RNA Binding Proteins: New Concepts in Gene Regulation

317 Pages·2002·9.412 MB·English

by  Sung Key Jang, Eckard Wimmer (auth.), Kathryn Sandberg Ph.D., Susan E. Mulroney Ph.D. (eds.)

RNA BINDING PROTEINS:
New Concepts in Gene Regulation
ENDOCRINE UPDATES
Shlomo Melmed, MD., Series Editor
1. E.R. Levin and 1.L. Nadler (eds.): Endocrinology of
Cardiovascular Function. 1998. ISBN: 0-7923-8217-X
2. 1.A. Fagin (ed.): Thyroid Cancer. 1998.
ISBN: 0-7923-8326-5
3. 1.S. Adams and B.P. Lukert (eds.): Osteoporosis: Genetics,
Prevention and Treatment. 1998. ISBN: 0-7923-8366-4.
4. B.-A. Bengtsson (ed.): Growth Hormone. 1999.
ISBN: 0-7923-8478-4
5. C. Wang (ed.): Male Reproductive Function. 1999.
ISBN 0-7923-8520-9
6. B. Rapoport and S.M. McLachlan (eds.): Graves' Disease:
Pathogenesis and Treatment. 2000. ISBN: 0-7923-7790-7.
7. W. W. de Herder (ed.): Functional and Morphological Imaging of
the Endocrine System. 2000. ISBN 0-7923-7923-9
8. H.G. Burger (ed.): Sex Hormone Replacement Therapy. 2001.
ISBN 0-7923-7965-9
9. A. Giustina (ed.): Growth Hormone and the Heart. 2001.
ISBN 0-7923-7212-3
10. W.L. Lowe, lr. (ed.): Genetics of Diabetes Mellitus. 2001.
ISBN 0-7923-7252-2
11. 1.F. Habener and M.A. Hussain (eds.): Molecular Basis of Pancreas
Development and Function. 2001. ISBN 0-7923-7271-9
12. N. Horseman (ed.): Prolactin. 2001
ISBN 0-7923-7290-5
13. M. Castro (ed.): Transgenic Models in Endocrinology. 2001
ISBN 0-7923-7344-8
14. R. Bahn (ed.): Thyroid Eye Disease. 2001
ISBN 0-7923-7380-4
15. M.D. Bronstein (ed.): Pituitary Tumors in Pregnancy
ISBN 0-7923-7442-8
16. K. Sandberg and S.E. Mulroney (eds.): RNA Binding Proteins:
New Concepts in Gene Regulation. 2001. ISBN 0-7923-7612-9
RNA BINDING PROTEINS:
New Concepts in Gene Regulation
Edited by
Kathryn Sandberg, PhD
Departments ofM edicine and Physiology & Biophysics
Georgetown University School ofM edicine
Washington, DC
and
Susan E. Mulroney, PhD
Depa~tment ofP hysiology & Biophysics
Georgetown University School ofM edicine
Washington, DC
"~.
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
RNA binding proteins: new concepts in gene regulation 1 edited by Kathryn Sandberg
and Susan E. Mulroney.
p. cm. --(Endocrine updates; 16)
Includes bibliographical references and index.
ISBN 978-1-4419-4935-6 ISBN 978-1-4757-6446-8 (eBook)
DOI 10.1007/978-1-4757-6446-8
1. Genetic regulation. 2. RNA-protein interactions I. Sandberg, Kathryn. II. Mulroney,
Susan E. III. Series.
QH450 .R63 2002
572.8'65--dc21
2001054415
Copyright © 2002 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 2002
Softcover reprint of the hardcover 1s t edition 2002
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system
or transmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise,
without the prior written permission of the publisher, Springer Science+Business Media, LLC.
Printed on acid-free paper.
Contents
Contributors .............................................................................. vii
Preface ....................................................................................... xiii
Acknowledgements ..................................................................... xv
Section I: Translational Control
1. The role of RNA-binding proteins in IRES-dependent translation
Sung Key Jang and Eckard Wimmer... ... ... ... ... ... . . . . . . .... 1
2. Translational regulation of masked maternal mRNAs in early
development
Nancy Standart...... .................................... ............ 35
3. Poly-C binding proteins: Cellular regulators of mRNA
fate and function
Andrea V. Gamarnik and Raul Andino........................... 53
4. Autoregulation of protein synthesis by translation
Guim Kwon, Guang Xu, Wilhelm S. Cruz,
Connie A. Marshall and Michael L. McDaniel... ... ... ........ 71
5. Translational initiation of ornithine decarboxylase mRNA
Lo Persson and Koichi Takao............... ... ................... 87
Section II: mRNA Metabolism
6. Regulation ofmRNA stability by AUFI
Gerald M Wilson and Gary Brewer... ... ... ..... . . . . . . . . .. ... ... 101
7. RNA binding by members of the 70-kDa family
of molecular chaperones
Christine Zimmer, Eszter Nagy, John R Subjeck,
and Tamas Benics.................. ... ... .......................... 119
8. Post-transcriptional control of type-l plasminogen
activator inhibitor mRNA
Joanne H Beaton and Thomas D. Gelehrter ................... 135
9. Post-transcriptional control of the GAP-43 mRNA
by the ELAV -like protein HuD
Nora Perrone-Bizzozero and Rebecca Keller .................. 157
Section III: Hormonal and Homeostatic Regulation
10. RNA-dependent protein kinases
Raymond Petryshyn, Sergie Nekhai,
and Evelio D. Perez-Albuerne .................................... 175
11. Regulation of messenger RNA-binding proteins by
protein kinases A and C
Richard A. Jungmann... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 193
12. Post-transcriptional regulation of iron metabolism
Tracey A. Rouault.................................................. 213
13. Cytochrome P450 RNA-protein interactions
Matti A. Lang and Franr;oise Raffalli-Mathieu ................. 225
14. Site-specific cleavage of insulin-like growth factor II mRNAs
Erwin L. van Dijk and P. Elly Holthuizen ...................... 239
15. Hormonal regulation of the EGF/receptor system
Stephen W Spaulding and Lowell G. Shejlin .................. 255
16. The role of RNA binding proteins in tumorigenesis
Sreerama Shetly., .................................................. 271
17. Regulation of G-protein coupled receptor cytosolic
mRNA binding proteins
Kathyrn Sandberg, Zheng Wu, Hong Ji,
Eric Hernandez and Susan E. Mulroney ........................ 285
Index ............................................................................. 307
VI
Contributors
Raul Andino, Ph.D.
Associate Professor
Department ofM icrobiology and Immunology
University of California at San Francisco, Box 0414
San Francisco, CA 94143-0414
Wilhelm S. Cruz, Ph.D.
Instructor
Biology Department
Campus Box 8118
Washington University
Rebstock 130
St Louis, MO 63110
Gary Brewer, Ph.D.
Associate Professor
Department ofM olecular Genetics and Microbiology
UMDNJ-Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ 08854
Andrea V. Gamarnik, Ph.D.
Group Leader
1nstituto de Investigaciones Bioquimicas
Fundacion Campomar
Av Patricias Argentinas 435
Capital Federal, Buenos Aires, Argentina
Thomas D. Gelehrter, M.D.
Professor and Chair
Department ofH uman Genetics
University ofM ichigan Medical School
4909 Buhi, Box 0618
1241 E. Catherine Street
Ann Arbor, MI 48109-0618
Tamas Benies, M.D., Ph.D.
Senior StajJScientist Assistant Professor
Department ofM olecular Biology Dept. ofM edical Immunol and Microbiol.
1NTERCELL, Inc. Faculty ofM edicine
Rennweg 95B University ofP ees, Szigeti u. 12
A-1030 Vienna, Austria 7643 Pecs, Hungary
Joanne H. Heaton, M.S.
Department ofH uman Genetics
University ofM ichigan Medical School
4909 Buhl, Box 0618
1241 E. Catherine Street
Ann Arbor, MI 48109-0618
Eric Hernandez
Graduate Student
Department ofM icrobiology and Immunology
Georgetown University
4000 Reservoir Road, NW
Washington, DC 20007-2145
P. Elly Holthuizen, Ph.D.
Senior Scientist
Department ofP hysiological Chemistry
University Medical Center Utrecht
Universiteitsweg 100
3584 CG Utrecht
The Netherlands
Sung Key Jang, Ph.D.
Associate Professor
Department ofL ife Sciences
Pohang University ofS cience and Technology
Hyoja-Dong San 31, Pohang
Kyungbuk 790-784, Korea.
Hong Ji, M.D.
Assistant Professor
Department ofP hySiology
Georgetown University
4000 Reservoir Road, NW
Washington, DC 20007-2145
Richard A. Jungmann, Ph.D.
Professor
Department ofC ell and Molecular Biology
Northwestern University Medical School
Olson Pavilion 8321
303 East Chicago Avenue
Chicago,IL 60611-3008
Rebecca Keller, Ph.D.
Research Assistant Professor
Department ofC hemistry
Clark Hall 104
University ofN ew Mexico School ofM edicine
Albuquerque, NM 87131
viii
Guim Kwon, Ph.D.
Research Instructor
Department ofP athology and Immunology
Washington University School ofM edicine
660 S. Euclid Avenue
St Louis, MO 63110
Matti A. Lang. Ph.D.
Professor and Chair
Department ofB iochemistry
Faculty ofP harmacy
Biomedical Centrum Box 578
University of Uppsala
Uppsala, Sweden
Connie A. Marshall, B.S.
Research Associate
Department ofP athology and Immunology
Campus Box 8118
Washington University School ofM edicine
660 S. Euclid Avenue
St Louis, MO 63 I1 0
Michael L. McDaniel, Ph.D.
Professor
Department ofP athology and Immunology
Campus Box 8118
Washington University School ofM edicine
660 S. Euclid Avenue
St Louis, MO 63 I1 0
Susan E. Mulroney, Ph.D.
Associate Professor
Department ofP hysiology & Biophysics
Georgetown University School ofM edicine
3900 Reservoir Rd, NW Rm 253 Basic Science Building
Washington, DC 20007
Eszter Nagy, M.D., Ph.D.
Senior StaffS cientist Assistant Professor
Department ofM olecular Biology Dept. ofC linical Biochemistry
INTERCELL, Inc. Faculty ofM edicine
Rennweg 95B University ofP ecs, Szigeti u. 12
A-J030 Vienna, Austria 7643 Pecs, Hungary
Sergie Nekhai, Ph.D.
Assistant Professor
Sickle Cell Center
Howard University
2121 Georgia Avenue, NW
Washington, DC 20059
ix
Evelio D. Perez-Albuerne, M.D., Ph.D.
Attending Physician
Department ofH ematology/Oncology
Children's National Medical Center
III Michigan Avenue, NW
Washington, DC 20010
Nora Perrone-Bizzozero, Ph.D.
Professor
Department ofN euroscience
University ofN ew Mexico School ofM edicine
915 Camino de Salud NE
Albuquerque, NM 87131-5223
Lo Persson, Ph.D.
Professor
Department ofP hysiology and Neuroscience
University ofL und
BMC F:I3
S-22184 Lund, Sweden
Raymond A. Petryshyn, Ph.D.
Scientific Review Administrator
Grants Review Branch
Division ofE xtramural Activities
National Cancer Institute
Room 8133
6116 Executive Blvd. MSC 8328
Bethesda, MD 20892
Fran~oise Raffalli-Mathieu, Ph.D.
Department ofB iochemistry
Faculty ofP harmacy
Biomedical Centrum Box 578
University of Uppsala
Uppsala, Sweden
Tracey A. Rouault, M.D.
Chief
Section on Human Iron Metabolism
Cell Biology and Metabolism Branch
National Institute ofC hild Health and Human Development
Building 18, Room 101
Bethesda, MD 20892
x