Recurrent Implantation Failure

221 Pages·2018·4.915 MB·English

by  Jason M. Franasiak, Richard T. Scott Jr.

Recurrent
Implantation
Failure
Etiologies and Clinical
Management
Jason M. Franasiak
Richard T. Scott Jr.
Editors
123
Recurrent Implantation Failure
Jason M. Franasiak • Richard T. Scott Jr.
Editors
Recurrent Implantation
Failure
Etiologies and Clinical Management
Editors
Jason M. Franasiak Richard T. Scott Jr.
Reproductive Medicine Associates of NJ Reproductive Medicine Associates of NJ
Thomas Jefferson University Thomas Jefferson University
Basking Ridge, NJ Basking Ridge, NJ
USA USA
ISBN 978-3-319-71966-5 ISBN 978-3-319-71967-2 (eBook)
https://doi.org/10.1007/978-3-319-71967-2
Library of Congress Control Number: 2018930026
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To my wife, Kaitlin, who is my constant.
Without your love and support, this book
would not have been possible.
Jason M. Franasiak
Preface
We are fortunate to practice reproductive medicine during a time of unprecedented
success when it comes to assisted reproductive technology. With the advent of com-
prehensive chromosomal screening, the contribution of aneuploidy to implantation
failure has been all but eliminated. Still, though, euploid embryos fail to implant.
Why is that? The dwindling rate of implantation failure makes the remaining cases
a particular challenge for both practitioners and their patients. The very workup for
recurrent implantation failure, let alone available treatment options, often remains
elusive.
This text is unique in its multifaceted approach to thinking about these challeng-
ing cases. It starts with a foundational look at the signaling between the embryo and
endometrium, which leads to the management of embryo and endometrial syn-
chrony. The pathologic nature of implantation failure is then explored with an eye
toward the gamete and embryo to the maternal anatomy, immune, and hematologic
system. The neuroendocrine system is considered as well as the psychological
impact recurrent implantation failure has on patients. Novel theories such as the
female reproductive tract microbiome are also discussed. The text is designed for
clinicians and researchers in the field of reproductive endocrinology and infertility
patients as a guide not only for clinical care but also for encouraging much needed
research in the area.
We live in an exciting time in reproductive medicine. With ever improving
technology that is becoming both widely available and cost-effective, there are
more tools than ever at our fingertips to address the most challenging problems that
confront our patients. It is incumbent upon practitioners and researchers alike to
understand the capabilities and impact of various treatments, both proven and
experimental, for implantation failure. We hope this book offers some answers as
well as raises unaddressed questions as we strive to better our patient care.
Basking Ridge, NJ, USA Jason M. Franasiak, MD, HCLD
Basking Ridge, NJ, USA Richard T. Scott Jr., MD, HCLD
vii
Contents
1 Signaling Between Embryo and Endometrium:
Normal Implantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Chelsea Fox and Bruce A. Lessey
2 Embryo and Endometrial Synchrony in Implantation Failure . . . . . 21
Jason M. Franasiak and Richard T. Scott
3 Spermatogenesis: Fertile Ground for Contributing
to Recurrent Implantation Failure? . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Sorena Keihani, Jeremy B. Myers, and James M. Hotaling
4 Embryonic Factors Associated with Recurrent
Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Daniel J. Kaser and Catherine Racowsky
5 The Genetics of Pregnancy Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Eric J. Forman, Nathan Treff, and Rebekah S. Zimmerman
6 Immune Factors in Recurrent Implantation Failure . . . . . . . . . . . . . . 93
Diana Alecsandru and Juan A. Garcia-Velasco
7 Stress and Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny,
Jie Yu, Shannon D. Whirledge, Alexandra Wilson,
J. David Wininger, Yimin Shu, Robert N. Taylor,
and Sarah L. Berga
8 Hematologic Disease in Implantation Failure . . . . . . . . . . . . . . . . . . . 125
Shelby A. Neal, Jason M. Franasiak, and Richard T. Scott
9 Endocrine Causes of Implantation Failure . . . . . . . . . . . . . . . . . . . . . . 135
Scott Morin, Baris Ata, and Emre Seli
ix
x Contents
10 Anatomic Abnormalities and Recurrent Implantation Failure . . . . . 153
Jeffrey M. Goldberg, Julian Gingold, and Natalia Llarena
11 Microbiome in Embryonic Implantation
and Implantation Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
Jason M. Franasiak, Inmaculada Moreno,
and Carlos Simon
12 Psychosocial Implications of Recurrent Implantation Failure . . . . . . 197
Andrea Mechanick Braverman and Keren Sofer
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Contributors
Diana Alecsandru, MD, PhD Rey Juan Carlos University, IVI RMA-Madrid,
Madrid, Spain
Baris Ata, MD Department of Obstetrics and Gynecology, Koc University School
of Medicine, Istanbul, Turkey
Sarah L. Berga, MD Department of Obstetrics and Gynecology, Wake Forest
School of Medicine, Winston-Salem, NC, USA
Andrea  Mechanick  Braverman, PhD Sidney Kimmel Medical College of
Thomas Jefferson University, Philadelphia, PA, USA
J. David Wininger, PhD Department of Obstetrics and Gynecology, Wake Forest
School of Medicine, Winston-Salem, NC, USA
Jeffrey L. Deaton, MD Department of Obstetrics and Gynecology, Wake Forest
School of Medicine, Winston-Salem, NC, USA
Eric  J.  Forman, MD, HCLD Reproductive Endocrinology and Infertility,
Columbia University, New York, NY, USA
Chelsea Fox, MD Department of Obstetrics and Gynecology, Greenville Health
System, Greenville, SC, USA
Jason M. Franasiak, MD, HCLD Sidney Kimmel Medical College, Thomas
Jefferson University Philadelphia, PA, USA
IVI-RMA of New Jersey, Basking Ridge, NJ, USA
Juan A. Garcia-Velasco, MD, PhD Rey Juan Carlos University, IVI RMA-
Madrid, Madrid, Spain
Julian Gingold, MD Department of Gynecology and Obstetrics, Cleveland Clinic,
Cleveland, OH, USA
xi
xii Contributors
Jeffrey M. Goldberg, MD Department of Gynecology and Obstetrics, Cleveland
Clinic, Cleveland, OH, USA
James M. Hotaling, MD, MS, FECSM Center for Reconstructive Urology and
Men’s Health, Division of Urology, University of Utah, Salt Lake City, UT, USA
Erika Johnston-MacAnanny, MD Department of Obstetrics and Gynecology,
Wake Forest School of Medicine, Winston-Salem, NC, USA
Daniel  J.  Kaser, MD Sidney Kimmel Medical College, Thomas Jefferson
University Philadelphia, PA, USA
IVI-RMA of New Jersey, Basking Ridge, NJ, USA
Sorena Keihani, MD Center for Reconstructive Urology and Men’s Health,
Division of Urology, University of Utah, Salt Lake City, UT, USA
Bruce A. Lessey, MD, PhD Department of Obstetrics and Gynecology, Greenville
Health System, Greenville, SC, USA
Natalia  Llarena, MD Department of Gynecology and Obstetrics, Cleveland
Clinic, Cleveland, OH, USA
Inmaculada Moreno, PhD Research Department, Igenomix, Valencia, Spain
Department of Obstetrics and Gynecology, School of Medicine, Stanford University,
Stanford, CA, USA
Scott Morin, MD Sidney Kimmel Medical College, Thomas Jefferson University
Philadelphia, Philadelphia, PA, USA
IVI-RMA of New Jersey, Basking Ridge, NJ, USA
Jeremy B. Myers, MD, FACS Center for Reconstructive Urology and Men’s
Health, Division of Urology, University of Utah, Salt Lake City, UT, USA
Shelby  A.  Neal, MD Sidney Kimmel Medical College, Thomas Jefferson
University Philadelphia, PA, USA
IVI-RMA of New Jersey, Basking Ridge, NJ, USA
Bonnie Patel, MD Department of Obstetrics and Gynecology, Wake Forest School
of Medicine, Winston-Salem, NC, USA
Catherine Racowsky, PhD, HCLD Department of Obstetrics and Gynecology,
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Richard T. Scott, MD, HCLD Sidney Kimmel Medical College, Thomas Jefferson
University Philadelphia, PA, USA
IVI-RMA of New Jersey, Basking Ridge, NJ, USA