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Rozaimah Zain-Hamid & Yazanul Anwar Department of Pharmacology and Therapeutics FFaaccuullttyy ooff MMeeddiicciinnee, Universitas Sumatera Utara OXYTOCIC / UTEROTONIC AGENTS Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara OXYTOCIC / UTEROTONIC AGENTS SSttiimmuullaattiioonn UUTTEERRIINNEE CCOONNTTRRAACCTTIIOONN (cid:155)Induction/auggment dyysfunctional labor (cid:155) Control of post partum hemorhage (cid:155)(cid:155) IInnccoommpplleettee aabboorrttiioonn//aabboorrttiioonn tthheerraappeeuuttiicc Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara OXYTOCIC / UTEROTONIC AGENTS (cid:206)(cid:206) OOxyttociin (cid:206)(cid:206) DDeerriivvaattee ooff EErrggoott AAllkkaallooiiddss (cid:206) Derivate of Prostaglandin Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara Oxytocin Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara OXYTOCIC / UTEROTONIC AGENTS Stimulation of Direct action on pprroossttaaggllaannddiinn uutteerruuss ssmmooootthh mmuussccllee synthesis At terminal stage of pregnancy (((cid:189)(cid:189)(cid:189)(cid:189)(cid:189)(cid:189) ooxxyyttoocciinn rreecceeppttoorr iinn mmyyoommeettrriiuumm)) UUtteerriinnee ccoonnttrraaccttiioonn CCeerrvviixx ddiillaattaattiioonn && ssttrreettcchhiinngg ooff vvaaggiinnaa Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara Uterine contraction CCerviix ddiillattattiion && stretching of vagina SSttiimmuullaattiioonn ooff cceerrvviixx && vvaaggiinnaa (cid:189)(cid:189)(cid:189) oxytocin secretion Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara OXYTOCIN ((PPosteriior piituiitary hhormone)) Pharmacokinetic : * RoA : i.v & buccal absorption * Swallowed → inactive * Not bound to plasma protein * CCaattaabboolliizzeedd bbyy tthhee kkiiddnneeyyss && lliivveerr * Circulating t : 5 minutes 1/2 Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara UTEROTONIC (OXYTOCIN) PPhhaarrmmaaccooddyynnaammiicc :: Alters transmembrane ionic currents in myometrial smooth muscle cells & myyoeppithelial cells of mammaryy alveoli Uterine contraction & lleeaaddss ttoo mmiillkk eejjeeccttiioonn Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara UTEROTONIC (OXYTOCIN) Clinical pharmacology : (cid:63) Diagnostic : ppllaacceennttaall cciirrccuullaattoorryy ccoonnddiittiioonn = Preparation available : Syntocinon & pitocin Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara

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OXYTOCIC / UTEROTONIC AGENTS Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara. OXYTOCIC / UTEROTONIC AGENTS Stimulation

Rozaimah Zain-Hamid & Yazanul Anwar - USU OpenCourseWare PDF

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OXYTOCIC / UTEROTONIC AGENTS Zain-Hamid R & Anwar Y, Faculty of Medicine, Universitas Sumatera Utara. OXYTOCIC / UTEROTONIC AGENTS Stimulation

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