undergone incredible development during the last decades, prob-
ably more pronounced than other areas of science. This rapidly evolving field is still
demonstrating a fast growth which will probably continue in future years. As a
result of this astonishing increase in knowledge and pieces of information coming
from a wide range of studies, experts dealing with sleep disorders may find it diffi-
cult to integrate this amount of information in their clinical practice.
It is with great hope we present Sleep Neurology: A Comprehensive Guide to
Basic and Clinical Aspects as a useful aid to sleep clinicians, researchers, and the
neurology and medical community in general. With this book, we want to present
easy access to a comprehensive view of the neurologic basis of sleep disorders. We
have gathered together experts from all over the world to contribute to this book,
with a goal to connect the neurophysiology of sleep with sleep disorders seen in
common neurologic conditions. We want the information to be relevant to the
understanding of sleep processes, practical to highlight important clinical informa-
tion, and concise to summarize all the key facts in sleep and neurology. The review
of the list of pertinent citations and references at the end of each chapter provides
the opportunity to expand the knowledge beyond the current volume. The group of
authors are experts in their field and represent colleagues from various regions of
the world, including Europe and North and South America. The contributors bring
various perspectives and expertise to this volume.
In this first edition, we organize the material into two main parts. The first part
covers the neurobiology of normal sleep and sleep functions. We start with a general
description of sleep and wakefulness, discussing the circadian and homeostatic con-
trol of sleep, expanding into the neurophysiology of dreams, memory consolidation,
and sleep deprivation. The second part is dedicated to the understanding of sleep
symptomatology in various neurologic conditions. Here, we discuss sleep changes
in patients with dementia, seizures, headaches, and stroke among other common
neurologic disorders. Illustrations and tables are added to emphasize important key
points discussed in each chapter.
As said above, the knowledge about the science of sleep has grown exponentially
in the last decade and research has shown the association between sleep disorders
and many other medical conditions. Sleep disorders can contribute to comorbidities
and, vice versa, medical/neurological conditions can present with specific sleep dis-
orders. As knowledge of the importance of sleep grows, we see it imperative to
vii
viii Preface
bring forth this book as a reference source of useful information for both clinicians
and researchers.
We want to thank all the authors for their expert knowledge and valuable contri-
bution to this book. We also want to thank Mariah Gumpert and Gregory Sutorius of
Springer for their administrative assistance.
San Francisco, CA, USA Lourdes M. DelRosso
Troina, Enna, Italy Raffaele Ferri
Contents
Part I N eurobiology of Sleep and Wakefulness
1 Neurobiology of Wakefulness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Lourdes M. DelRosso and Marisa Pedemonte
2 Neurobiology of Sleep . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Ibrahim J. Raphael and Marisa Pedemonte
3 Neurobiology of the Control of Sleep . . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Lourdes M. DelRosso, Joanna E. Wrede, Carey T. Lockhart,
and Daniel P. Cardinali
4 The Neurological Consequences of Sleep Deprivation . . . . . . . . . . . . . 45
Lynn Keenan and Karl Van Gundy
5 Neurobiology of Dreams . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Carlo Cipolli and Luigi De Gennaro
6 Neurobiology of Memory and Sleep . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Michael Blechner
7 Neurobiology of Insomnia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Célyne H. Bastien, Thierry Provencher, Jessica Lebel,
and Roxanne Bolduc-Landry
8 Narcolepsy and Central Nervous System Hypersomnias . . . . . . . . . . . 111
Fabio Pizza and Giuseppe Plazzi
9 Neurobiology of Parasomnias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121
Tommaso Baldini, Giuseppe Loddo, Raffaele Ferri, and
Federica Provini
10 Neurobiology of Sleep-Related Movements . . . . . . . . . . . . . . . . . . . . . . 147
Michela Figorilli, Monica Puligheddu, Patrizia Congiu, Stefan
Clemens, and Raffaele Ferri
ix
x Contents
Part II S leep in Neurologic Conditions
11 Sleep in Seizure Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Silvia Miano
12 Sleep in Headaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Oliviero Bruni
13 Sleep in Cerebral Palsy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
Michelle Sobremonte-King
14 Sleep and Cerebrovascular Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Claude Nguyen
15 Sleep in Amyotrophic Lateral Sclerosis . . . . . . . . . . . . . . . . . . . . . . . . . 243
Swapan Dholakia and Saiprakash B. Venkateshiah
16 Sleep After Traumatic Brain Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
Patrizia Congiu, Monica Puligheddu, Michela Figorilli, Stefania
Mondello, and Raffaele Ferri
17 Disorders of Sleep and Wakefulness in Parkinson’s Disease and Other
Movement Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
John C. Carter and Vishesh K. Kapur
18 Sleep in Elderly Adults and in Subjects with Dementia . . . . . . . . . . . . 289
Helmut Frohnhofen and Dirk M. Hermann
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
