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About Sample Size Calculations in Clinical Research
The authors of this book have a great deal of clinical trial experience in the pharmaceutical industry as well as strong academic backgrounds. For the clinical trial statistician there is now a rich supply of software products to aid in the determination of sample size for a variety of modeling situations. So knowing formulas is no longer important. What is important is to understand the basis for the formulas. This book provides the industrial perspective and the main fixed sample size designs. In this industry trials are constructed to show superiority, noninferiority and equivalence. These three distinct appoaches lead to different results because the null and alternative hypotheses change as you change your goal from superiority to equivalence.This book makes that important distinction and is very scholarly, providing many of the relevant references. Although most clinical trials are still parallel design randomized controlled trials with fixed sample size, there are more and more trials that allow for sequential decisionmaking and hence the actual total sample size can be subject to randomness. The group sequential trials have been the most successful in this regard. But now there are also more flexible "adaptive designs" that are being used. For group sequential designs see the text by Jennison and Turnbull and for the adaptive designs Chow and Chang and a more recent applied text by Chang are very good sources of information. Software packages that are available to do group sequential and adaptive designs are East by Cytel, Seq+Trials by Insightful Corp., PASS by Number Crunchersand ADDPLAN by a German Company. Also statisticians like Mark Chang and Keaven Anderson have created their own routines for adaptive designs using the R programming language.
Detailed Information
| Author: | Shein-Chung Chow, Hansheng Wang, Jun Shao |
|---|---|
| Publication Year: | 2003 |
| ISBN: | 9780824748234 |
| Pages: | 359 |
| Language: | English |
| File Size: | 15.081 |
| Format: | |
| Price: | FREE |
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