Rheumatoid arthritis

167 Pages·2013·4.29 MB·English

Rheumatoid Arthritis:
The link between thyroid dysfunction,
cardiovascular disease and B cell targeting

Hennie G. Raterman
The printing of this thesis was supported financially by:
AbbVie, Amgen, Dutch Arthritis foundation, Pfizer, Reade center for
rehabilitation and rheumatology, Roche, Schildklier Organisaties Nederland,
Teva Nederland bv and UCB Pharma bv.

Copyright © Hennie G. Raterman, Monnickendam, the Netherlands, 2013

All rights reserved. No part of this publication may be reproduced, stored in a
retrieval system of any nature, or transmitted in any form or by any means,
without prior permission of the author

Cover design: Chantal Snackey
Layout: Hennie Raterman
English auditing: Tessa Dorhout

Printed by: Ipskamp drukkers

ISBN: 978-94-6191-814-7
VRIJE UNIVERSITEIT

Rheumatoid Arthritis:
The link between thyroid dysfunction,
cardiovascular disease and B cell targeting

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam,
op gezag van de rector magnificus
prof.dr. F.A. van der Duyn Schouten,
in het openbaar te verdedigen
ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde
op maandag 16 september 2013 om 13.45 uur
in de aula van de universiteit,
De Boelelaan 1105

door
Hendricus Gerardus Raterman

geboren te Amsterdam
promotor: prof.dr. B.A.C. Dijkmans

copromotoren: prof.dr. W.F. Lems
dr. M.T. Nurmohamed
dr. A.E. Voskuyl

Contents
INTRODUCTION Rheumatoid arthritis: The link between thyroid 9
dysfunction, cardiovascular disease and B cell targeting

SECTION 1 Thyroid dysfunction and rheumatoid arthritis: more 23
than comorbidity
Chapter 1.1 Hypothyroidism and cardiovascular diseases in rheumatoid 25
arthritis
A Rheumatoid arthritis is associated with a high prevalence 25
of hypothyroidism that amplifies its cardiovascular risk
Annals of the Rheumatic Diseases 2008 Feb; 67(2):229-32
B Coexistence of hypothyroidism with inflammatory arthritis 37
is associated with cardiovascular disease in women
Annals of the Rheumatic Diseases 2012 Jul;71(7):1216-8
Chapter 1.2 The metabolic syndrome is amplified in hypothyroid 47
rheumatoid arthritis patients: a cross-sectional study
Annals of the Rheumatic Diseases 2010 Jan;69(1):39-42
Chapter 1.3 Thyroid peroxidase antibodies in rheumatoid arthrtitis 59
A Increased prevalence of antithyroid antibodies in 59
rheumatoid arthritis (RA) patients with a low prevalence of
hormonal alterations
Autoimmunity 2008 Aug;41(5):337
B Increased progression of carotid intima media thickness in 63
thyroid peroxidase antibodies positive rheumatoid arthritis
patients
Submitted
Chapter 1.4 Thyroid function upon biological treatment in rheumatoid 77
arthritis
A Improvement of thyroid function in hypothyroid patients 77
with rheumatoid arthritis after 6 months of adalimumab
treatment: a pilot study.
Journal of rheumatology 2011 Feb;38(2):247-51
B Rituximab and thyroid function 91
Archives of internal Medicine 2009 Jun 8;169(11):1073-4
SECTION 2 Rituximab in rheumatoid arthritis: more than B cell 97
depletion
Chapter 2.1 HDL protein composition alters from proatherogenic into less 99
atherogenic and proinflammatory in rheumatoid arthritis
patients responding to rituximab
Annals of the Rheumatic Diseases 2013 Apr;72(4):560-5

Chapter 2.2 Pharmacogenomics in rituximab treated rheumatoid arthritis 119
patients

A Pharmacological induction of interferon type I activity 119
following treatment with rituximab determines clinical
response in rheumatoid arthritis
Annals of the Rheumatic Diseases 2011 Jun;70(6):1153-9

B Interferon type I signature may predict non response 139
upon rituximab in rheumatoid arthritis patients
Arthritis Research and Therapy 2012 Apr 27;14(2):R95
SUMMARY & DISCUSSION 159

DUTCHSUMMARY 175
(NEDERLANDSE
SAMENVATTING)

ACKNOWLEDGEMENTS 189
(DANKWOORD)

ABOUT THE AUTHOR 195

INTRODUCTION