Table Of ContentAdvances in Experimental Medicine and Biology 944
Neuroscience and Respiration
Mieczyslaw Pokorski Editor
Respiratory
Treatment
and Prevention
Advances in Experimental Medicine
and Biology
Neuroscience and Respiration
Volume 944
Editorial Board
Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel
N.S.AbelLajtha,KlineInstituteforPsychiatricResearch,Orangeburg,NY,USA
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Rodolfo Paoletti, University of Milan, Milan, Italy
Subseries Editor
Mieczyslaw Pokorski
More information about this series at http://www.springer.com/series/13457
Mieczyslaw Pokorski
Editor
Respiratory Treatment
and Prevention
Editor
MieczyslawPokorski
PublicHigherMedicalProfessionalSchoolinOpole
InstituteofNursing
Opole,Poland
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-44487-1 ISBN978-3-319-44488-8 (eBook)
DOI10.1007/978-3-319-44488-8
LibraryofCongressControlNumber:2016958561
#SpringerInternationalPublishingSwitzerland2017
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Preface
The book series Neuroscience and Respiration presents contributions by
expert researchers and clinicians in the field of pulmonary disorders. The
chapters provide timely overviews of contentious issues or recent advances
in the diagnosis, classification, and treatment of the entire range of pulmo-
narydisorders,bothacuteandchronic.Thetextsarethoughtasamergerof
basic and clinical research dealing with respiratory medicine, neural and
chemical regulation of respiration, and the interactive relationship between
respiration and other neurobiological systems such as cardiovascular func-
tionorthemind-to-bodyconnection.Theauthorsfocusontheleading-edge
therapeutic concepts, methodologies, and innovative treatments. Pharmaco-
therapy is always in the focus of respiratory research. The action and
pharmacology of existing drugs and the development and evaluation of
new agents are the heady area of research. Practical, data-driven options to
manage patients will be considered. New research is presented regarding
older drugs, performed from a modern perspective or from a different
pharmacotherapeutic angle. The introduction of new drugs and treatment
approachesinbothadultsandchildrenalsoisdiscussed.
Lung ventilation is ultimately driven by the brain. However, neuropsy-
chologicalaspectsofrespiratorydisordersarestillmostlyamatterofconjec-
ture. After decades of misunderstanding and neglect, emotions have been
rediscovered as a powerful modifier or even the probable cause of various
somatic disorders. Today, the link between stress and respiratory health is
undeniable. Scientists accept a powerful psychological connection that can
directlyaffectourqualityoflifeandhealthspan.Psychologicalapproaches,
bydecreasingstress,canplayamajorroleinthedevelopmentandtherapyof
respiratorydiseases.
Neuromolecular aspects relating to gene polymorphism and epigenesis,
involvingbothheritablechangesinthenucleotidesequenceandfunctionally
relevantchangestothegenomethatdonotinvolveachangeinthenucleotide
sequence, leading to respiratory disorders will also be tackled. Clinical
advancesstemmingfrommolecularandbiochemicalresearcharebutpossi-
ble if the research findings are translated into diagnostic tools, therapeutic
procedures,andeducation,effectivelyreachingphysiciansandpatients.All
thatcannotbeachievedwithoutamultidisciplinary,collaborative,bench-to-
bedsideapproachinvolvingbothresearchersandclinicians.
v
vi Preface
Thesocietalandeconomicburdenofrespiratoryailmentshasbeenonthe
rise worldwide leading to disabilities and shortening of life span. COPD
alone causes more than three million deaths globally each year. Concerted
efforts are required to improve this situation, and part of those efforts are
gaining insights into the underlying mechanisms of disease and staying
abreast with the latest developments in diagnosis and treatment regimens.
Itishopedthatthebookspublishedinthisserieswillassumealeadingrolein
the field of respiratory medicine and research and will become a source of
referenceandinspirationforfutureresearchideas.
I would like to express my deep gratitude to Mr. Martijn Roelandse and
Ms. Tanja Koppejan from Springer’s Life Sciences Department for their
genuineinterestinmakingthisscientificendeavorcomethroughandinthe
expertmanagementoftheproductionofthisnovelbookseries.
Opole,Poland MieczyslawPokorski
Contents
Osteoprotegerin/sRANKLSignalingSysteminPulmonary
Sarcoidosis:ABronchoalveolarLavageStudy. . . . . . . . . . . . . . . . 1
W.Naumnik,B.Naumnik,W.Niklin´ska,M.Ossolin´ska,
andE.Chyczewska
AmbientPM2.5ExposureandMortalityDuetoLungCancer
andCardiopulmonaryDiseasesinPolishCities. . . . . . . . . . . . . . . 9
ArturJ.Badyda,JamesGrellier,andPiotrDa˛browiecki
Non-TuberculousMycobacteria:Classification,Diagnostics,
andTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
I.Porvaznik,I.Solovicˇ,andJ.Mokry´
DiagnosisofInvasivePulmonaryAspergillosis. . . . . . . . . . . . . . . . 27
E.Swoboda-Kopec´,M.Sikora,K.Piskorska,M.Gołas´,
I.Netsvyetayeva,D.Przybyłowska,andE.Mierzwin´ska-Nastalska
RarityofMixedSpeciesMalariawithPlasmodiumfalciparum
andPlasmodiummalariaeinTravelerstoSaarland
inGermany. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
JosefYayanandKurtRasche
AntibioticsModulatetheAbilityofNeutrophilstoRelease
NeutrophilExtracellularTraps. . . . .. . . . . . . . .. . . . . . . . .. . . . . 47
AnetaManda-Handzlik,W.Bystrzycka,S.Sieczkowska,
U.Demkow,andO.Ciepiela
SensitivityofNext-GenerationSequencingMetagenomic
AnalysisforDetectionofRNAandDNAViruses
inCerebrospinalFluid:TheConfoundingEffect
ofBackgroundContamination. . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
IwonaBukowska-Os´ko,KarolPerlejewski,ShotaNakamura,
DaisukeMotooka,TomaszStokowy,JoannaKosin´ska,
MartaPopiel,RafałPłoski,AndrzejHorban,DariuszLipowski,
KamilaCaraballoCorte´s,AgnieszkaPawełczyk,UrszulaDemkow,
AdamSte˛pien´,MarekRadkowski,andTomaszLaskus
vii
viii Contents
MandibularAdvancementApplianceforObstructive
SleepApneaTreatment. . . . . .. . . . . .. . . . . .. . . . . .. . . . . .. . . . 63
J.Kostrzewa-Janicka,P.S´liwin´ski,M.Wojda,D.Rolski,
andE.Mierzwin´ska-Nastalska
AcuteResponsetoCigaretteSmokingAssessedinExhaled
BreathCondensateinPatientswithChronicObstructive
PulmonaryDiseaseandHealthySmokers. . . . . . . . . . . . . . . . . . . . 73
M.Maskey-Warze˛chowska,P.Nejman-Gryz,K.Osinka,P.Lis,
K.Malesa,K.Go´rska,andR.Krenke
CigaretteSmokingandRespiratorySystemDiseases
inAdolescents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
AgnieszkaSaracen
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . 87
AdvsExp.Medicine,Biology-NeuroscienceandRespiration(2016)27:1–7
DOI10.1007/5584_2016_44
#SpringerInternationalPublishingSwitzerland2017
Publishedonline:12July2016
Osteoprotegerin/sRANKL Signaling
System in Pulmonary Sarcoidosis:
A Bronchoalveolar Lavage Study
W. Naumnik, B. Naumnik, W. Niklin´ska, M. Ossolin´ska,
and E. Chyczewska
Abstract
Osteoprotegerin (OPG), a soluble tumor necrosis factor receptor family
molecule,protectsendothelialcellsfromapoptosisinvitroandpromotes
neovascularization in vivo. Angiogenesis may be crucial for the course
and outcome of sarcoidosis. In this study, we evaluated the clinical
usefulness of OPG and its ligand, a soluble receptor activator of nuclear
factor-kappaB (sRANKL), in bronchoalveolar lavage fluid (BALF) in
patients with sarcoidosis (BBS, Besniera-Boeck-Schaumann disease).
We studied 22 BBS patients and 15 healthy volunteers as a control
group. The levels of OPG, sRANKL, and interleukin-18 (IL-18) were
measuredby the Elisa method. TheBALF levels ofsRANKL andIL-18
werehigherintheBBSpatientscomparedwithcontrols[sRANKL:2.12
(0.82–10.23) vs. 1.12 (0.79–4.39) pmol/l, p ¼ 0.03; IL-18: 34.29
(12.50–133.70) vs. 13.05 (12.43–25.88) pg/ml, p ¼ 0.001]. There were
no significant differences between the concentration of OPG in the BBS
patientsandhealthycontrols[0.22(0.14–0.81)vs.0.23(0.14–0.75)pmol/
l].IntheBBSpatientswefoundcorrelationsbetweensRANKLandIL-18
in BALF (r ¼ 0.742, p ¼ 0.0001) and between OPG and lung diffusing
capacity for carbon monoxide (DLCO) (r ¼ (cid:2)0.528, p ¼ 0.029).
Receiver-operating characteristic (ROC) curve was applied to find the
cut-off for the BALF level of sRANKL (BBS vs. healthy: 1.32 pmol/l).
W.Naumnik(*)
FirstDepartmentofLungDiseases,MedicalUniversityof
Bialystok,14ZurawiaSt,15-540Bialystok,Poland
DepartmentofClinicalMolecularBiology,Medical
UniversityofBialystok,Bialystok,Poland W.Niklin´ska
e-mail:[email protected] DepartmentofHistologyandEmbryology,Medical
UniversityofBialystok,Bialystok,Poland
B.Naumnik
FirstDepartmentofNephrologyandTransplantationwith M.Ossolin´skaandE.Chyczewska
DialysisUnit,MedicalUniversityofBialystok,Bialystok, FirstDepartmentofLungDiseases,MedicalUniversityof
Poland Bialystok,14ZurawiaSt,15-540Bialystok,Poland
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