Retinoids in Dermatology

245 Pages·2019·5.67 MB·\245

by  Ayse Serap Karadag (Editor), Berna Aksoy (Editor), Lawrence Charles Parish (Editor)

Retinoids in Dermatology
Series in Dermatological Treatment
About the Series
Published in association with the Journal of Dermatological Treatment, the Series in Dermatological Treatment keeps readers up
to date with the latest clinical therapies to improve problems with the skin, hair, and nails. Each volume in the series is prepared
separately and typically focuses on a topical theme. Volumes are published on an occasional basis, depending on the emergence of
new developments.
Retinoids in Dermatology
Ayse Serap Karadag, Berna Aksoy, and Lawrence Charles Parish
Facial Skin Disorders
Ronald Marks
Dermatologic Reactions to Cancer Therapies
Gabriella Fabbrocini, Mario E. Lacouture, and Antonella Tosti
Acne Scars: Classification and Treatment, Second Edition
Antonella Tosti, Maria Pia De Padova, Gabriella Fabbrocini, and Kenneth Beer
Phototherapy Treatment Protocols, Third Edition
Steven R. Feldman and Michael D. Zanolli
Dermatoscopy in Clinical Practice: Beyond Pigmented Lesions, Second Edition
Giuseppe Micali and Francesco Lacarrubba
Nail Surgery
Bertrand Richert, Nilton Di Chiacchio, and Eckart Haneke
Abdominal Stomas and Their Skin Disorders, Second Edition
Callum C. Lyon and Amanda Smith
Textbook of Atopic Dermatitis
Sakari Reitamo, Thomas A. Luger, and Martin Steinhoff
For more information about this series please visit: https://www.crcpress.com/
Series-in-Dermatological-Treatment/book-series/CRCSERDERTRE
Retinoids in Dermatology
Edited by
Ayse Serap Karadag, MD
Department of Dermatology
Istanbul Medeniyet University
Faculty of Medicine
Göztepe Training and Research Hospital
Istanbul, Turkey
Berna Aksoy, MD
Department of Dermatology
Bahçeşehir University
Faculty of Medicine
Istanbul, Turkey
Lawrence Charles Parish, MD, MD (Hon)
Department of Dermatology and Cutaneous Biology
Sidney Kimmel Medical College at Thomas Jefferson University
and Jefferson Center for International Dermatology
Philadelphia, Pennsylvania, USA
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Library of Congress Cataloging-in-Publication Data
Names: Karadag, Ayse Serap, editor. | Aksoy, Berna, editor. |
Parish, Lawrence Charles, editor. Title: Retinoids in dermatology / edited by Ayse Serap Karadag,
Berna Aksoy, Lawrence Charles Parish.
Other titles: Series in dermatological treatment.
Identifiers: LCCN 2019034117 (print) | LCCN 2019034118 (ebook) | ISBN
9781138314771 (hardback ; alk. paper) | ISBN 9780429456732 (ebook)
Subjects: MESH: Skin Diseases--drug therapy | Retinoids--therapeutic use | Retinoids--pharmacology
Classification: LCC RL120.R48 (print) | LCC RL120.R48 (ebook) | NLM WR 650 | DDC 616.5/061--dc23
LC record available at https://lccn.loc.gov/2019034117
LC ebook record available at https://lccn.loc.gov/2019034118
Visit the Taylor & Francis Web site at
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and the CRC Press Web site at
http://www.crcpress.com
Contents
Contributors vii
1. The Background of Retinoids .......................................................................................................................................................1
Ayse Serap Karadag, Berna Aksoy, and Lawrence Charles Parish
2. Mechanism of Action of Vitamin A ..............................................................................................................................................3
Sandra Maria Barbalho
3. Mechanism of Action of Topical Retinoids ..................................................................................................................................7
Sümeyre Seda Ertekin and Mehmet Salih Gurel
4. Mechanism of Action of Isotretinoin ..........................................................................................................................................13
Bodo C. Melnik
5. Mechanism of Action of Acitretin ...............................................................................................................................................27
Kaitlyn Lam and Ronald Vender
6. Mechanism of Action of Bexarotene ...........................................................................................................................................33
Catherine M. Ludwig, Claire Wilson, Brandon Roman, and Maria M. Tsoukas
7. Mechanism of Action of Alitretinoin ..........................................................................................................................................37
Ömer Faruk Elmas and Necmettin Akdeniz
8. Effects of Retinoids at the Cellular Level (Differentiation, Apoptosis, Autophagy, Cell Cycle Regulation,
and Senescence) ............................................................................................................................................................................41
Jelena Popovic
9. Effects of Retinoids at the Systemic Level .................................................................................................................................51
Sandra Maria Barbalho and Letícia Maria Pescinini-Salzedas
10. New Aspects of Isotretinoin Teratogenicity ...............................................................................................................................55
Bodo C. Melnik
11. Mucocutaneous Side Effects ........................................................................................................................................................61
Tugba Kevser Uzuncakmak and Ayse Serap Karadag
12. Ophthalmologic Side Effects .......................................................................................................................................................67
Remzi Karadag and Fehim Esen
13. Musculoskeletal Side Effects .......................................................................................................................................................73
Filiz Cebeci Kahraman, Vefa Aslı Turgut Erdemir, and Melek Aslan Kayıran
14. Neurologic Side Effects ................................................................................................................................................................79
Evren Burakgazi-Dalkilic
15. Psychiatric Side Effects ................................................................................................................................................................83
Joshua Schimmel, Evren Burakgazi-Dalkilic, and Hatice Burakgazi-Yilmaz
16. Gastrointestinal Side Effects .......................................................................................................................................................89
Esra Adışen, Burcu Beksaç, and Mehmet Ali Gürer
17. Endocrine and Metabolic Side Effects .......................................................................................................................................93
Ayse Serap Karadag, Emin Ozlu, and Bodo C. Melnik
v
vi Contents
18. Other Systemic Side Effects: Cardiovascular, Pulmonary, Otolaryngorhinologic, Genitourinary, Renal, and
Immunologic ...............................................................................................................................................................................105
Emin Ozlu, Akif Bilgen, and Ayse Serap Karadag
19. Retinoids in Acne ........................................................................................................................................................................111
Ruta Ganceviciene and Christos C. Zouboulis
20. Retinoids in Hidradenitis Suppurativa/Acne Inversa .............................................................................................................121
Uwe Wollina, Piotr Brzezinski, and André Koch
21. Retinoids in Rosacea ..................................................................................................................................................................125
Marius Rademaker and Harriet Cheng
22. Retinoids in Hair Disorders ......................................................................................................................................................129
Brent J. Doolan and Rodney Sinclair
23. Retinoids in Psoriasis .................................................................................................................................................................135
Uwe Wollina, Piotr Brzezinski, and André Koch
24. Retinoids in Keratinization Disorders .....................................................................................................................................145
Ümit Türsen and Belma Türsen
25. Retinoids in Antiaging Therapy ................................................................................................................................................157
Zehra Aşiran Serdar and Ezgi Aktaş Karabay
26. Retinoids in Other Skin Diseases ..............................................................................................................................................163
Uwe Wollina, Piotr Brzezinski, and André Koch
27. Retinoids in Lymphoma .............................................................................................................................................................171
Robert Duffy and Joya Sahu
28. Retinoids in Cutaneous Chemoprophylaxis ............................................................................................................................177
Robert Duffy and Joya Sahu
29. Guide to Good Clinical Practice for Vulnerable Populations (Infancy, Childhood, Fertile Period, Elderly) ..................183
Elif Yildirim and Berna Aksoy
30. Retinoids and Concomitant Surgery ........................................................................................................................................189
H. Mete Aksoy
31. Retinoids and Concomitant Aesthetic Procedures .................................................................................................................197
Zekayi Kutlubay, Ayşegül Sevim Keçici, and Yalçın Tüzün
32. Laboratory and Clinical Follow-Up .........................................................................................................................................201
Nadide Burcu Öztürk and Berna Aksoy
33. Teratogenicity and Registry Programs ....................................................................................................................................207
Reese L. Imhof and Megha M. Tollefson
34. Management of Vitamin A and Retinoid Side Effects............................................................................................................213
Asli Tatliparmak and Berna Aksoy
35. Future and Novel Unexplored Indications of Retinoids .........................................................................................................217
Kabir Sardana and Ananta Khurana
Index ....................................................................................................................................................................................................227
Contributors
Esra Adışen Evren Burakgazi-Dalkilic
Department of Dermatology Department of Neurology
Gazi University Cooper Medical School of Rowan University
Faculty of Medicine Cooper University Hospital
Ankara, Turkey Camden, New Jersey
Necmettin Akdeniz Hatice Burakgazi-Yilmaz
Department of Dermatology Department of Psychiatry
Istanbul Medeniyet University Cooper Medical School of Rowan University
Faculty of Medicine Cooper University Hospital
Göztepe Training and Research Hospital Camden, New Jersey
Istanbul, Turkey
Harriet Cheng
Berna Aksoy Department of Dermatology
Department of Dermatology Auckland City Hospital
Bahçeşehir University Auckland, New Zealand
Faculty of Medicine
Istanbul, Turkey Brent J. Doolan
The Royal Children’s Hospital
H. Mete Aksoy Skin & Cancer Foundation Inc.
Department of Plastic, Reconstructive, The Royal Melbourne Hospital
and Aesthetic Surgery Melbourne, Australia
Bahçeşehir University
Faculty of Medicine Robert Duffy
Istanbul, Turkey Department of Dermatology and Cutaneous Biology
Thomas Jefferson University
Sandra Maria Barbalho Philadelphia, Pennsylvania
Department of Biochemistry and Nutrition
School of Medicine Ömer Faruk Elmas
University of Marília Department of Dermatology
Faculty of Food Technology of Marília Ahi Evran University
São Paulo, Brazil Faculty of Medicine
Kırşehir, Turkey
Burcu Beksaç
Department of Dermatology Vefa Aslı Turgut Erdemir
Gülhane Research and Training Hospital Department of Dermatology
Ankara, Turkey Istanbul Medeniyet University
Faculty of Medicine
Akif Bilgen Göztepe Training and Research Hospital
Department of Otolaryngology, Head Istanbul, Turkey
and Neck Surgery
Health Science University Sümeyre Seda Ertekin
Ankara Training and Research Hospital Department of Dermatology
Ankara, Turkey Aksaray University
Faculty of Medicine
Piotr Brzezinski Training and Research Hospital
Department of Dermatology Aksaray, Turkey
Institute of Biology and Environmental Protection
Pomeranian Academy Fehim Esen
Slupsk, Poland Department of Ophthalmology
and Istanbul Medeniyet University
6th Military Support Unit Faculty of Medicine
Ustka, Poland Istanbul, Turkey
vii
viii Contributors
Ruta Ganceviciene Ayşegül Sevim Keçici
Departments of Dermatology, Venereology, Department of Dermatology
Allergology, and Immunology University of Medical Sciences
Dessau Medical Center Haydarpaşa Numune Training and Research Hospital
Brandenburg Medical School Theodor Fontane Istanbul, Turkey
Dessau, Germany
Ananta Khurana
Department of Dermatology
Mehmet Salih Gurel
Post Graduate Institute of Medical Education and Research
Department of Dermatology
Dr RML Hospital
Istanbul Medeniyet University
Delhi, India
Faculty of Medicine
Göztepe Training and Research Hospital
André Koch
Istanbul, Turkey
Department of Dermatology and Allergology
Städtisches Klinikum Dresden
Mehmet Ali Gürer
Academic Teaching Hospital of the Technical
Department of Dermatology
University of Dresden
Gazi University
Dresden, Germany
Faculty of Medicine
Ankara, Turkey
Zekayi Kutlubay
Department of Dermatology
Reese L. Imhof Istanbul University
Mayo Clinic School of Medicine Faculty of Medicine
Rochester, Minnesota Cerrahpaşa Faculty of Medicine
Istanbul, Turkey
Filiz Cebeci Kahraman
Department of Dermatology Kaitlyn Lam
Istanbul Medeniyet University MD Program
Faculty of Medicine University of Toronto
Göztepe Training and Research Hospital Faculty of Medicine
Istanbul, Turkey Toronto, Ontario, Canada
Ezgi Aktaş Karabay Catherine M. Ludwig
Department of Dermatology University of Illinois College of Medicine
Bahçeşehir University Chicago, Illinois
Faculty of Medicine
Istanbul, Turkey Bodo C. Melnik
Department of Dermatology, Environmental Medicine
and Health Theory
Ayse Serap Karadag
University of Osnabrück
Department of Dermatology
Osnabrück, Germany
Istanbul Medeniyet University
Faculty of Medicine
Emin Ozlu
Göztepe Training and Research Hospital
Department of Dermatology
Istanbul, Turkey
Düzce University
Faculty of Medicine
Remzi Karadag
Düzce, Turkey
Department of Ophthalmology
Istanbul Medeniyet University
Nadide Burcu Öztürk
Faculty of Medicine
Department of Dermatology
Göztepe Training and Research Hospital
Private Practice
Istanbul, Turkey
Kocaeli, Turkey
Melek Aslan Kayıran Lawrence Charles Parish
Department of Dermatology Department of Dermatology and Cutaneous Biology
Istanbul Medeniyet University Sidney Kimmel Medical College at Thomas Jefferson University
Faculty of Medicine and
Göztepe Training and Research Hospital Jefferson Center for International Dermatology
Istanbul, Turkey Philadelphia, Pennsylvania
Contributors ix
Letícia Maria Pescinini-Salzedas Megha M. Tollefson
School of Medicine Department of Dermatology
Department of Pharmacology Mayo Clinic
University of Marília Rochester, Minnesota
São Paulo, Brazil
Maria M. Tsoukas
Jelena Popovic Department of Dermatology
Laboratory for Human Molecular Genetics University of Illinois College of Medicine
Institute of Molecular Genetics and Genetic Chicago, Illinois
Engineering
Belma Türsen
University of Belgrade
Department of Dermatology
Belgrade, Serbia
Private Practice
Mersin, Turkey
Marius Rademaker
Waikato Clinical School
Ümit Türsen
School of Medicine
Department of Dermatology
University of Auckland
Mersin University
Auckland, New Zealand
Faculty of Medicine
Mersin, Turkey
Brandon Roman
University of Illinois College of Medicine
Yalçın Tüzün
Chicago, Illinois
Department of Dermatology
Medical Park Hospital
Joya Sahu
Istanbul, Turkey
Pathology and Hematology Oncology
Cutaneous Lymphoma Multidisciplinary Center Tugba Kevser Uzuncakmak
Sidney Kimmel Medical College at Thomas Department of Dermatology
Jefferson University Istanbul Medeniyet University
Philadelphia, Pennsylvania Faculty of Medicine
Istanbul, Turkey
Kabir Sardana
Department of Dermatology Ronald Vender
Post Graduate Institute of Medical MD Program
Education and Research University of Toronto
Dr RML Hospital Faculty of Medicine
Delhi, India Toronto, Ontario, Canada
Claire Wilson
Joshua Schimmel
University of Illinois College of Medicine
Cooper Medical School of Rowan University
Chicago, Illinois
Camden, New Jersey
Uwe Wollina
Zehra Aşiran Serdar
Department of Dermatology and Allergology
Department of Dermatology
Städtisches Klinikum Dresden
Bahçeşehir University
Academic Teaching Hospital of the Technical
Faculty of Medicine
University of Dresden
Istanbul, Turkey
Dresden, Germany
Rodney Sinclair Elif Yildirim
Department of Medicine Department of Dermatology
University of Melbourne Sanko University
Epworth Dermatology Faculty of Medicine
Sinclair Dermatology Gaziantep, Turkey
Melbourne, Australia
Christos C. Zouboulis
Asli Tatliparmak Departments of Dermatology, Venereology,
Department of Dermatology Allergology, and Immunology
Bahçeşehir University Dessau Medical Center
Faculty of Medicine Brandenburg Medical School Theodor Fontane
Istanbul, Turkey Dessau, Germany