Table Of ContentE.Ueno,T.Shiina,M.Kubota,K.Sawai (Eds.)
Research and Development in Breast Ultrasound
E. Ueno, T. Shiina
M. Kubota, K. Sawai (Eds.)
Research and Development
in Breast Ultrasound
With 150Figures,Including 37in Color
1 3
Ei Ueno,M.D.,Ph.D.
Associate Professor,Department ofBreast-Thyroid-Endocrine Surgery
Institute ofClinical Medicine,University ofTsukuba
1-1-1Tennodai,Tsukuba,Ibaraki 304-8573,Japan
Tsuyoshi Shiina,Ph.D.
Professor,Institute ofInformation Sciences and Electronics,University ofTsukuba
1-1-1Tennodai,Tsukuba,Ibaraki 304-8573,Japan
Mitsuhiro Kubota,M.D.
Director ofYamachika Memorial Hospital
3-19-14Koyawata,Odawara,Kanagawa 256-0815,Japan
Kiyoshi Sawai,M.D.
Associate Professor,Department ofEndocrine & Breast Surgery
Kyoto Prefectural University ofMedicine
465Kajii-cho,Kawaramachi-Hirokoji,Kamigyo-ku,Kyoto 602-0841,Japan
Cover Illustration:Madoka Momota
Library ofCongress Control Number:2004116202
ISBN 4-431-40277-2Springer-Verlag Tokyo Berlin Heidelberg New York
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Preface
Ultrasonic examination ofthe breast has been a valuable diagnostic tool for more than
halfa century since J.J.Wild,T.Wagai,and others first used it in 1950.The first Inter-
national Congress on the Ultrasonic Examination ofthe Breast (ICUEB) was convened
in Philadelphia in 1979by Goldberg (United States),Wells (United Kingdom),Wagai
(Japan),Kobayashi (Japan),and Kossoff(Australia).Further congresses in the series
have taken place every other year to discuss related theoretical and clinical discover-
ies. These meetings led to the founding of the International Association for Breast
Ultrasound (IABU) in 1991,and have contributed to improving ultrasonic examina-
tion techniques and the associated medical benefits.
The 13th ICUEB was held in Kyoto,Japan,in April 2003.International events at that
time—the military operations in Iraq and the SARS outbreaks in several countries—
threatened attendance;however,only one oral presentation and one poster presenta-
tion had to be canceled,and an impressive 98% ofour schedule proceeded as planned.
Over the three days of the congress, participants made significant contributions
through presentations and discussions, and we moved closer to a global mutual
understanding.
From the many oral presentations and posters we selected the best for publication
in this volume,entitled Research and Development in Breast Ultrasound. The book
covers a variety ofengaging topics,including discovery ofthe piezoelectric phenom-
enon,DCIS diagnosis,interventional ultrasound,screening by ultrasound,and diag-
nostic criteria.It also includes an original paper by Dr.Kujiraoka,“Incident Angle of
the Plunging Artery ofBreast Tumors,”which won first prize at the poster session.We
are sure the next ICUEB will build on these strong foundations.
Finally,special heartfelt thanks go to Professor Ki Keun Oh from Korea,Dr.Yi-Hong
Chou from Taiwan,and Dr.Jack Jellins from IBAS.
Ei Ueno,M.D.
Chairman,13th ICUEB
ChiefEditor
V
Contributors
The following organizations and individuals provided financial support for the 13th
International Congress on the Ultrasonic Examination ofthe Breast (ICUEB).
Public Organizations:
Commemorative Organization for the Japan World Exposition ’70
Japan National Tourist Organization
The Pharmaceutical Manufacturers Association ofTokyo
Oosaka Pharmaceutical Manufacturers Association
The Japan Labor Cultural Association
Ibaraki Health Service Association
Pharmaceutial Companies:
Amgen Ltd. Kakenshoyaku Co.,Ltd.
Asahi Chemical Industry Co.,Ltd. Kanebo,Ltd.
AstraZeneca Kirin Brewery Co.,Ltd.
Aventis Pharma Ltd. Kissei Pharmaceutical Co.,Ltd.
Azwell Inc. Kowa Company,Ltd.
Banyu Pharmaceutical Co.,Ltd. Kyorin Pharmaceutical Co.,Ltd.
Bayer AG Kyowa Hakko Kogyo Co.,Ltd.
Bristol Myers K.K. Maruho Co.,Ltd.
Chugai Pharmaceutical Co.,Ltd. Maruishi Pharmaceutical Co.,Ltd.
Daiichi Pharmaceutical Co.,Ltd. Meiji Milk Products Co.,Ltd.
Dainippon Pharmaceutical Co.,Ltd. Meiji Seika Kaisha Ltd.
Eiken Chemical Co.,Ltd. Merck Hoei Ltd.
Eisai Co.,Ltd. Mikasa Seiyaku Co.,Ltd.
Elmed Eisai Co.,Ltd. Minophagen Pharmaceutical Co.,Ltd.
Fujisawa Pharmaceutical Co.,Ltd. Mitsubishi Pharma Corporation
Fuso Pharmaceutical Industries,Ltd. Mochida Pharmaceutical Co.,Ltd.
Graxo Smith Kline K.K. Morinaga Milk Industry Co.,Ltd.
Grelan Pharmaceutical Co.,Ltd. Nihon Pharmaceutical Co.,Ltd.
Japan Tobacco Inc. Nihon Schering K.K.
Kaken Pharmaceutical Co.,Ltd. Nikken Chemicals Co.,Ltd.
VII
VIII Contributors
Nippon Boehringer Ingelheim Co.,Ltd. SSP Co.,Ltd.
Nippon Chemiphar Co.,Ltd. Sumitomo Pharmaceutical Co.,Ltd.
Nippon Kayaku Co.,Ltd. Taiho Pharmaceutical Co.,Ltd.
Nippon Shinyaku Co.,Ltd. Taisho Pharmaceutical Co.,Ltd.
Nippon Zoki Pharmaceutical Co.,Ltd. Takeda Chemical Industries,Ltd.
Nipro Pharma Corporation Tanabe Seiyaku Co.,Ltd.
Novartis Pharma K.K. Teijin Ltd.
Ono Pharmaceutical Co.,Ltd. Teikoku Hormone Mfg.Co.,Ltd.
Otsuka Pharmaceutical Co.,Ltd. Terumo Corporation,Japan
Pfizer Japan Inc. Toa Eiyo Ltd.
Rohto Pharmaceutical Co.,Ltd. Torii Pharmaceutical Co.,Ltd.
Sankyo Co.,Ltd. Towa Pharmaceutical Co.,Ltd.
Santen Pharmaceutical Co.,Ltd. Toyama Chemical Co.,Ltd.
Sanwa Kagaku Kenkyusho Co.,Ltd. Tsumura & Co.
Sato Pharmaceutical Co.,Ltd. Wakamoto Pharmaceutical Co.,Ltd.
Sawai Pharmaceutical Co.,Ltd. Wyeth Lederle Japan,Ltd.
Schering-Plough K.K. Yakult Co.,Ltd.
Shionogi & Co.,Ltd. Yamanouchi Pharmaceutical Co.,Ltd.
Snow Brand Milk Products Co.,Ltd.
Others:
Mr.Hiroaki Aoki Miyamae Clinic
Asazen Ms.Itsuko Ogura
Breast Clinic Kodama Surgery Ohtashiro Clinic
Chikatsu Clinic Dr.Noriko Ohtashiro
Hayashi Clinic Ryuin-kai Ushio Hospital
Ibarakiken Medical Center Saitoh Clinic
Ide Clinic Suzuki ENT Clinic
Mr.Seiji Inagawa Takezono Skin Clinic
Mr.Mikio Kakinuma Ms.Utako Tayama
Kogure Clinic Ms.Fumi Tsuritani
Kokonomi-kai Shimazaki Clinic Ueno Surgical Clinic
Ms.Tomiko Kuriyama Mr.Haruyuki Yamada
Medison Co.,Ltd. Zensen-kai
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VII
Discovery ofthe Piezoelectric Phenomenon:Curie and Langevin
D.Amy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
A Review ofTheoretical and Experimental Aspects ofImaging the
Elastic Attributes ofTissue In Vivo
J.Ophir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
In Vivo Breast Examination by Real-Time Freehand Elasticity
Imaging System
T.Shiinaand E.Ueno . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Usefulness ofUltrasonic Strain Measurement-Based Mechanical
Properties Imaging Technique:Toward Realization ofShort-Time
Diagnosis/Treatment
C.Sumi,M.Kubota,G.Wakabayashi,and M.Tanabe . . . . . . . . . . . . . . 16
Mass Detection Using a Texture Feature Coding Method
P.-S.Liao,S.-M.Guo,Y.-C.Liao,S.-C.Yang,C.-W.Yang,H.-M.Chen,
P.-C.Chung,S.K.Lee,and C.-I.Chang . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
Breast Tissue Assessments Based on High Order Mechanical Properties
N.Nittaand T.Shiina . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
Forms ofTumors
T.Watanabe,E.Ueno,T.Endo,M.Kubota,Y.Konishi,H.Sakuma,
K.Shimamoto,H.Tsunoda-Shimizu,H.Hashimoto,N.Masuda,
M.Mizutani,I.Morishima,and H.Yasuda . . . . . . . . . . . . . . . . . . . . . . . 55
Usefulness ofDepth to Width Ratio in Differentiation ofRegular Invasive
Ductal Carcinoma from Fibroadenoma
H.Tsunoda-Shimizu,Y.Kato,E.Ueno,T.Endo,M.Shirouzu,
R.Watanabe,H.Hashimoto,Y.Ogawa,T.Takashima,Y.Fujimoto,
H.Shirai,M.Nagae,N.Unuma,N.Masuda,N.Obane,I.Morishima,
Y.Kujiraoka,K.Omoto,and N.Taniguchi . . . . . . . . . . . . . . . . . . . . . . . 57
IX
X Contents
Margin,Border,and Boundary Zone ofBreast Tumor Ultrasonography
H.Yasuda,E.Ueno,T.Endo,M.Kubota,Y.Konishi,H.Sakuma,
K.Shimamoto,H.Tsunoda-Shimizu,I.Morishima,and
T.Watanabe . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62
Revised Diagnostic Criteria for the Breast (Draft):Internal Echoes
M.Kubota,Y.Konishi,K.Shimamoto,K.Tanaka,H.Tsunoda-Shimizu,
H.Hashimoto,N.Masuda,M.Mizutani,I.Morishima,H.Yasuda,
T.Watanabe,E.Ueno,and T.Endo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66
Incident Angle ofthe Plunging Artery ofBreast Tumors
Y.Kujiraoka,E.Ueno,E.Tohno,I.Morishima,and
H.Tsunoda-Shimizu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72
Draft JSUM Diagnostic Guidelines for Mass Image-Forming Lesions
E.Ueno,T.Endo,M.Kubota,A.Kawauchi,Y.Kato,Y.Konishi,
M.Mizutani,E.Tohno,H.Tsunoda-Shimizu,N.Taniguchi,
H.Yasuda,T.Watanabe,K.Shimamoto,H.Hashimoto,N.Masuda,
and I.Morishima . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76
Draft Diagnostic Guidelines for Non-Mass Image-Forming Lesions by the
Japan Association ofBreast and Thyroid Sonology (JABTS) and the Japan
Society ofUltrasonics in Medicine
T.Endo,M.Kubota,Y.Konishi,K.Shimamoto,K.Tanaka,
H.Tsunoda-Shimizu,H.Hashimoto,N.Masuda,M.Mizutani,
I.Morishima,H.Yasuda,T.Watanabe,and E.Ueno . . . . . . . . . . . . . . . 89
JABTS Breast Ultrasound Training Course:Program and Results
E.Tohno,K.Sawai,and theMembersoftheEducation
CommitteeofJABTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101
Ductal Carcinoma In Situ ofthe Breast:The Pathological Reason for
the Diversity ofIts Clinical Imaging
S.Ichihara,S.Moritani,T.Ohtake,and N.Ohuchi . . . . . . . . . . . . . . . 104
Ductal Carcinoma In Situ (DCIS):Incidence,Prognosis,and Diagnostic
Aspects ofMammography,Galactography,and Needle Biopsies
G.Svane . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114
The Ultrasonic Diagnosis ofNonpalpable DCIS Without Calcification on
MMG and Nipple Discharge:Advocacy ofa New Term,3Non-DCIS
K.Takebeand A.Izumori . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Ultrasonic Diagnosis ofNon-Mass Image-Forming Breast Cancer
I.Morishima,E.Ueno,E.Tohno,H.Tsunoda-Shimizu,
Y.Kujiraoka,and M.Takasaki . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Characteristic Mammography and Ultrasonography Findings ofDuctal
Carcinoma In Situ ofthe Breast Arising in Sclerosing Adenosis
K.Tanaka,H.Sakuma,G.Sakamoto,F.Akiyama,and F.Kasumi . . . . . 135
Contents XI
Preoperative Ultrasonic Assessment for Breast-Conserving Treatment
T.Kudo,Y.Kiyosawa,I.Ono,and M.Kubota . . . . . . . . . . . . . . . . . . . . . . 141
Recent Advances in Multidimensional 3D/4D Breast Imaging
C.Weismann . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146
3D Ultrasound-Based Evaluation ofLesions in the Uncompressed Breast
C.Riis,A.Lernevall,F.B.Sorensen,and H.Nygaard . . . . . . . . . . . . . . 151
The Role ofUltrasound in Population-Based Breast Cancer
Screening Programs
E.Azavedo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156
Breast Cancer Screening by Palpation,Ultrasound,and Mammography
H.Morikubo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159
A Review ofBreast Cancer Undetectable by Ultrasonography in a
Screening Setting
M.Yamasaki,S.Nasu,H.Mori,S.Koga,and S.Koga . . . . . . . . . . . . . . 163
Ultrasonic Screening ofthe Thyroid in Patients with Breast Complaints
Y.Fujimoto,M.Hatama,K.Tezuka,H.Otani,Y.Arimoto,
K.Ikeda,S.Shimizu,Y.Ogawa,and Y.Nishiguchi . . . . . . . . . . . . . . . . . 167
Phantom and Human Experiments for Breast Cancer Detection by
Ultrasound Transmission Technique
Y.Hayakawa,A.Sakasegawa,and K.Tsuji . . . . . . . . . . . . . . . . . . . . . . . 170
Breast Cancer Ablation:Imaging and Early Experience
H.I.Vargas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 176
US-Guided Mammotome Biopsy ofBreast Masses in Comparison with
US-Guided Aspiration Biopsy Cytology
N.Tohnosu,Y.Kobayashi,T.Natsume,T.Kato,and T.Uehara . . . . . . 181
Ultrasonographic Appearance and Clinical Implication ofBilateral
Breast Infiltration with Leukemia Cells
S.Asai,H.Miyachi,M.Kubota,N.Koyanagi,Y.Ogawa,T.Hotta,
and Y.Ando . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Analysis ofUltrasonographic Findings ofBreast Masses by the Nagasawa
Computer-Aided Diagnosis System
S.Kaoku,Y.Kato,T.Takashima,Y.Ogawa,Y.Fujimoto,
T.Nagasawa,and K.Hirakawa . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190
Dorsal Growth ofBreast Cancer May Correlate with the Prognosis
H.Yoshibayashi,S.Nishimura,and S.Matusue . . . . . . . . . . . . . . . . . . . 196
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
