Table Of ContentSIGNAL TRANSDUCTION BY REACTIVE OXYGEN AND NITROGEN SPECIES:
PATHWAYS AND CHEMICAL PRINCIPLES
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Signal Transduction by
Reactive Oxygen and
Nitrogen Species: Pathways
and Chemical Principles
Edited by
Henry Jay Forman
University of Alabama at Birmingham,
Birmingham, Alabama, U.S.A.
Jon Fukuto
University of California at Los Angeles,
Los Angeles, California, U.S.A.
and
Martine Torres
Childrens Hospital Los Angeles Research Institute,
Department of Pediatrics, Keck School of Medicine,
University of Southern California,
Los Angeles, California, U.S.A.
KLUWER ACADEMIC PUBLISHERS
NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW
eBook ISBN: 0-306-48412-9
Print ISBN 1-4020-1117-2
©2004 Kluwer Academic Publishers
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Print ©2003 Kluwer Academic Publishers
Dordrecht
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Contents
Contributors vii
Acknowledgements xiii
Preface xv
Part I: Chemical Principles in Reactive Oxygen and Nitrogen Signaling
1 Redox State and Redox Environment in Biology 1
Freya Q. Schafer and Garry R. Buettner
2 Sulfur and Selenium Catalysis as Paradigms for Redox Regulations 15
Leopold Flohé
3 Thiols of Thioredoxin and Glutaredoxin in Redox Signaling 33
Arne Holmgren
4 Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology 53
Jack R. Lancaster, Jr.
5 Bacterial Peroxiredoxins 80
Leslie B. Poole
Part II: Redox Signaling
6 The Nox Enzymes and the Regulated Generation of Reactive Oxygen 102
Species
Rebecca S. Arnold and J. David Lambeth
7 NO Synthesis and Nos Regulation 119
Ulrich Forstermann, Huige Li, Petra M. Schwarz and Hartmut Kleinert
vi
8 S-Nitrosothiols in Cell Signaling 155
Joseph Loscalzo
9 Hydrogen Peroxide as Intracellular Messenger: Identifcation of 167
Protein Tyrosine Phosphatases and PTEN as Target
Sue Goo Rhee, Seung-Rock Lee, Kap-Seok Yang, Jaeyul Kwon,
and Sang Won Kang
10 4-Hydroxynonenal Signaling 180
Giuseppe Poli, Gabriella Leonarduzzi and Elena Charpotto
11 Ceramide Signaling under Oxidative Stress 194
Tzipora Goldkorn, Tommer Ravid and Edward A Medina
12 Map Kinases in Redox Signaling 223
Atsushi Matsuzawa, Hideki Nishitoh, Kohsuke Takeda and
Hidenori Ichijo
13 Activation of Prostaglandin Biosynthesis: Peroxynitrite vs 237
Hydroperoxides
Lisa Landino
14 Phylogenetic Conservation of the Nrf2-Keap1 Signaling System 256
Xue Zhang, Mark Garfinkel, and Douglas Ruden
Part 3 Physiology and Pathophysiology
15 The NO-Cytochrome C Oxidase Signaling Pathway; Mechanisms and 275
Biological Implications
Sruti Shiva, Anna-Liisa Levonen, Maria Cecilia Barone, and
Victor M. Darley-Usmar
16 The Concept of Compartmentalization in Signaling By Reactive 291
Oxygen Species
Victor J. Thannickal and Barryl Fanburg
17 Role of Mitochondrial Oxygen and Nitrogen Reactive Species in 311
Signaling
Cecilia Giulivi and Merry Jo Oursler
18 Redox Regulation of Gene Expression: Transcriptional Induction 333
of Heme Oxygenase-1
Timothy P. Dalton, Lei He, Howard G. Shertzer and Alvaro Puga
19 Apoptosis Mechanisms Initiated by Oxidative Stress 365
Irene E Kochevar
20 Reactive Oxygen and Nitrogen Species in the Production of 379
Congenital Malformations by Known Teratogenic Agents and Maternal
Conditions
Antonio F Machado, William J. Scott and Michael D. Collins
Index 407
vii
Contributors
Rebecca S. Arnold
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
Atlanta, GA
Cecilia Barone
Department of Pathology
University of Alabama at Birmingham
Birmingham, AL
Garry Buettner
Free Radical Research Institute & ESR Facility
The University of Iowa
Iowa City, IA
Elena Chiarpotto
Department of Clinical and Biological Sciences
University of Turin at S. Luigi Gonzaga Hospital
Turin, Italy
Michael Collins
Department of Environmental Health Sciences
University of California
Los Angeles School of Public Health
Los Angeles, CA
Timothy P. Dalton
Department of Environmental Health
University Cincinnati Medical Center
Cincinnati, OH
viii
Victor M. Darley-Usmar
Department of Pathology
University of Alabama at Birmingham
Birmingham, AL
Barry L. Fanburg
Department of Medicine
Pulmonary & Critical Care Division
Tufts -New England Medical Center
Boston, MA
Leopold Flohé
Department of Biochemistry
Technical University of Braunschweig
Braunschweig, Germany
Henry Jay Forman
Department of Environmental Health Sciences
Univerity of Alabama at Birmingham
Birmingham, AL
Ulrich Förstermann
Department of Pharmacology
Johannes Gutenberg University
Mainz, Germany
Jon Fukuto
Department of Pharmacology
University of California
Los Angeles, CA
Mark Garfinkel
Department of Environmental Health Sciences
Univerity of Alabama at Birmingham
Birmingham, AL
Cecilia Giulivi
Department of Chemistry
University of Minnesota
Duluth, MN
Tzipora Goldkorn
One Shields Avenue
University of California at Davis
Davis, CA
ix
Arne Holmgren
Department of Medical Biochemistry
Medical Nobel Institute for Biochemistry
Stockholm, Sweden
Hidenori Ichijo
Laboratory of Cell Signaling
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Tokyo, Japan
Sang Won Kang
Center for Cell Signaling Research and Division of Molecular Life Sciences
Ewha Women’s University
Seoul, Korea
Hartmut Kleinert
Department of Pharmacology
Johannes Gutenberg University
Mainz, Germany
Irene E. Kochevar
Wellman Laboratories of Photomedicine
Harvard Medical School
Massachusetts General Hospital
Boston, MA
Jaeyul Kwon
Holland Laboratory
American Red Cross
Rockville, MD
David Lambeth
Department of Pathology
Emory University School of Medicine
Atlanta, GA
Jack R. Lancaster , Jr.
Center for Free Radical Biology
University of Alabama at Birmingham
Birmingham, AL
Lisa M. Landino
Department of Chemistry
The College of William and Mary
Williamsburg , VA
