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About Redox Biology: Calina Betlazar, Ryan J. Middleton, Richard B. Banati, Guo-Jun Liu
This review article discusses the impact of high and low doses of ionizing radiation on the central nervous system (CNS). Exposure to high doses leads to neuroinflammation and tissue damage through the release of inflammatory molecules by microglia, the innate immune cells of the brain. In contrast, low doses may reduce vulnerability to further radiation through stimulating protective responses like antioxidant defenses. The disparate responses likely reflect different activation states of microglia. The protein TSPO is explored as a potential biomarker for radiation effects, as its expression changes with neuroinflammation and microglial activation states are involved in CNS responses to radiation exposure.
Detailed Information
Author: | ['Tatis Montañez'] |
---|---|
Publication Year: | 2019 |
Pages: | 13 |
Language: | English |
Format: | |
Price: | FREE |
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