Signalling Pathways in Acute Oxygen Sensing

302 Pages·2006·3.18 MB·English

by  Novartis Foundation

Novartis Foundation Symposium 272
SIGNALLING
PATHWAYS IN
ACUTE OXYGEN
SENSING
2006

SIGNALLING PATHWAYS IN
ACUTE OXYGEN SENSING
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Novartis Foundation Symposium 272
SIGNALLING
PATHWAYS IN
ACUTE OXYGEN
SENSING
2006
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Novartis Foundation Symposium 272
xii +288 pages,56 figures,2 tables
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ISBN-13 978-0-470-01457-8
ISBN-10 0-470-01457-1
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Contents
Symposium on Signalling pathways in acute oxygen sensing, held at the Novartis Foundation,
London, 25–27 January 2005
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium is based on a proposal made by Jeremy Ward
Michael Duchen Chair’s introduction 1
Gregg L.Semenza,Larissa A.Shimodaand Nanduri R.Prabhakar
Regulation of gene expression by HIF-1 2
Discussion 8
Ineke P.Stolze,David R.Moleand Peter J.Ratcliffe Regulation of HIF:
prolyl hydroxylases 15
Discussion 25
General discussion I 33
Daniel Peetand Sarah Linke Regulation of HIF:asparaginyl
hydroxylation 37
Discussion 49
José López-Barneo,Patricia Ortega-Sáenz,José I.Piruat and
María García-Fernández Oxygen-sensing by ion channels and
mitochondrial function in carotid body glomus cells 54
Discussion 64
Keith J.Buckler,Beatrice A.Williams,Rodrigo Varas Orozcoand
Christopher N.Wyatt The role of TASK-like K+channels in oxygen
sensing in the carotid body 73
Discussion 85
v
vi CONTENTS
Nanduri R.Prabhakar,Ying-Jie Peng,Guoxiang Yuanand
Ganesh K.Kumar Reactive oxygen species facilitate oxygen
sensing 95
Discussion 100
C.A.Nurse,J.Buttigieg,R.Thompson,M.Zhangand E.Cutz
Oxygen sensing in neuroepithelial and adrenal chromaffin cells 106
Discussion 114
C.Peers,P.Kang,J.P.Boyle,K.E.Porter,H.A.Pearson,I.F.Smith
andP.J.Kemp Hypoxic regulation of Ca2+signalling in astrocytes and
endothelial cells 119
Discussion 127
General discussion II 131
Paul J.Kemp,Sandile E.J.Williams,Helen S.Mason,Phillippa Wootton,
David E.Iles,Daniela Riccardiand Chris Peers Functional proteomics
of BK potassium channels:defining the acute oxygen sensor 141
Discussion 151
Stephen L.Archer,Evangelos D.Michelakis,Bernard Thébaud,
Sebastien Bonnet,Rohit Moudgil,Xi-Chen WuandE.Kenneth Weir
A central role for oxygen-sensitive K+channels and mitochondria in the
specialized oxygen-sensing system 157
Discussion 171
Gregory B.Waypaand Paul T.Schumacker Role for mitochondrial reactive
oxygen species in hypoxic pulmonary vasoconstriction 176
Discussion 192
Norbert Weissmann,Ralph T.Schermuly,Hossein A.Ghofrani,
Jörg Hänze,Parag Goyal,Friedrich Grimmingerand Werner Seeger
Hypoxic pulmonary vasoconstriction—triggered by an increase in reactive
oxygen species? 196
Discussion 208
General discussion III 214
Alison M.Gurneyand Shreena Joshi The role of twin pore domain and
other K+channels in hypoxic pulmonary vasoconstriction 218
Discussion 228
CONTENTS vii
A.Mark Evans,D.Grahame Hardie,Antony Galione,Chris Peers,
Prem Kumarand Christopher N.Wyatt AMP-activated protein kinase
couples mitochondrial inhibition by hypoxia to cell-specific Ca2+signalling
mechanisms in oxygen-sensing cells 234
Discussion 252
Silke Becker,Gregory A.Knock,Vladimir Snetkov,Jeremy P.T.Ward
and Philip I.Aaronson Role of capacitative Ca2+entry but not Na+/Ca2+
exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary
arteries 259
Discussion 268
Final general discussion 274
Index of contributors 280
Subject index 282