Role of Nutraceuticals in Cancer Chemosensitization (Volume 2) (Cancer Sensitizing Agents for Chemotherapy, Volume 2)

398 Pages·2017·20.809 MB·English

by  Alok Chandra Bharti (editor), Aggarwal Bharat (editor)

Cancer Sensitizing Agents for Chemotherapy
ROLE OF NUTRACEUTICALS IN
CANCER CHEMOSENSITIZATION
VOLUME 2

Cancer Sensitizing Agents
for Chemotherapy
ROLE OF
NUTRACEUTICALS
IN CANCER
CHEMOSENSITIZATION
VOLUME 2
Edited by
A C B
LOK HANDRA HARTI
UniversityofDelhi(NorthCampus),Delhi,andNationalInstituteofCancerPreventionandResearch-
IndianCouncilofMedicalResearch(NICPR-ICMR),Noida,UP,India
B B A
HARAT HUSHAN GGARWAL
InflammationResearchCenter,SanDiego,CA,UnitedStates
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Contents
Contributors ix Conclusion 51
ConflictofInterest 52
About the Editors xi
Acknowledgment 52
About the Series Editor xiii
References 52
Aims and Scope for Series “Cancer FurtherReading 60
SensitizingAgentsforChemotherapy” xv
3. Role of Resveratrol in
Preface xvii
Chemosensitization of Cancer 61
SABIRAMOHAMMED,KUZHUVELILB.HARIKUMAR
1. Pathways Linked to Cancer
Abstract 61
Chemoresistance and Their Targeting
Introduction 61
by Nutraceuticals 1 SourceandChemistryofResveratrol 62
ALOKCHANDRABHARTI,KANCHANVISHNOI, PossibleMolecularMechanismsof
SUKHMAHENDRASINGH, ChemoresistanceinCancer 62
BHARATBHUSHANAGGARWAL ChemosensitizationStudiesUsingResveratrol
inVitro 65
Abstract 1
ChemosensitizationStudiesUsingResveratrol
Introduction 2
inVivo 68
Chemotherapy 3
HumanClinicalTrialsInvolvingResveratrol
Chemoresistance:ProbleminCuringCancer 7
inCancer 70
MechanismofChemoresistance 8
ConclusionandFuturePerspective 71
Chemosensitization:AnApproachtoTarget
References 71
Cancer 14
FurtherReading 76
NutraceuticalsasChemosensitizers:Opportunities
andChallenges 14
4. Role of Tocotrienols in
Conclusion 19
Chemosensitization of Cancer 77
ConflictofInterest 19
Acknowledgments 19 KAZIMHUSAIN,MOKENGEP.MALAFA
References 19
Abstract 77
Introduction 77
2. The Potential of Curcumin: A
SourceandChemistryofTocotrienols 78
Multitargeting Agent in Cancer Cell MolecularTargetsofTocotrienolsinCancer 79
Chemosensitization 31 MechanismsofAnticancerActionof
Tocotrienols 81
DEVIVASHABORDOLOI,AJAIKUMARB.
KUNNUMAKKARA ChemosensitizationbyTocotrienols 83
ChemosensitizationInVitro 85
Abstract 31 ChemosensitizationInVivo 90
Introduction 31 ChemosensitizationinHuman 91
ChemosensitizationStudiesofCurcuminin Conclusion 91
DifferentCancers 33 References 91
v
vi
CONTENTS
5. Chemosensitization by Ursolic Acid: 8. Role of Gambogic Acid in
A New Avenue for Chemosensitization of Cancer 151
Cancer Therapy 99
VIJAYP.KALE,PATRICKJ.GILHOOLEY,SANGITA
PHADTARE,ALINABAVIZADEH,MANOJK.PANDEY
SAHDEOPRASAD,AMITK.TYAGI,
BHARATBHUSHANAGGARWAL
Abstract 151
Abstract 99 Introduction 151
Introduction 99 SourceandChemistryofGA 155
ChemosensitizationofCancerCells 101 MolecularTargetsofGA 155
SafetyandEfficacy 106 Chemo-SensitizationbyGA 159
ConclusionandFutureDirection 106 Conclusion 161
Acknowledgment 107 References 161
References 107
9. Role of Catechins in
Chemosensitization 169
6. Role of Fisetin in
ANANDSWAROOPSHUKLA,ABHIMANYUKUMAR
Chemosensitization 111
JHA,RANIKUMARI,KAVITARAWAT,SAIMASYEDA,
ANJUSHRIVASTAVA
BOKYUNGSUNG
Abstract 169
Abstract 111
Introduction 171
Introduction 112
SourcesofCatechins 172
ChemistryandSourcesofFisetin 113
MolecularTargetsofFisetin 115 StructureandChemistryofCatechins 173
MolecularTargetsoftheCatechin 177
ChemosensitizationbyFisetin 126
ChemosensitizationinVitro 182
Conclusion 133
ConflictofInterest 134 ChemosensitizationinVivo 186
HumanTrials 188
References 134
ImplicationofCatechinsinOtherDiseases 189
Conclusion 192
7. Role of Celastrol in ConflictofInterest 193
Chemosensitization Acknowledgment 193
References 193
of Cancer 141
FurtherReading 198
NURS.AMIRRUDDIN,ALANP.KUMAR,
ADRIANK.K.TEO,GAUTAMSETHI
10. Anticancer Attributes of Silibinin:
Abstract 141 Chemo- and Radiosensitization of
Introduction 141 Cancer 199
BiologicalSourceofCelastrolandIts
ARPITDHEERAJ,DHANIRTAILOR,SURYAP.SINGH,
Chemistry 142
RANAP.SINGH
MolecularTargetsofCelastrol
andItsPotentialMechanism(s) Abstract 199
ofAction 143 Introduction 200
AnticancerandChemosensitizing StructuralCompositionandBioavailabilityof
EffectsofCelastrol 145 Silymarin/Silibinin 202
Conclusions 148 TargetingofVariousAttributesofCancer
ConflictofInterest 148 GrowthandProgression 203
Acknowledgments 148 SilibininasChemosensitizerforCancer
References 148 Cells 210
vii
CONTENTS
SilibininasRadiosensitizerfor SourcesandChemistryofPiperine 260
CancerCells 213 PiperineExtractionandQuantification 261
Conclusions 214 Medicinal&PharmacologicalActivitiesof
References 215 Piperine 262
MechanismofActionofPiperine 264
11. Berberine as an Adjuvant and Chemoresistanceand
Sensitizer to Current Chemosensitisation 270
Chemotherapy 221 InteractionsofPiperineWith
ChemotherapeuticDrugs 275
ALOKCHANDRABHARTI,PRIYANKARAJAN,
Conclusion 279
MOHITJADLI,DEEPTIPANDE,TEJVEERSINGH,
References 280
ANJALIBHAT
FurtherReading 286
Abstract 221
Introduction 222
SourceandChemistry 222 14. Role of Deguelin in
EvidenceShowingthePotentialof Chemoresistance 287
BerberineasaChemosensitizer 223
SANKARJAGADEESHAN,M.MANUPRASAD,
HormeticEffectsofBerberineinInVitro
SHIVAKUMARIASHANAIR
Studies 232
ChemosensitizationInVivoandOther Abstract 287
BeneficialProperties 232 Introduction 287
BerberineinHumanTrials 233 SourceandChemistryofDeguelin 288
Conclusion 234 MolecularTargetsofDeguelin 288
ConflictofInterest 235 ChemosensitizationbyDeguelin 288
Acknowledgments 235 Conclusion 292
References 235 Acknowledgements 293
References 294
12. Role of Emodin in Chemosensitization
of Cancer 241
15. Garcinol: Preclinical Perspective
SUBASHCHANDRAGUPTA,VIPINRAI
Underpinning Chemo- and
Abstract 241 Radiosensitization of Cancer 297
Introduction 243
SANJEEVBANERJEE,MANSIA.PARASRAMKA,
Anti-cancerActivitiesofEmodin 243
SHIVANIB.PARUTHY
Anti-cancerActivitiesofEmodin
Analogues 249 Abstract 297
ChemosensitizationofTumorsbyEmodin 250 Introduction 297
Conclusions 254 GarcinolBioavailability 299
Acknowledgments 255 Garcinol:TherapeuticTargets 299
References 255 SystemicAnticancerandChemo-Sensitizing
EffectsofGarcinol 310
13. Role of Piperine in GarcinolandTRAILSensitization 318
Chemoresistance 259 GarcinolandRadiosensitization 319
GarcinolCombinationWithOther
SANDEEPKUMAR,CHETNABHANDARI,PRERNA
NaturalAgents’onCancer
SHARMA,NAVNEETAGNIHOTRI
Therapy 319
Abstract 259 Conclusion 320
Introduction 259 References 320
viii
CONTENTS
16. ChemopreventiveandAnticancerEffects SourceandChemistryofZerumbone 345
ofPlumbagin:NovelMechanism(s) ZerumbomePromotestheChemosensitization
ofPaclitaxelandCisplatininCancer
viaModulationofCellular
Cells 345
Redox 325
ZerumboneisaDualInhibitorofJAK/STAT3
RAHULCHECKER,RAGHAVENDRA andNF-κBSignaling 346
S.PATWARDHAN,DEEPAKSHARMA, Zerumbone-MediatedChemosensitization
SANTOSHK.SANDUR
InVitroandInVivo 347
Conclusion 347
Abstract 325
References 348
Introduction 325
OccurrenceandIsolationofPlumbagin 327
18. Multitalented Ginger and Its Clinical
AntioxidantPropertiesofPlumbagin 328
ChemopreventiveandAntitumor Development for Cancer
PropertiesofPlumbagin 328 Treatment 351
AntiangiogenicPropertyofPlumbagin 335
ROOPALISAXENA,RITUANEJA
PlumbaginNano-ParticlePreparations 336
Anti-inflammatoryPropertiesof Abstract 351
Plumbagin 337 Introduction 352
ChemosensitizingPropertiesofPlumbagin 337 AlmightyGingertoTreatMightyCancer 353
Conclusion 338 ClinicalTranslationofGinger:Major
References 338 Roadblocks 360
InnovativeModernConceptsto
17. Role of Zerumbone in the FurtherClinicalTranslationof
Chemosensitization of Cancer Ginger 361
Cells 343 Conclusion 364
ConflictofInterest 365
ARUPCHAKRABORTY
References 365
Abstract 343
Index 371
Introduction 343
Contributors
Bharat Bhushan Aggarwal Inflammation Re- Mohit Jadli University of Delhi (North Cam-
searchCenter,SanDiego,CA,UnitedStates pus),Delhi,India
Navneet Agnihotri Panjab University, Chandi- Sankar Jagadeeshan Rajiv Gandhi Centre for
garh,India Biotechnology, Thiruvananthapuram, KL;
Nur S. Amirruddin National University of UniversityofMadras,Chennai,TN,India
Singapore; Institute of Molecular and Cell Abhimanyu Kumar Jha IMS Engineering Col-
Biology,Singapore,Singapore lege,Ghaziabad,UP,India
Ritu Aneja Georgia State University, Atlanta, Vijay P. Kale Battelle Memorial Institute, West
GA,UnitedStates Jefferson,OH,UnitedStates
Sanjeev Banerjee Wayne State University, Alan P. Kumar National University of Singa-
Detroit,MI,UnitedStates pore; National University Health System, Sin-
Chetna Bhandari Panjab University, Chandi- gapore, Singapore; Curtin University, Perth,
WA, Australia; University of North Texas,
garh,India
Denton,TX,UnitedStates
AlokChandraBharti UniversityofDelhi(North
SandeepKumar PanjabUniversity,Chandigarh,
Campus), Delhi; National Institute of Cancer
India
Prevention and Research - Indian Council of
Medical Research (NICPR - ICMR), Noida, RaniKumari UniversityofDelhi,Delhi,India
UP,India Ajaikumar B. Kunnumakkara Indian Institute
Anjali Bhat University of Delhi (North Cam- ofTechnologyGuwahati,Guwahati,AS,India
pus),Delhi,India SukhMahendraSingh BanarasHinduUniver-
DevivashaBordoloi IndianInstituteofTechnol- sity,Varanasi,UP,India
ogyGuwahati,Guwahati,AS,India Mokenge P. Malafa Moffitt Cancer Center,
Arup Chakraborty Roseman University of Tampa,FL,UnitedStates
HealthSciences,Henderson,NV,UnitedStates SabiraMohammed RajivGandhiCentreforBio-
Rahul Checker Bhabha Atomic Research Cen- technology,Thiruvananthapuram,KL,India
tre,Mumbai,MH,India Ali Nabavizadeh Cooper Medical School of
Arpit Dheeraj Jawaharlal Nehru University, RowanUniversity,Camden,NJ,UnitedStates
NewDelhi,India Shivakumari Asha Nair Rajiv Gandhi Centre
Patrick J. Gilhooley Cooper Medical School of for Biotechnology, Thiruvananthapuram, KL,
RowanUniversity,Camden,NJ,UnitedStates India
SubashChandraGupta BanarasHinduUniver- DeeptiPande UniversityofDelhi(NorthCam-
sity,Varanasi,UP,India pus),Delhi,India
KuzhuvelilB.Harikumar RajivGandhiCentre Manoj K. Pandey Cooper Medical School
for Biotechnology, Thiruvananthapuram, KL, of Rowan University, Camden, NJ, United
India States
Kazim Husain Moffitt Cancer Center, Tampa, MansiA.Parasramka MayoClinic,Jacksonville,
FL,UnitedStates FL,UnitedStates
ix