Signaling Mechanisms and Gene Expression in the Ovary

508 Pages·1991·14.326 MB·English

by  Deborah L. Segaloff (auth.), Geula Gibori Ph.D. (eds.)

Serono Symposia, USA
Norwell, Massachusetts
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Geula Gibori
Editor
Signaling Mechanisms
and Gene Expression
in the Ovary
With 207 Figures
Springer-Verlag
New York Berlin Heidelberg London
Paris Tokyo Hong Kong Barcelona
Geula GiOOri, Ph.D.
Department of Physiology and Biophysics
College of Medicine
University of lllinois
Chicago, IL 60680
USA
Proceedings of the Eighth Ovarian Workshop on Regulatory Processes and Gene Expression in the
Ovary, sponsored by Serono Symposia, USA, held July 12 to 14, 1990, in Maryville, Tennessee.
For information on previous volumes, please contact Serono Symposia, USA.
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9 8 7 6 5 4 3 2 1
lSBN-13: 978-1-4612-7830-6 e-lSBN-13: 978-1-4612-3200-1
DOl: 10.1007/978-1-4612-3200-1
PROCEEDINGS OF THE EIGHTH OVARIAN WORKSHOP ON
REGULATORY PROCESSES AND GENE EXPRESSION
IN THE OVARY
Ovarian Workshop Board
Geula Gibori, Ph.D., Chainnan, Eighth Ovarian Workshop
Chicago, lllinois
Eli Y. Adashi, M.D.
Baltimore, Maryland
JoAnne Fortune, Ph.D.
Ithaca, New York
Anne Hirshfield, Ph.D.
Baltimore, Maryland
Aaron Hsueh, Ph.D.
La Jolla, California
Julia Lobotsky, Ph.D.
Bethesda, Maryland
Gordon Niswender, Ph.D.
Fort Collins, Colorado
David W. Schomberg, Ph.D.
Durham, North Carolina
Richard Stouffer, Ph.D.
Beaverton, Oregon
Jerome Strauss, III, M.D., Ph.D.
Philadelphia, Pennsylvania
Organizing Secretary
L. Lisa Kern, Ph.D.
Serono Symposia, USA
100 Longwater Circle
Norwell, Massachusetts
Preface
Since its inception in 1976, the overall goal of the Ovarian Workshop has
been to bring together biologists from various disciplines so that they may
collectively achieve a better understanding of the latest developments and
define important problems in ovarian physiology. The Ovarian Workshop,
which was pioneered by Dr. A. Rees Midgley, has developed into a major
biennial meeting for investigators in the ovarian field.
Largely as a consequence of advances in technology, especially in mo
lecular biology, progress in the area of gene expression and signal transduc
tion has been rapid. The Eighth Ovarian Workshop focused on two major
topics: (1) the expression of hormonally and nonhormonally controlled genes
involved in the functional and morphological differentiation of the cells
forming the ovary and (2) the signaling mechanisms by which endogenous
and exogenous hormones and cytokines affect ovarian differentiation and
steroidogenesis.
The Eighth Ovarian Workshop, held on the campus of Maryville College
in Maryville, Tennessee, July 12 to 14, 1990, was again generously funded
and coordinated by Serono Symposia, USA. I would especially like to thank
Dr. Lisa Kern of Serono for her expert help in organizing this meeting.
The board of directors of the Eighth Ovarian Workshop consisted of Drs.
Eli Adashi, JoAnne Fortune, Anne Hirshfield, Aaron Hsueh, Julia Lobotsky,
Gordon Niswender, David W. Schomberg, Richard Stouffer, and Jerry
Strauss. Their valuable advice and the important roles they played in the
planning of the scientific program are gratefully acknowledged.
GEULAGmORI
vii
Contents
Preface.................................................................................................... vii
Contributors ........................................................................................... xvii
Part I. Gonadotropin Receptors and Transfactors
1. The Gonadotropin Receptors: Structural Insights Learned from
the Cloning of Their cDNAs ........................................................ 3
DEBORAH L. SEGALOFF
2. Hormonal Regulation of Gonadotropin Gene Expression ........... 11
J. LARRY JAMESON, THOMAS W.H. KAY, DEBRA S. DRUST,
LAIRD D. MADISON, AND CHRIS ALBANESE
Part ll. Signaling Pathways in the Ovary
3. Inositol Lipid Metabolism and Calcium Signaling in Rat
Ovarian Cells .............................................. .............. ..................... 25
MARIE R. RODWAY AND PETER C.K. LEUNG
4. Interactions Among the cAMP and IP:JI)AG Intracellular
Signaling Systems in Bovine Luteal Cells .... .......... ..................... 39
JOHN S. DAVIS
5. Variant Diacylglycerol-Dependent Protein Phosphotransferase
Activity in Ovarian Tissues ............................................ .............. 54
EVELYN T. MAIZELS, VICTORIA JACKIW, JOSEPHINE B. MILLER,
RICHARD E. CurLER, JR., ELLEN M. CARNEY, AND
MARY HUNZICKER-DUNN
ix
x Contents
6. Endocrine, Paracrine, and Autocrine Regulators of the
Macaque Corpus Luteum .............................................................. 68
RICHARD L. STOUFFER
7. Steroid Signaling in the Follicular Paracrine System .................. 84
S.G. HILLIER AND I.M. TuRNER
Part III. Hormonal Control and Gene Expression in the Ovary
8. Regulation of Inhibin and Activin Genes in the Rat Ovary ........ 99
JOANNA C. DYKEMA, JASON O. RAHAL, AND KELLY E. MAYO
9. mos Proto-Oncogene Product and Cytostatic Factor ................... 112
NICHOLAS SCHULZ AND GEORGE F. VANDE WOUDE
10. Regulation of Genes Encoding Steroidogenic Enzymes
in the Ovary .................................................................................. 129
MARKUS LAUBER, MICHELLE DEMETER, DAVID STIRLING,
RAYMOND RODGERS, MICHAEL R. WATERMAN, AND
EVAN R. SIMPSON
11. Oxysterols: Regulation of Biosynthesis and Role in Controlling
Cellular Cholesterol Homeostasis in Ovarian Cells ............ ........ 137
JEROME F. STRAUSS, III, HANNAH RENNERT, RITSU YAMAMOTO,
LEE-CHUAN KAO, AND JUAN G. ALVAREZ
Part IV. Relevance of Resident Ovarian White Blood Cells
12. Leukocyte Chemo-Attraction and Periovulatory Follicular
Processes ....................................................................................... 153
W.I. MURDOCH AND R.I. MCCORMICK
13. The Role of IL-l in the Ovary ...................................................... 163
MARY LAKE POLAN, JILL A. LoUKIDES, AND PAMELA NELSON
14. Effects of Bacterial Endotoxin (Lipopolysaccharide) on
FSH-Induced Granulosa Cell Activities ....................................... 170
PAUL E. GOTTSCHALL AND AKIRA ARIMURA
15. TNF a: Altering Thecal and Granulosal Cell Steroidogenesis .... 178
P.F. TERRANOVA, K.F. ROBY, M. SANCHO-TELLO, J. WEED,
AND R. LYLES
Contents xi
16. TNF IX Modulation of Ovarian Steroidogenesis in the Rat ......... 190
DONNA W. PAYNE, ARYE HURWITZ, JEFFREY N. PACKMAN,
CRISTIANA L. ANDREANI, CAROL E. RESNICK, AND
ELI Y. ADASHI
17. Inflammatory Cells in the Rabbit Corpus Luteum: Relationship
to Luteal Involution .... ........ ..... ... ........ ........ ........ ........ .................. 200
R.c.
P. BAGAVANDOSS, WIGGINS, S.L. KUNKEL, D.G. REMICK,
AND P.L. KEYES
Part V. Submitted Manuscripts
18. Two Populations of Steroidogenic Cells in the Theca Layer of
Chicken Ovarian Follicles .... ... ..... ........................ ........ ........ ........ 207
HIROAKI NITTA, YOSHIO OSAWA, AND JANICE M. BAHR
19. Localization of mRN As That Encode Steroidogenic Enzymes
in Bovine Ovaries ......................................................................... 213
R.I. RODGERS AND H.F. RODGERS
20. Fetal Calf Serum: Eliciting Phosphorylation of Ca++j
Calmodulin-Dependent Protein Kinase II in Cultured Rat
Granulosa Cells .... ........ ..... ....... ...... ...... ........ .... .... ................ ......... 218
TAKASHI OHBA, YASUTAKA OHTA, KOHn MIYAZAKI,
HITOSHI OKAMURA, AND EISHICHI MIYAMOTO
21. Differential Regulation of Cytosolic-Free Calcium in Ovine
Small and Large Luteal Cells: Effects on Secretion of
Progesterone .... ........ ........ ......... ............... ........ ..... ........... ........ ...... 225
P.B. HOYER AND J.A. WEGNER
22. Presence of an Endogenous Inhibitor of Protein Kinase C
Throughout Pseudopregnancy in the Rat Ovary .... ........ ........ ...... 234
KATHLEEN M. EYSTER
23. Effects of Gonadotropins and PGE on Ovarian Adenylate
2
Cyclase in Cellular Membrane from Mature Cyclic Cows. ... ...... 240
SERGE-ALAIN WANDJI, M.A. FORTIER, AND M.-A. SIRARD
24. Sphingosine Derivatives, Calmodulin Inhibitors, and TMB-8:
Inhibitors of Adenylate Cyclase Activity in Rat Luteal
Membranes .................................................................................... 248
M. LAHAv, D. BARZILAI, AND O. TOPAZ
xii Contents
25. Cadherins and Ovarian Follicular Development .......................... 254
RIAz FAROOKHI AND OREST W. BLASCHUK
26. Differential Regulation of 3P-HSD and 17P-HSD Expression
in Granulosa Cells ........................................................................ 261
Y. TREMBLAY, B. MARCOTTE, AND J.F. STRAUSS, III
27. Pituitary Hormone Regulation of Ovarian 3 P-HSD Gene
Expression and Activity in the Rat.................... ........................... 268
CLAUDE LABRIE, CELINE MARTEL, JACQUES COuEr,
CLAUDE TRUDEL, V AN Luu-THE, AND FERNAND LABRIE
28. Molecular Cloning of Rat 3P -HSD: Structure of Two Types of
cDNAs and Differential Expression of Corresponding mRNAs
in the Ovary .................................................................................. 274
JACQUES SIMARD, HUI FEN ZHAO, CLAUDE LABRIE,
CLAUDE TRUDEL, ERIC RHEAUME, ERIC DUPONT,
NATHALIE BRETON, V AN Luu-THE, GEORGES PELLETIER, AND
FERNAND LABRIE
29. The Signal Transduction System in Luteotrophic Stimulation of
Expression of the 3P-HSD Gene in Porcine Granulosa Cells in
Culture........................................................................................... 280
P. JORGE CHEDRESE, DANIEL SCHOTT, DAVID ZHANG,
AND BRUCE D. MuRPHY
30. Control of 3P-HSD mRNA and Activity During the Estrous
Cycle in the Bovine Ovary ................................. ,......................... 285
J. CODET, C. MARTEL, V. Luu-THE, M.-A. SIRARD, H.F. ZHAO,
AND F. LABRIE
31. Expression of IGF-I and IGF-I Receptor Gene in the Corpus
Luteum .......................................................................................... 291
T.G. PARMER, M. ZILBERSTEIN, I. KHAN, C. ALBARRACIN,
ANDG.GmORI
32. Expression of IGF-I and IGF-I Receptor Gene in Transformed
Luteal Cells .... ................................................ ................ ........ ....... 297
M. ZILBERSTEIN, T.G. PARMER, S. NELSON, M.P. McLEAN,
L. HARLOW, N. GLEICHER, J.Y. CHou, AND G. GmoRI
33. Relationships of Oocyte Quality and IGF-I in Follicular Fluid
During the Estrual Period in Cattle and Effects of Pre-Estrual
Progestins ............. .......... ...... ........... ................ ...... ....... ......... ........ 304
T. WISE, J .M. GRIZZLE, AND R.R. MAURER