Sleep deprivation, stimulant medications, and cognition

296 Pages·2012·8.564 MB·English

by  Wesensten, Nancy J

Sleep Deprivation, Stimulant
Medications, and Cognition

Sleep Deprivation, Stimulant
Medications, and Cognition
Edited by
Nancy J. Wesensten, Ph.D.
CenterforMilitaryPsychiatryandNeuroscience,DepartmentofBehavioralBiology,
WalterReedArmyInstituteofResearch,SilverSpring,MD,USA
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Contents
Listofcontributors pagevii
Foreword:Sustainingcognitiveperformance:amodernimperative ix
DavidDinges
Preface xi
Section 1: Basic Mechanisms:
7 Caffeine:mechanismofaction,genetics,and
Cognitive Performance and behavioralstudiesconductedintask
simulatorsandthefield 93
Sleep
ChristinaE.Carvey,LaurenA.Thompson,
CarolineR.Mahoney,andHarrisR.Lieberman
1 Thetruenatureofsleeploss-induced
“neurocognitiveperformancedeficits”: 8 Stimulantsinmodelsofshiftworkandshift
acriticalappraisal 1 workdisorder 108
ThomasJ.Balkin JonathanR.L.Schwartzand
AaronM.Henley
2 UsingfMRItostudycognitive
functionanditsmodulationin 9 Thepotentialforabuseofstimulants
sleep-deprivedpersons:aselective inchronicallysleep-restricted
overview 7 populations 122
MichaelW.L.CheeandSuMeiLee EmmaChildsandHarrietdeWit
3 Neurochemistryofwakefulness 10 Cognitiveenhancersversus
andsleep 23 stimulants 136
RobertE.Streckerand MeganSt.PetersandMartinSarter
JamesT.McKenna
11 NovelpathwaysforstimulantdevelopmentI:
4 Genetic basis of individual vulnerability targetingthehistaminergicsystem 152
to sleep loss and responsivity to JohnJ.Renger
stimulants 43
12 Novelpathwaysforstimulant
PhillipJ.Quartanaand
developmentII:thehypocretin/orexin
TracyL.Rupp
system 165
RaviK.PasumarthiandThomasS.Kilduff
Section 2: Stimulant Reversal of
Cognitive Deficits Section 3: Alternatives for Sustaining
Cognitive Performance During
5 Modafinilreversalofcognitive
deficitsduringsleeploss 58 Sleep Loss
NancyJ.Wesensten
13 Lightexposureforimprovingcognition
6 Utilityofcaffeine:evidencefrom duringsleeplossandcircadian
thelaboratory 82 misalignment 184
MichaelH.Bonnetand KennethP.Wright,Jr.,TinaM.Burke,
DonnaL.Arand andMarkR.Smith
v
Contents
14 Nutritionalcountermeasuresforcognitive Section 4: Summary and Conclusions
performancedecrementsfollowingsleep
17 Useofstimulantsinoperationalsettings:
deprivation 199
issuesandconsiderations 237
CarolineR.MahoneyandHarrisR.Lieberman
NicholasDavenport,CherylLowry,andBrian
15 Theroleofalertnessmonitoring
Pinkston
insustainingcognitionduring
18 Fatiguemanagement:theartofthestate 257
sleeploss 209
TracyL.Rupp,NancyJ.Wesensten,and
MelissaM.MallisandFrancineO.James
ThomasJ.Balkin
16 Sustainingneurobehavioralperformanceon
lesssleep:isSWSenhancementthekey? 223
JanineM.Hall-Porterand
JamesK.Walsh
Index 268
vi
Contributors
DonnaL.Arand,Ph.D. AaronM.Henley,B.A.,R.P.S.G.T.
ClinicalDirectoroftheKetteringMedicalCenter INTEGRISSleepDisordersCenterandUniversityof
SleepDisordersCenter,WallaceKettering OklahomaHealthSciencesCenter,Departmentof
NeuroscienceInstitute,Kettering,OH,USA Medicine,OklahomaCity,OK,USA
ThomasJ.Balkin,Ph.D. FrancineO.James,Ph.D.
Chief,BehavioralBiologyBranch, InstitutesforBehaviorResources,Inc.,Baltimore,
CenterforMilitaryPsychiatryandNeuroscience, MD,USA
WalterReedArmyInstituteofResearch,
ThomasS.Kilduff,Ph.D.
SilverSpring,MD,USA
CenterforNeuroscience,BiosciencesDivision,SRI
MichaelH.Bonnet,Ph.D. International,MenloPark,CA,USA
ProfessorofNeurology,WrightStateUniversity
SuMeiLee,B.S.
SchoolofMedicineandDirectoroftheSleepCenter
CognitiveNeuroscienceLab,Neuroscienceand
attheDepartmentofVeteransAffairsMedicalCenter,
BehavioralDisordersProgram,Duke-NUSGraduate
Dayton,OH,USA
MedicalSchool,Singapore
TinaM.Burke,M.S.,Ph.D.
HarrisR.Lieberman,Ph.D.
DepartmentofIntegrativePhysiology,
UnitedStatesArmyResearchInstituteof
SleepandChronobiologyLaboratory,Universityof
EnvironmentalMedicine,Natick,MA,USA
ColoradoatBoulder,CO,USA
CherylLowry,M.D.,M.P.H.
ChristinaE.Carvey,M.S.
MPH,UnitedStatesAirForceMedicalSupport
ResearchDietitian,MilitaryNutritionDivision,
Agency,Arlington,VA,USA
USArmyResearchInstituteofEnvironmental
Medicine,Natick,MA,USA CarolineR.Mahoney,Ph.D.
NatickSoldierResearchDevelopmentand
MichaelW.L.Chee,M.B.B.S.
EngineeringCenter,CognitiveSciences,KansasStreet,
CognitiveNeuroscienceLab,Neuroscienceand Natick,MA,USA
BehavioralDisordersProgram,Duke-NUSGraduate
MedicalSchool,Singapore MelissaM.Mallis,Ph.D.
InstitutesforBehaviorResources,Inc.,Baltimore,
EmmaChilds,Ph.D.
MD,USA
TheUniversityofChicago,DepartmentofPsychiatry
andBehavioralNeuroscience,Chicago,IL,USA JamesT.McKenna,Ph.D.
VABostonHealthcareSystemandHarvardMedical
NicholasDavenport,M.D.,M.P.H. School,ResearchServiceandDepartmentof
NavalSafetyCenter,Norfolk,VA,USA Psychiatry,Brockton,MA,USA
JanineM.Hall-Porter,Ph.D. RaviK.Pasumarthi,Ph.D.
SleepMedicineandResearchCenter,St.Luke’s CenterforNeuroscience,BiosciencesDivision,SRI
Hospital,Chesterfield,MD,USA International,MenloPark,CA,USA
vii
Listofcontributors
BrianPinkston,M.D.,M.P.H. MeganSt.Peters,Ph.D.
MPH,UnitedStatesAirForce,MedicalSupport DepartmentofPsychology,UniversityofMichigan,
Agency,Arlington,VA,USA AnnArbor,MI,USA
PhillipJ.Quartana,Ph.D. RobertE.Strecker,Ph.D.
CenterforMilitaryPsychiatryandNeuroscience, VABostonHealthcareSystemandHarvardMedical
WalterReedArmyInstituteofResearch,SilverSpring, School,ResearchServiceandDepartmentof
MD,USA Psychiatry,Brockton,MA,USA
JohnJ.Renger,Ph.D. LaurenA.Thompson,B.S.
SeniorDirector,SiteLead,Neuroscience ResearchTechnician,MilitaryNutritionDivision,US
Department,MerckResearchLaboratories, ArmyResearchInstituteofEnvironmentalMedicine,
WestPoint,PA,USA Natick,MA,USA
TracyL.Rupp,Ph.D. JamesK.Walsh,Ph.D.
BehavioralBiologyBranch,CenterforMilitary SleepMedicineandResearchCenter,St.Luke’s
PsychiatryandNeuroscience,WalterReedArmy Hospital,Chesterfield,MD,USA
InstituteofResearch,SilverSpring,MD,USA
NancyJ.Wesensten,Ph.D.
MartinSarter,Ph.D. BehavioralBiologyBranch,Centerfor
DepartmentofPsychology,UniversityofMichigan, MilitaryPsychiatryandNeuroscience,Walter
AnnArbor,MI,USA ReedArmyInstituteofResearch,SilverSpring,
MD,USA
JonathanR.L.Schwartz,M.D.
INTEGRISSleepDisordersCenterandUniversityof HarrietdeWit,Ph.D.
OklahomaHealthSciencesCenter,Departmentof TheUniversityofChicago,DepartmentofPsychiatry
Medicine,OklahomaCity,OK,USA andBehavioralNeuroscience,Chicago,IL,USA
MarkR.Smith,Ph.D.,R.PSG.T. KennethP.Wright,Jr.,Ph.D.
DepartmentofIntegrativePhysiology, DepartmentofIntegrativePhysiology,Sleepand
SleepandChronobiologyLaboratory,University ChronobiologyLaboratory,UniversityofColoradoat
ofColoradoatBoulder,CO,USA Boulder,CO,USA
viii