Ryanodine Receptors: Structure, function and dysfunction in clinical disease

330 Pages·2005·5.91 MB·English

by  Alexander Kushnir

RYANODINE RECEPTORS
Structure, function and dysfunction in clinical
disease
Developments in Cardiovascular Medicine
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and Immune Mechanisms. 2003 ISBN 1-4020-7438-7
249. Ralph Shabetai: The Pericardium. 2003 ISBN 1-4020-7639-8
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253. Francisco J. Villarreal (ed.): Interstitial Fibrosis In Heart Failure 2004
ISBN 0-387-22824-1
254. Xander H.T. Wehrens; Andrew R. Marks (eds.): Ryanodine Receptors: Structure, function
and dysfunction in clinical disease. 2005 ISBN 0-387-23187-0
Previous volumes are still available
RYANODINE RECEPTORS
Structure, function and dysfunction in clinical
disease
Edited by
Xander H.T. Wehrens and Andrew R. Marks
Dept. of Physiology and Cellular Biophysics, Center for Molecular Cardiology,
College of Physicians and Surgeons of Columbia University, 630 West 168th Street,
P&S 9-401, New York, NY 10032, U.S.A.
Springer
eBookISBN: 0-387-23188-9
Print ISBN: 0-387-23187-0
©2005 Springer Science + Business Media, Inc.
Print ©2005 Springer Science + Business Media, Inc.
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Dedication
This book is dedicated to Eve;
Marnie, Joshua, Daniel & Sarah
Contents
Dedication v
Contributing Authors xi
Preface xv
Foreword xix
1. Evolution of the ryanodine receptor gene family 1
Alexander Kushnir, A.K.M.M. Mollah, Xander H.T. Wehrens
2. Topology and transmembrane organization of ryanodine receptors 9
Guo Ghang Du, David H. MacLennan
3. Three-dimensional reconstruction of ryanodine receptors 25
Zheng Liu, Terence Wagenknecht
4. RyR-DHPR relationships in skeletal and cardiac muscles 35
Clara Franzini-Armstrong
5. The pore of the ryanodine receptor channel 43
Alan J. Williams, S.R. Wayne Chen, William Welch
6. Inter-molecular domain-domain interaction: A key mechanism
for calcium channel regulation of ryanodine receptors 53
Noriaki Ikemoto
viii Ryanodine receptors
7. Regulation of sarcoplasmic reticulum calcium release by luminal
calcium 67
SandorGyörke, Dmitry Terentyev, Serge Viatchenko-Karpinski
8. Cytosolic calcium regulation of single ryanodine receptor 77
channels
Josefina Ramos-Franco, Michael Fill
9. Elementary calcium release events: ryanodine receptor sparks 87
W.J. Lederer, Eric A. Sobie, Silvia Guatimosim, Long-Sheng Song
10. release from the sarcoplasmic reticulum in intact
cardiomyocytes 99
Donald M. Bers, Kenneth S. Ginsburg
11. Stability and instability of release from the SR 111
Mary E. Díaz, Stephen C. O ’Neill, Andrew W. Trafford,
David A. Eisner
12. Ryanodine receptors in smooth muscle 121
Steven O. Marx
13. Functions of RyR3 homologues 131
Yasuo Ogawa, Takashi Murayama, Nagomi Kurebayashi
14. Knockout mice lacking RyR and junctophilin subtypes 141
Hiroshi Takeshima
15. Regulation of ryanodine receptor release by macromolecular
complexes 151
Xander H.T. Wehrens, Stephan E. Lehnart, Andrew R. Marks
16. RyR1 modulation by calmodulin 163
Paula Aracena, Cecilia Hidalgo, Susan L. Hamilton
17. Ryanodine receptor function in inflammation 169
Edmond D. Buck, Barbara E. Ehrlich
18. Ryanoids, receptor affinity and RyR channel subconductance:
Why the discordance? 179
Henry R. Besch Jr., Chun Hong Shao, Keshore R. Bidasee
Ryanodine receptors ix
19. Scorpion peptides as high-affinity probes of ryanodine receptor
function 191
Georgina R. Gurrola, Xinsheng Zhu, Héctor H. Valdivia
20. Redox sensing by the ryanodine receptors 201
Gerhard Meissner, Jonathan S. Stamler
21. Ryanodine receptor dysfunction in the diabetic heart 209
Keshore R. Bidasee, Sarah Ingersoll, Chun Hong Shao
22. Molecular and clinical genetics of RyR1disorders 219
Tommie V. McCarthy, James J.A. Heffron, John Mackrill
23. Pathophysiology of muscle disorders linked to mutations in the 229
skeletal muscle ryanodine receptor
Robert T. Dirksen, Guillermo Avila
24. The dantrolene binding site on RyR1: Implications for clinical 243
therapy
Jerome Parness
25. Ryanodine receptor dysfunction in heart failure and arrhythmias 253
Stephan E. Lehnart, Xander H. T. Wehrens, Andrew R. Marks
26. Stabilization of ryanodine receptor as a novel therapeutic 263
strategy against heart failure
Masafumi Yano, Takeshi Yamamoto, Masunori Matsuzaki
27. Ryanodine receptorantibodies and myasthenia gravis 273
Frederik Romi
References 281
Index 313
Contributing Authors
Donald M. Bers (Chapter 10)
Dept. of Physiology, Loyola University Chicago, Stritch School of
Medicine, 2160 South First Avenue, Maywood, IL 60153
([email protected])
Co-author: Kenneth S. Ginsburg
Henry R. Besch Jr. (Chapter 18)
Dept. of Pharmacology and Toxicology, Indiana University School of
Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 ([email protected])
Co-authors: Keshore R. Bidasee, Chun Hong Shao
Keshore R. Bidasee (Chapter 21)
Dept. of Pharmacology, University of Nebraska Medical Center, 985800
Nebraska Medical Center, DRC 3047, Omaha, NE 6819
(kbidasee @unmc.edu)
Co-authors: Sarah Ingersoll, Chun Hong Shao
Robert T. Dirksen (Chapter 23)
Dept. of Pharmacology and Physiology, University of Rochester Medical
Center, 601 Elmwood Avenue, Rochester, NY 14642
([email protected])
Co-author: Guillermo Avila