Table Of ContentRegulation of
78rget Cell
Responsiveness
Volume 1
BIOCHEMICAL ENDOCRINOLOGY
Series Editor: Kenneth W. McKerns
STRUCTURE AND FUNCTION OF THE GONADOTROPINS
Edited by Kenneth W. McKerns
SYNTHESIS AND RELEASE OF ADENOHYPOPHYSEAL
HORMONES
Edited by Marian J utisz and Kenneth W. McKerns
REPRODUCTIVE PROCESSES AND CONTRACEPTION
Edited by Kenneth W. McKerns
HORMONALLY ACTIVE BRAIN PEPTIDES: Structure and Function
Edited by Kenneth W. McKerns and Vladimir Pantie
REGULATION OF GENE EXPRESSION BY HORMONES
Edited by Kenneth W. McKerns
REGULATION OF TARGET CELL RESPONSIVENESS, Volumes 1 and 2
Edited by Kenneth W. McKerns, Asbjll.lrn Aakvaag, and Vi dar Hansson
Regulation of
Target Cell
Responsiveness
Volume 1
Edited by
Kenneth W McKerns
International Foundation for Biochemical Endocrinology
Blue Hill Falls, Maine
Asbj¢rn Aakvaag
Aker Hospital
Oslo, Norway
and
Vidar Hansson
Institute of Pathology
Oslo, Norway
PLENUM PRESS •
NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
Main entry under title:
Regulation of target cell responsiveness.
(Biochemical endocrinology)
Proceedings from the tenth meeting of the International Foundation for Biochemical
Endocrinology, held in Geilo, Norway in Sept. 1982.
Bibliography: p.
Includes index.
1. Hormones-Physiological effect-Congresses. 2. Cellular control mechanisms
Congresses. 3. Hormone receptors-Congresses.l. McKerns, Kenneth W. II. Aakvaag,
Asbj<irn. Ill. Hansson, Vidar. IV. International Foundation for Biochemical En
docrinology. V. Series. [DNLM: 1. Hormones-Physiology-Congresses. 2. Peptides
-Physiology-Congresses. WK 102 R3437 1982]
QP187.3.C44R44 1984 599'.0142 83-24773
ISBN 978-1-4684-4636-4 ISBN 978-1-4684-4634-0 ( eBook)
DOl 10.1007I 978-1-4684-4634-0
© 1984 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1984
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Preface
The tenth meeting of the International Foundation for
Biochemical Endocrinology was held in Geilo, Norway near the
end of September, 1982. The subject matter of the conference
and the monograph was on "Regulation of Target Cell Respon
siveness." The local organizing committee was Asbjjllrn Aakvaag
and Vidar Hansson.
The scientific sessions covered a wide range of hormone
action and cell response, including: peptide hormones and
target cell response, regulation of insulin responsiveness,
intracellular modulation of peptide hormone response, gonado
tropins and target cell responses, hypothalamic hormones -
effects and regulation, steroid receptors and cellular
control, hormones and growth regulation, and hormones and
gene regulation. The chairpersons for the sessions were L.
Birnbauer -A. Aakvaag, S. Taylor- R. S. Horn, F. Labrie- F.
Rommerts, A. R. Means - K. W. McKerns, P. F. Hall - V. Hansson
K. Griffiths - K. M. Gautvik, E. J. Peck, Jr. -E. Haug, F. S.
French- W. T. Schrader, and E. M. Ritzen- B. Jegou.
In addition to the scientific sessions in Geilo we were
all delighted to sample some of the cultural and artistic
attractions of Oslo, and to travel by train from Oslo via
Geilo to Bergen. The scenery and hospitality were magnifi
cant.
The Foundation thanks the many people who assisted at
the meeting and in the preparation of the monograph. These
include Mrs. Kjersti Gunneng who served as general secretary
for the organization in Norway; Mrs. James Gilmore who acted
as secretary for the Foundation in Maine and who assisted in
the preparation of the index. Mrs. Francine Hood was in
charge of the monumental job of retyping all of the manu
scripts into the memory bank of a computer for the preparation
of photo-ready copy. Mrs. Valerie McCadden acted as adviser
to this preparation.
v
vi PREFACE
The 1983 meeting and monograph of the Foundation will be
held in early October in Rehovot, Israel. This will deal
broadly with the topic, "Hormonal Control of Hypothalamo
Pituitary-Gonadal Axis." The local organ1z1ng committee
consists of Zvi Naor, Chairman, Nava Dekel, Yitzhak Koch,
Fortune Kohen and Uriel Zor.
Kenneth W. McKerns
Blue Hill Falls, Maine
Acknowledgments
The following public organizations and private contribu
tors have given financial assistance to support this colloque.
The organizing committee and the Foundation members aregrate
ful for this generous support:
Norwegian Agency for International Development (NORAD)
Norwegian Medical Research Council (NAVF)
Norwegian Society for Fighting Cancer
The Norwegian Cancer Society
The Royal Norwegian Ministry of Culture and Science
Bergman Instrumentering A/S
Heigar & Co. A/S
F. Hoffman - La Roche & Co. AG
Nyegaard & Co. A/S (NYCO)
Organon International bv
Ria-Data A/S
Schering AG, Berlin
vii
Contents of Volume 1
Peptide Hormones and Target Cell Response
Chapter 1. Regulation of Sertoli Cell Responsiveness:
Desensitization of Adenylyl Cyclase by FSH,
Isoproterenol and Glucagon........................ 3
H. Attramadal, T. Jahnsen, F. Le Gac, and
V. Hansson
Chapter 2. Stage-Dependent Differences in FSH Binding
and Cyclic Nucleotide Secretion and Metabolism
During the Cycle of the Rat Seminiferous
Tubule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
K. Purvis, M. Parvinen, K. Gautvik, and
V. Hansson
Chapter 3. Development of Sensitivity to Catechola-
mines in Granulosa and Luteal Cells ............... 37
Gunnar Selstam, Sheela Rani, Knut Nordenstrom,
Ensio Norjavaara, Sten Rosberg, and Kurt Ahren
Chapter 4. Effects of Prostaglandin F2 on Adenylyl
Cyclase Activity and Steroid Secrgtion in the
Superlutenized Rat Ovary .......................... 55
P. A. Torjesen and A. Aakvaag
Chapter 5. Electrophosiological Aspects of the
Response of Pituitary Cells to Steroid and
Peptide Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
B. Dufy, L. Dufy-Barbe, E. Zyzek, Jean-Marc
Israel and Jean-Didier Vincent
ix
X CONTENTSOFVOLUME1
Chapter 6. Hormonal Regulation of Adenylyl Cyclase
Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
H. J. Kirchick, J. Codina, J. D. Hildebrant,
R. Iyengar, F. J. Rojas, J. Abramowitz,
M. Hunzicker-Dunn, and L. Birnbaumer
Regulation of Insulin Responsiveness
Chapter 7. Receptor Defects in Genetic Forms of
Extreme Insulin Resistance ........................ 133
S. I. Taylor
Chapter 8. The Role of Protein Phosphorylation in
Insulin Action .................................... 161
R. S. Horn and 0. Walaas
Chapter 9. Insulin Regulation of Nuclear Envelope
Functions: Relationship to mRNA Metabolism 183
I. D. Goldfine, F. Purrello and R. Vigneri
Intracellular Modulation of Peptide Hormone Response
Chapter 10. The Role of the Cytoskeleton in the
Responses of Target Cells to Hormones ............. 205
P. F. Hall
Chapter 11. Calmodulin - A Receptor for Calcium
Modulating Hormone Responsivity ................... 231
A. R. Means and J. G. Chafouleas
Chapter 12. Functional Communication between the
Sertoli and Leydig Cells .......................... 267
R. M. Sharpe and F. F. G. Rommerts
Gonadotropins and Target Cell Response
Chapter 13. Regulation of Steroidogenesis in Isolated
Leydig Cells ...................................... 293
F. F. G. Rommerts, G. H. Bakker, R. Molenaar
and H. J. van der Molen
CONTENTS OF VOLUME 1 XI
Chapter 14. Peptide Inhibitors of Intracellular
Gonadotropin Action ............................... 317
K. W. McKerns
Chapter 15. Role of Trophic Hormones in Regulation of
Growth and Function of Responsive Cells ........... 329
A. Jagannadha Rao, J. A. Long, B. D. Gondos,
J. G. Lehoux, and J. Ramachandran
Chapter 16. Utilization of Lipoprotein-Carried
Cholesterol for Steroidogenesis by Rat Luteal
Tissue ............................................ 361
J. F. Strauss, III, L. G. Paavola, M. F. Rosenblum,
T. Tanaka, and J. T. Gwynne
Chapter 17. A Model System for Studying the Effects
of Hormones on Lysosomal Polyphosphoinositide
Metabolism .......................................• 391
M. A. Seyfred, C. A. Collins, and W. W. Wells
Chapter 18. Hollow Fibers: Their Applications to the
Study of Mammalian Cell Function .................. 407
W. C. Hymer, M. Angeline, M. Chu, R. Grindleland,
J. Harkness, J. Hatfield, E. Hibbard, K. Kovacs,
G. Mansur, A. Mastro, K. Motter, J. Parsons,
C. Phelps, B. Ruskin, A. Signorella, W.
Taylor, M. Thorner, G. Tindall, D. Wilbur
Chapter 19. Regulation of Granuloa Cell Responsiveness
to Gonadotropins: Actions of Epidermal and
·Platelet-Derived Growth Factors ..................• 463
J. S. Mondschein and D. W. Schomberg
Chapter 20. Regulation of Gonadotropin Receptors and
Steroidogenic Responses in Cultured Leydig
Tumor Cells ....................................... 487
M. Ascoli and D. A. Freeman
INDEX ••••••••••••••••••••••••••••••••••••••••••••••••••• 525
