Recent Advances in Synthesis and Chemical Biology XI Symposium

82 Pages·2013·4.59 MB·English

by  Ann Mooney

Recent Advances in Synthesis
and Chemical Biology XI
Symposium
14th December 2012
’
O Flanagan Lecture Theatre
Royal College of Surgeons
in Ireland
’
123 St. Stephen s Green
Dublin 2
‘Recent Advances in Synthesis and Chemical Biology XI’
14th December 2012

The Centre for Synthesis and Chemical Biology wishes to thank the
following sponsors for their support for this symposium:

Centre for Synthesis & Chemical Biology 

“Recent Advances in Synthesis and Chemical Biology XI” 
Friday, 14th December, 2012 
Royal College of Surgeons in Ireland (RCSI), 123 St Stephens Green, Dublin 2

PROGRAMME 

08.50am‐9.00am   Opening session 
      Introduction by Professor Kevin B. Nolan, RCSI 
Welcome by Professor Patrick J. Broe, President, RCSI 

9.00am‐09.45am   Chairperson: Dr Celine Marmion, RCSI 
Professor Nick Farrell, Virginia Commonwealth University, USA  
‘How Does Platinum Enter Cells?  A Role for Heparan Sulfate Proteoglycan (HSPG) 
mediation’ 

09.45am‐10.30am  ELI LILLY LECTURE 
Chairperson: Professor Stefan Oscarson, UCD 
  Professor Ben G. Davis, University of Oxford, UK 
‘Sugars & Proteins’ 

10.30am‐11.00am  Coffee/Tea Break 

11.00am‐11.45am  WATERS LECTURE 
Chairperson: Professor Stephen Connon, TCD 
Professor Jeffrey Bode, ETH‐Zürich, Switzerland 
‘Chemical Protein Synthesis with the KAHA Ligation’ 

11.45am‐12.30pm  Chairperson: Dr Marc Devocelle, RCSI 
Professor Jonathan Clayden, University of Manchester, UK 
'Conformational Communication' 

12.30pm‐13.45pm  Lunch Break 

13.45pm‐14.30pm  INSTITUT DE RECHERCHES SERVIER LECTURE 
Chairperson: Professor Isabel Rozas, TCD 
      Dr Sophie Jackson, University of Cambridge, UK 
‘A Tangled Problem: The Structure, Function and Folding of Knotted Proteins’ 

14.30pm‐16.00pm  Poster Session.  Coffee/Tea Break 

16.00pm‐16.45pm  GLAXOSMITHKLINE LECTURE 
Chairperson: Professor Pat Guiry, UCD 
Professor Wilfred A. van der Donk, University of Illinois at Urbana‐Champaign, 
USA 
‘Posttranslational modifications in natural product biosynthesis’ 

16.45pm‐17.00pm  Closing Remarks 
Professor Pat Guiry, Director, Centre for Synthesis and Chemical Biology 

17.00pm‐18.00pm  Wine Reception  

          Investing in your future

Invited Speakers: 

Profiles

Professor Nicholas Farrell, Virginia Commonwealth University, USA
Dr. Nicholas P. Farrell is a graduate of University College Dublin. He obtained his PhD
from Sussex University and completed postdoctoral fellowships at Simon Fraser
University and The University of British Columbia. He is currently Professor of Chemistry
at Virginia Commonwealth University (VCU).
His research interests are in the broad area of bioinorganic chemistry. Specifically his
interest is in the medicinal uses of inorganic compounds and his work has included
development of antiviral and antiparasitic drugs. His major research is on platinum-based
anticancer agents, which are an important part of the anticancer drug armamentarium. Professor
The first genuinely structurally novel platinum drug to enter clinical trials in thirty years Nicholas Farrell,
(BBR3464) arose from his laboratory research. BBR3464 remains the only “non-
Virginia
classical” platinum compound to undergo human testing.
Commonwealth
Professor Farrell has written or co-edited three books in the area of platinum anticancer
University, USA
agents and medicinal inorganic chemistry. He is the author of over 200 refereed papers
and thirty review chapters. He and his collaborators have received over sixty patents
world wide from his inventions.
He was honored as Distinguished Research Scholar of Virginia Commonwealth
University for 2003-2004. He was instrumental in development of a graduate program in
Chemical Biology at VCU and is strongly interested in helping build scientific expertise and
collaboration amongst developing countries. He was the Chair of the first Gordon
Research Conference on Metals in Medicine and in October 2003 chaired the Ninth
International Symposium on Platinum Compounds in Cancer Chemotherapy, a meeting
which unites chemists, biochemists, pharmacologists and cancer clinicians. He was
Jefferson Science Fellow in The US Department of State 2010-2011. He is co-founder
and President of The Wild Geese Network of Irish Scientists, devoted to fostering
collaborations between scientists in Ireland and the rest of the world and highlighting the
success of Irish scientists abroad.
Professor Benjamin G. Davis, University of Oxford, UK
Professor Ben Davis got his B.A. (1993) and D.Phil. (1996) from the University of
Oxford. He then spent 2 years as a postdoctoral fellow in the laboratory of
Professor Bryan Jones at the University of Toronto, exploring protein chemistry
and biocatalysis.
In 1998 he returned to the U.K. to take up a lectureship at the University of
Durham. In the autumn of 2001 he moved to the Dyson Perrins Laboratory,
University of Oxford and received a fellowship at Pembroke College, Oxford.
Professor
Benjamin G.
His group's research centers on chemical biology with an emphasis on
Davis,
carbohydrates and proteins. In particular, the group's interests encompass
University of
synthesis and methodology, inhibitor design, protein engineering, drug delivery,
Oxford, UK
molecular modeling, molecular biology, and glycoscience.
This work has received the 1999 RSC Meldola medal and prize, the 2001 RSC
Carbohydrate Award sponsored by Syngenta, an AstraZeneca Strategic
Research Award, a DTI Smart Award, a Mitzutani Foundation for Glycoscience
Award, the 2002 Philip Leverhulme Prize, the 2005 Royal Society Mullard Prize
and Medal, the RSC 2005 Corday-Morgan Medal, the 2006 International
Association for Protein Structure Analysis and Proteomics Young Investigator
Award, the 2008 Wain Medal for Chemical Biology, and in 2008 he was the first
UK recipient of the American Chemical Society's Horace S. Isbell Award.

Professor Jeffrey Bode, ETH-Zürich, Switzerland

Professor Jeffrey Bode was born in 1974 near Los Angeles, California. He
studied Chemistry (B.S., 1996) and Philosophy (B.A., 1996) at Trinity University
in San Antonio, Texas. He began his graduate work at the California Institute of
Technology and moved with his research advisor, Prof. Erick Carreira, to ETH–
Zürich in 1998, where he received his Dok. Nat. Sci. in 2001. From 2001–2003,
he was a JSPS Postdoctoral Fellowship at the Tokyo Institute of Technology
with Prof. Keisuke Suzuki. In 2003, he joined the University of California, Santa
Barbara as an Assistant Professor of Chemistry and Biochemistry. In 2007, he Professor
moved to the University of Pennsylvania in Philadelphia as an Associate Jeffrey Bode,
Professor before joining ETH-Zürich in 2010 as Professor of Synthetic Organic ETH-Zürich,
Chemisty. Switzerland
Professor Bode’s research group works on the development of new reactions
and their application to the synthesis of small molecules and peptides,
shapeshifting organic molecules, molecular diagnostics, and novel materials.
His research and teaching have been recognized by several awards including
the Camille and Henry Dreyfus New Faculty Award (2003), NSF Career Award
(2004), Beckman Young Investigator Award (2006), Research Corporation
Cottrell Scholar Award (2006), David and Lucille Packard Foundation Fellowship
(2006), Alfred P. Sloan Fellowship (2007), the ACS Cope Scholar Award (2008),
and the Hirata Gold Medal (2009). He has received awards from pharmaceutical
companies including Amgen, Astrazeneca, Bristol Myers Squibb, Eli Lilly, and
Roche and was listed among the “Top 20 under 40 Brains in Science” by
Discover Magazine (2008).
Professor Jonathan Clayden, The University of Manchester, UK
Jonathan Clayden obtained his first degree and PhD from the University of
Cambridge, where he worked with Dr Stuart Warren on asymmetric synthesis
using phosphine oxide chemistry. He spent 18 months as a Royal Society
Western European Research Fellow in the laboratories of Prof. Marc Julia in
Paris, before moving in 1994 to Manchester as a Lecturer. In 2001 he was
promoted to a personal chair in Organic Chemistry.
He has been awarded the Royal Society of Chemistry's Meldola and Corday-
Morgan Medals, Hickinbottom Fellowship and Merck Prize, and he has received
Professor
research prizes from GlaxoWellcome, AstraZeneca, Pfizer and Novartis. He is
Jonathan
author of the undergraduate textbook "Organic Chemistry" (Clayden, Greeves,
Clayden, The
and Warren, 2nd edn pub OUP 2012) and of "Organolithiums, Selectivity for
University of
Synthesis" (pub Pergamon Press 2002).
Manchester,
UK
Jonathan Clayden and his research group work on the construction of molecules
with defined shapes – in particular those where control of conformation and
limitation of flexibility is important.