Table Of ContentWENNER-GREN CENTER
INTERNATIONAL SYMPOSIUM SERIES
VOLUME 48
RECEPTOR-RECEPTOR INTERACTIONS
A NEW INTRAMEMBRANE INTEGRATIVE MECHANISM
RECEPTOR-RECEPTOR INTERACTIONS
A NEW INTRAMEMBRANE INTEGRATIVE MECHANISM
Proceedings of an International Symposium held at
The Wenner-Gren Center, Stockholm, October 9th- 11th, 1986
Edited by
Kjell Fuxe
Department of Histology
Karolinska I nstitutet
Stockholm, Sweden
and
Luigi F. Agnati
Department of Human Physiology
University of Modena
Modena, Italy
M
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© The Wenner-Gren Center 1987
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First published 1987
Published in Great Britain by
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Companies and representatives
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British Library Cataloguing in Publication Data
Receptor-receptor interactions : a new
intramembrane integrative mechanism :
proceedings of an International symposium
held at the Wenner-Gren Center, Stockholm,
October 9-11, 1986.-(Wenner-Gren Center
international symposium series; v. 48).
1. Cell receptors 2. Membranes (Biology)
I. Fuxe, Kjell II. Agnati, Luigi F.
III. Series
574.87'5 QM603.C43
ISBN 978-1-349-08951-2 ISBN 978-1-349-08949-9 (eBook)
DOI 10.1007/978-1-349-08949-9
Contents
The Participants X
Opening Address xiv
Session I
Effects of Messengers on Membrane Receptors
PART A Effects of Transmitters and Modulators
Chairman: T. Hokfelt 2
1. Interactions between Convergent Afferent Transmitter Systems
F.E. Bloom,]. Morrison, E. Battenberg,D. LewisandM. Campbell 3
2. Interactions ofPeptides and Monoamines in Central Neurons:
RoleofSecondMessengers G.R. Siggins,A. Ferron,]. Mancillas,
S. ModambaandF.E. Bloom 13
3. Multiple Transduction Mechanisms for Dopamine D2 Receptors in
Anterior Pituitary Cells M. Memo, C. MissaleandP.F. Spano 23
4. Receptor Reserves at aradrenergic and Dopaminergic Autoreceptors
M. Goldstein, E. Meller and C .H. Adler 36
PARTB Effects of Trophic Factors and Gangliosides
Chairman: L. Olson 43
S. Potentiation ofNGF-mediated Effects ofLaminin A. Acheson and
H. Thoenen 44
6. Gangliosides as Modulators ofNeuronotrophic Interactions
G. Toffano, R. Dal Toso, L. Facci, G. Ferrari, D. Benvegnu,
A. Consolazione, M. F avaron and A. Leon 54
7. Influence of Gangliosides and Nerve Growth Factor on the Plasticity
of Forebrain Cholinergic Neurons A.C. Cuello, D. Maysinger,
L. Garofalo,P. Tagari,P.H. Stephens, E. PioroandM. Piotte 62
8. Hippocampal Stimulation of Cholinergic Expression in Primary
Cultures of Basal Forebrain Neurons B.C. WiseandM.B. Emerit 78
'lJ
vi CONTENTS
PARTC Effects ofNe4fosteroids and Classical Steroids
Chairman: J .-A. Gustafsson 88
9. Neurosteroids: Pregnenolone and Dehydroepiandrosterone in the
Brain E.-E. Baulieu, P. Robel, 0. Vatier, M. Haug, C. Le Goascogne
andE. Bourreau 89
10. Estrogenic and Antiestrogenic Modulation of Neuronal Membrane
Sensitivity R.L. Moss, C.A. Dudley, Y.-I. KimandM. Eaton lOS
11. Effects of Estrogens on the Electrophysiological Properties of
Neurons and Adenohypophyseal Cells: Interactions with Dopamine
J.D. Vincent,]. Demotes-Mainard, E. Arnauld and].M. Israel 119
Session II
Interactions between Receptors in the Membrane
PART A Possible Interactions between Molecular and Supramolecular
Entities in the Membrane
Chairman: J. Axelrod 132
12. Receptor Modification and Receptor Disposition in Membranes
D. Cooney, A. Holzhiifer, F. Boege, C. Dees, R. Jurss, A.K. Keenan,
M. H ekman and E .J .M. H elmreich 133
13. Membrane Phospholipid Metabolism and Transmitters M .J. Berridge 145
14. Allosteric Sites and Conformational Transitions of the Acetylcholine
Receptor: Models for Short-term Regulation of Receptor Response
J.P. Changeux,J. Giraudat, M. Dennis, M. Goeldner, C. Hirth, C. Mulle,
F. Revah, A. Devillers-Thiery and T. Heidmann 162
15. Chloride Channel Modulation at GABAergic Synapses in Primary
Cultures of Cortical Neurons S. Vicini, J .M. M ienville and E. Costa 191
16. Mechanisms of Receptor-coupled Signal Transduction R.A. Cerione 200
17. The Gi-protein as a Target ;"or Receptor-Receptor Interactions
K.H. Jakobs, P. Gierschik, R. Grandt and R. Marquetant 212
PARTB Interactions between Receptors in Synaptic Membranes in
the Central Nervous System
Chairman: J.P. Changeux 221
18. On the Role of Receptor-Receptor Interactions in Synaptic
Transmission: Biochemical and Autoradiographical Studies on the
Interactions between aradrenergic and Neuropeptide Y Receptors in the
Nucleus Tractus Solitarius K. Fuxe, L.F. Agnati, A. Harfstrand,
B.B. Fredholm,M. KaliaandM. Goldstein 222
19. Aspects on the Integrative Capabilities of the Central Nervous System:
Evidence for 'Volume Transmission' and its Possible Relevance for
Receptor-Receptor Interactions L.F. Agnati, K. Fuxe, E. MerloPich,
M. Zoli, I. Zini, F. Benfenati, A. H arfstrand and M. Goldstein 236
CONTENTS vii
20. Radioautographic Approaches to the Study of Receptor-Receptor
Interactions in the Central Nervous System W. Rostene,J. Besson,
E. Moyse,M. Dussaillant,M. Vial,P. KitabgiandA. Beaudet 250
21. Long-term Receptor Regulation Induced by Denervation of
Heterologous Afferent Fibers: Functional Significance J.P. Tassin,
D. Heroe, H. Simon, K. Taghzouti, M. Le Moal and]. Glowinski 260
22. Interactions between Vasoactive Intestinal Peptide and Norepinephrine,
Ergot Alkaloids and Prostanoids in Mouse Cerebral Cortex P.J. Magistretti,
M. Schorderet,P.R. HofandN. Schaad 272
PARTC Interactions between Membrane Receptors in Endocrine
and Peripheral Organs
Chairman: E. Kandel 284
23. Multiple Transduction Mechanisms Activated by the Neuropeptide
Somatostatin A. Schonbrunn 285
24. Receptor Mediated Activation of Phospholipase A2: Arachidonic Acid
and its Metabolites as Second Messengers J. Axelrod, R.M. Burch
and C.L. Jelsema 298
25. Interactions between the Modulator Adenosine and Classical
Transmitters B.B. Fredholm, C. Nordstedt, I. van der Ploeg, E. Lindgren,
J. NgandM. Jondal 308
26. Interactions between Neuropeptide Y and Noradrenaline Receptor
Mechanisms in Sympathetic Vascular Control J.M. Lundberg,]. Pernow,
A. Franco-Cereceda and A. Rudehill 318
27. New Paradigm: Autonomic Neurotransmission by Multiple Interaction
between Sites Intermittently Secreting Single Mixed Quanta L. Stjiirne 337
28. Adenosine Triphosphate: 'Pre-transmitter', Co-transmitter or
Modulator at the Skeletal Muscle? E. Heilbronn andJ. Hiiggblad 347
Session III
Receptor-Receptor Interactions in Psychoactive Drug Action
PART A Anxiolytic Drugs
Chairman: P. Greengard 362
29. Multiple Signal in GABAergic Transmission: A New Family of
Modulatory Peptides E. Costa, C. Ferrarese, A. Guidotti, M. Miyata
and I. Mocchetti 363
PARTB Antidepressant Drugs
Chairmen: P. Greengard and G. Jonsson 372
30. Different Presynaptic Receptors Modulate Neuronal Uptake and
Transmitter Release in Serotoninergic Nerve Terminals S.Z. Langer
andA.-M. Galzin 373
vm CONTENTS
31. Serotonin/Norepinephrine Receptor Interactions: Sensitivity Changes
after Antidepressants and Lesions E. Sanders-Bush and F. Sulser 387
32. Receptor Interactions in Antidepressant Neurochemical Mechanisms:
Modulation by Membrane Components N. Brunella, U. Cicerano,
A.C. Rovescalli, M. Riva, R. Galimberti, C. Franzetti and G. Racagni 398
33. Interactions of Coexisting Neurotransmitters and Effects of Chronic
Drug Treatment T. Bartfai, K. Iverfeldt, P. Serfozo and S.-0. Ogren 407
34. Are Opiates Involved in the Adaptation Processes of Dopamine
Receptors that Follow Chronic Drug Exposure? A. Groppetti, L. Rusconi,
E. ParatiandM. Parenti 418
35. GABA Receptors, Depression and Antidepressant Drug Action
G. Bartholini, K.G. Lloyd, B. Scallon, B. Zivkovic and P.L. Morselli 429
Session IV
Effects of Intracellular Messengers on the Membrane Receptors
Chairman: M.J. Berridge
36. Receptor-Receptor Interactions Mediated by Protein
Phosphorylation P. Greengard 444
37. The Molecular Logic of Presynaptic Facilitation and Inhibition
F. Belardetti, E.R. Kandel and S.A. Siegelbaum 454
38. Control of Plasma Membrane Transducing Systems by Second
Messengers and by Cellular Metabolism H. Rasmussen and P. Barrett 484
Session V
Physiological and Pharmacological Studies on Interactions
between Receptors in Synaptic Membranes
Chairman: G.R. Siggins
PART A Neurophysiological Studies 496
39. The Relationships of Receptors for Phencyclidine and Sigma Opiates
in Rat Cerebellum: An Electrophysiological Analysis B. Hoffer, M. Palmer,
E. Moore,M. KimandY. Wang 497
40. Modulation of Synaptic Potentials in situ by Specific Agonists of
Excitatory Amino Acids P.L. Herrling 507
PARTB Behavioural and Cardiovascular Studies 518
41. On the Role of Receptor-Receptor Interactions in Central
Cardiovascular Regulation: Functional Studies on the Interactions
between az-adrenergic and Neuropeptide Y Receptors in the Rat Medulla
Oblongata A. Hiirfstrand, K. Fuxe and L.F. Agnati 519
CONTENTS lX
42. Behavioral Analysis of the Functional Significance of Peptide
Transmitter Coexistences J.N. Crawley 531
Overview 545
43. Receptor Regulation and Receptor-Receptor Communication
M.D. Hollenberg 546
Index 555
The Participants
Ann Acheson Michael Berridge
Max Planck-Institute for ARC Unit of Insect Neuro
Psychiatry physiology
Klopferspitz 18 A and Pharmacology
D-8033 Martinsried Department of Zoology
Munich University of Cambridge
F,R,G Cambridge CB2 2EJ
ENGLAND
Luigi F. Agnati
Department of Human Physiology Floyd Bloom
University of Modena Division of Preclinical
Via Campi 287 Neuroscience and Endocrinology
411 00 Modena Scripps Clinic
ITALY La Jolla, CA 92037
U, S .A.
Julius Axelrod
Section on Pharmacology Claus Braestrup
Laboratory of Clinicla Science Pharmaceuticals R & D
NIMH Novo Industri A/S
Bethesda, MD 20205 DK-2880 Bagsvaerd
U.S .A. DENMARK
Tamas Bartfai Nicoletta Brunello
Arrheniuslaboratoriet Institute of Pharmacology
University of Stockholm and Pharmacognosy
Svante Arrhenius vag Via A. del Sarto 21
S-10691 Stockholm 20129 Milano
SWEDEN ITALY
Guiseppi Bartholin! Richard Cerione
Synthelabo - L.E.R.s. Department of Pharmacology
58, rue de la Glaciere Cornell University
75013 Paris New York State College of
FRANCE Veterinary Medicine
Ithaca, NY 14853-6401
Etienne Baulieu USA
Departement de Chimie Biologie
Hopital de Bicetre Jean-Pierre Changeux
78, avenue du General Leclere Neurobiologie Moleculaire
94270 Bicetre Institute Pasteur
FRANCE 75024 Paris Cedex 15
FRANCE
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