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About Role of Corticotropin-Releasing Factor in Cerebellar Motor Control and Ataxia
1) Deficiency of CRF in the inferior olive induces ataxia-like motor abnormalities such as impaired gait, motor incoordination, and postural imbalance in rats. 2) CRFergic neurons in the inferior olive directly project to the cerebellar nuclei. 3) CRF selectively excites glutamatergic projection neurons rather than GABAergic neurons in the cerebellar interpositus nucleus via two CRF receptors, and promotes cerebellar motor coordination and rescues ataxic motor deficits.
Detailed Information
| Author: | ['shodhganga'] |
|---|---|
| Publication Year: | 2020 |
| Pages: | 15 |
| Language: | English |
| Format: | |
| Price: | FREE |
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