Table Of ContentRheumatology and
the Kidney
Oxford Clinical Nephrology Series
Cancer and the Kidney: The frontier of nephrology and oncology, Second
Edition
Edited by Eric P. Cohen
Chronic Kidney Disease: A practical guide to understanding and
management
Edited by Meguid El Nahas and Adeera Levin
Lupus Nephritis, Second Edition
Edited by Edmund J. Lewis, Melvin M. Schwartz, Stephen M. Korbet, and
Daniel Tak Mao Chan
Rheumatology and the Kidney, Second Edition
Edited by Dwomoa Adu, Paul Emery, and Michael Madaio
The Spectrum of Mineral and Bone Disorders in Chronic Kidney Disease,
Second Edition
Edited by Klaus Olgaard, Isidro B. Salusky, and Justin Silver
Treatment of Primary Glomerulonephritis, Second Edition
Edited by Claudio Ponticelli and Richard J. Glassock
Rheumatology and
the Kidney
SECOND EDITION
Edited by
Dwomoa Adu
Paul Emery
Michael Madaio
1
1
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Second Edition published in 2012
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Preface
M any diseases affect the joints as well as the kidneys. The aetiology of these multisys-
tem diseases includes autoimmunity, virus infection and the complications of drugs.
There have been major recent advances in the understanding of the pathogenesis,
diagnosis and treatment of these disorders but these are only available in disparate
publications. R heumatology and the Kidney brings together internationally recognized
experts in a broad range of disciplines who provide a concise update on these disor-
ders in one publication. Areas covered include lupus nephritis, vasculitis, systemic
sclerosis, amyloidosis, virus associated disease and the rheumatological complications
of renal disease. Other chapters cover amyloidosis and Hepatitis B and C associated
systemic disease. Finally there are chapters on the nephrotoxicity of drugs used in the
treatment of rheumatologic diseases and also on rheumatologic complications of
dialysis and renal transplantation. The book should be useful to rheumatologists and
nephrologists and also to internal medicine physicians and trainees who are interested
in the management of patients with autoimmune disorders. The book is updated
from the previous edition to include sections on new classifications of diseases, as well
as information on new treatments.
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Contents
Contributors ix
Abbreviations xiii
1 Clinical presentation and assessment of disease
activity in lupus nephritis 1
Venkat Reddy and David Isenberg
2 Lupus nephritis: Histopathology 11
David J. Cimbaluk and Melvin M. Schwartz
3 Lupus nephritis: Complement in lupus 27
Michael G. Robson
4 Pathogenesis of lupus nephritis 39
N. Stanley Nahman, Jr and Michael P. Madaio
5 Evidence-based treatment of lupus nephritis 57
Wai Y. Tse and Dwomoa Adu
6 The role of biologicals in the treatment of lupus nephritis 69
Amara N. Ezeonyeji and David A. Isenberg
7 Systemic lupus erythematosus (SLE) in pregnancy 79
Aisha Lateef and M. Petri
8 Renal involvement in the anti-phospholipid syndrome 93
Joyce Rauch and Jerrold S. Levine
9 Vasculitis classification 117
J. Charles Jennette, Ronald J. Falk, and Adil Hussein Gasim
10 The immunopathogenesis of vasculitis 131
Andrew McClean and C.O.S. Savage
11 Pathology of vasculitis: Wegener’s granulomatosis, microscopic
polyangiitis, renal limited vasculitis, and Churg–Strauss syndrome 145
Franco Ferrario and Maria Pia Rastaldi
12 Assessment of disease activity and damage in the
ANCA-associated systemic vasculitides 153
Joanna C. Robson, Ravi Suppiah, and Raashid A. Luqmani
13 The clinical presentation and treatment of renal vasculitis 163
David Jayne
14 Polyarteritis nodosa: Clinical characteristics,
outcome, and treatment 181
Loïc Guillevin
viii CONTENTS
15 Vasculitis (ANCA negative): Henoch–Schönlein purpura 195
Rosanna Coppo and Alessandro Amore
16 Takayasu arteritis 209
Vivekanand Jha and Kirpal S. Chugh
17 Systemic sclerosis: Immunopathogenesis,
clinical features, and treatment 227
Voon H. Ong and Christopher P. Denton
18 Amyloidosis: Immunopathogenesis and diagnosis 249
H.J. Lachmann and P.N. Hawkins
19 Amyloidosis: Rheumatic disease and amyloid;
clinical features and treatment 263
H.J. Lachmann and P.N. Hawkins
20 Primary amyloidosis (AL) 283
Robert A. Kyle
21 Light-chain and heavy-chain deposition diseases 293
Pierre Ronco and Pierre Aucouturier
22 Hepatitis C virus-associated mixed cryoglobulinaemia 303
Edgar D. Charles
23 Hepatitis B-associated renal diseases 317
Kar Neng Lai and Sydney C.W. Tang
24 Rheumatic complications of HIV infection 333
Ulrich A. Walker
25 Renal complications of HIV infection 343
Susan E. Collins, Thomas Hays, and Paul Klotman
26 NSAID nephrotoxicity 353
Wai Y. Tse and Dwomoa Adu
27 Nephrotoxicity of drugs used in rheumatology:
Analgesic nephropathy 371
Marc E. De Broe
28 Renal toxicity of anti-rheumatic drugs 385
Sarah Bingham and Paul Emery
29 Rheumatological diseases associated with interstitial nephritis 399
Alan D. Salama and Charles D. Pusey
30 Management of gout in the patient with renal disease 415
Philip Courtney and Michael Doherty
31 Nephrogenic systemic fibrosis 429
Teresa K. Chen and Derek M. Fine
32 Rheumatological complications of renal disease
and transplantation 441
Sharmin Nizam, Zunaid Karim, and Paul Emery
Index 455
Contributors
Dwomoa Adu Rosanna Coppo
Renal Unit, Korle Bu Hospital, Accra, Nephrology, Dialysis and
Ghana Transplantation Unit, Regina
Margherita University Hospital,
Alessandro Amore
Torino, Italy
Nephrology, Dialysis and
Transplantation Unit, Regina Philip Courtney
Margherita University Hospital, Torino, Department of Rheumatology,
Italy Nottingham University Hospital Trust,
UK
Pierre Aucouturier
Université Pierre & Marie Curie, Marc E. De Broe
INSERM UMRS 938, Laboratory of Pathophysiology,
Paris, France University of Antwerp, Belgium
Sarah Bingham Christopher P. Denton
Leeds Teaching Hospitals NHS Trust, UK Centre for Rheumatology and
Connective Tissue Diseases, UCL
Edgar D. Charles
Medical School, London, UK
Center for the Study of Hepatitis C,
Laboratory of Virology and Infectious Michael Doherty
Disease, The Rockefeller University, Academic Rheumatology,
New York, USA University of Nottingham,
City Hospital
Teresa K. Chen
Nottingham, UK
Department of Medicine, Division of
Nephrology, Johns Hopkins University Paul Emery
School of Medicine, Baltimore, USA Section of Musculoskeletal Disease,
Leeds Institute of Molecular Medicine,
Kirpal S. Chugh
University of Leeds;
Department of Nephrology,
NIHR Leeds Musculoskeletal
Postgraduate Institute of Medical
Biomedical Research Unit,
Education and Research, Chandigarh,
Leeds Teaching Hospitals Trust,
India
Leeds, UK
David J. Cimbaluk
Amara N. Ezeonyeji
Department of Pathology, Rush
Department of Rheumatology,
University Medical Center, Chicago,
University College London, UK
USA
Ronald J. Falk
Susan E. Collins
Division of Nephrology and
Department of Medicine,
Hypertension, University of North
Division of Nephrology
Carolina, Chapel Hill, USA
Mount Sinai School of Medicine,
New York, USA
