Table Of ContentRapid Review Series
Series Editor
Edward F. Goljan, MD
Behavioral Science, Second edition
Vivian M. Stevens, PhD; Susan K. Redwood, PhD; Jackie L. Neel, DO;
Richard H. Bost, PhD; Nancy W. Van Winkle, PhD;
Michael H. Pollak, PhD
BiochemiStry, third edition
John W. Pelley, PhD; Edward F. Goljan, MD
GroSS and developmental anatomy, third edition
N. Anthony Moore, PhD; William A. Roy, PhD, PT
hiStoloGy and cell BioloGy, third edition
E. Robert Burns, PhD; M. Donald Cave, PhD
microBioloGy and immunoloGy, third edition
Ken S. Rosenthal, PhD; Michael J. Tan, MD, FACP
neuroScience
James A. Weyhenmeyer, PhD; Eve A. Gallman, PhD
patholoGy, third edition
Edward F. Goljan, MD
pharmacoloGy, third edition
Thomas L. Pazdernik, PhD; Laszlo Kerecsen, MD
phySioloGy
Thomas A. Brown, MD
laBoratory teStinG in clinical medicine
Edward F. Goljan, MD; Karlis Sloka, DO
uSmle Step 2
Michael W. Lawlor, MD, PhD
uSmle Step 3
David Rolston, MD; Craig Nielsen, MD
Rapid Review
MicRobiology
iMMunology
and
Third EdiTion
Ken S. Rosenthal, phd
Professor
Department of Microbiology and Immunology
Northeastern Ohio Universities Colleges of Medicine and Pharmacy
Rootstown, Ohio
Adjunct Professor
FIU Herbert Wertheim College of Medicine
Florida International University
Miami, Florida
Michael J. Tan, Md, Facp
Assistant Professor of Internal Medicine
Northeastern Ohio Universities Colleges of Medicine and Pharmacy
Rootstown, Ohio
Clinical Physician
Infectious Diseases and HIV
Summa Health System
Akron, Ohio
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
RAPid Review MicRoBiology And iMMunology, iSBn: 978-0-323-06938-0
ThiRd ediTion
Copyright © 2011, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved.
no part of this publication may be reproduced or transmitted in any form or by any means, electronic or
mechanical, including photocopying, recording, or any information storage and retrieval system, without
permission in writing from the publisher. details on how to seek permission, further information about the
Publisher’s permissions policies and our arrangements with organizations such as the copyright clearance
center and the copyright licensing Agency, can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our understanding, changes in research methods, professional practices, or medical treatment
may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating
and using any information, methods, compounds, or experiments described herein. in using such
information or methods they should be mindful of their own safety and the safety of others, including
parties for whom they have a professional responsibility.
with respect to any drug or pharmaceutical products identified, readers are advised to check the
most current information provided (i) on procedures featured or (ii) by the manufacturer of each
product to be administered, to verify the recommended dose or formula, the method and duration
of administration, and contraindications. it is the responsibility of practitioners, relying on their own
experience and knowledge of their patients, to make diagnoses, to determine dosages and the best
treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors,
assume any liability for any injury and/or damage to persons or property as a matter of products liability,
negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Rosenthal, Ken S.
Rapid review microbiology and immunology / Ken S. Rosenthal, Michael J. Tan.—3rd ed.
p. ; cm.—(Rapid review)
Rev. ed. of: Microbiology and immunology / Ken S. Rosenthal, James S. Tan. 2nd ed. c2007.
includes index.
iSBn 978-0-323-06938-0
1. Medical microbiology—outlines, syllabi, etc. 2. Medical microbiology—examinations, questions, etc.
3. immunology—outlines, syllabi, etc. 4. immunology—examinations, questions, etc. 5. Physicians—
licenses—united States—examinations—Study guides. i. Tan, Michael J. ii. Rosenthal, Ken S.
Microbiology and immunology. iii. Title. iv. Title: Microbiology and immunology. v. Series: Rapid review
series.
[dnlM: 1. viruses—examination Questions. 2. Bacteria—examination Questions. 3. communicable
diseases—immunology—examination Questions. Qw 18.2 R815r 2011]
QR46.R7535 2011
616.9’041—dc22
2009045667
Acquisitions Editor: James Merritt
Developmental Editor: christine Abshire
Publishing Services Manager: hemamalini Rajendrababu
Project Manager: gopika Sasidharan
Design Direction: Steve Stave
Printed in the united States of America
last digit is the print number: 9 8 7 6 5 4 3 2 1
S P
erieS reface
The First and Second Editions of the Rapid Review Series have received high critical
acclaim from students studying for the United States Medical Licensing Examination
(USMLE) Step 1 and consistently high ratings in First Aid for the USMLE Step 1. The
new editions will continue to be invaluable resources for time-pressed students. As a
result of reader feedback, we have improved upon an already successful formula. We
have created a learning system, including a print and electronic package, that is easier
to use and more concise than other review products on the market.
SPECIAL FEATURES
Book
• Outline format: Concise, high-yield subject matter is presented in a study-friendly
format.
• High-yield margin notes: Key content that is most likely to appear on the exam is
reinforced in the margin notes.
• Visual elements: Full-color photographs are utilized to enhance your study and
recognition of key pathology images. Abundant two-color schematics and summary
tables enhance your study experience.
• Two-color design: Colored text and headings make studying more efficient and
pleasing.
New! Online Study and Testing Tool
• A minimum of 350 USMLE Step 1–type MCQs: Clinically oriented, multiple-
choice questions that mimic the current USMLE format, including high-yield
images and complete rationales for all answer options.
• Online benefits: New review and testing tool delivered via the USMLE Consult
platform, the most realistic USMLE review product on the market. Online feedback
includes results analyzed to the subtopic level (discipline and organ system).
• Test mode: Create a test from a random mix of questions or by subject or keyword
using the timed test mode. USMLE Consult simulates the actual test-taking
experience using NBME’s FRED interface, including style and level of difficulty
of the questions and timing information. Detailed feedback and analysis shows your
strengths and weaknesses and allows for more focused study.
• Practice mode: Create a test from randomized question sets or by subject or keyword
for a dynamic study session. The practice mode features unlimited attempts at
each question, instant feedback, complete rationales for all answer options, and a
detailed progress report.
• Online access: Online access allows you to study from an internet-enabled computer
wherever and whenever it is convenient. This access is activated through registration
on www.studentconsult.com with the pin code printed inside the front cover.
v
vi Series Preface
Student Consult
• Full online access: You can access the complete text and illustrations of this book
on www.studentconsult.com.
• Save content to your PDA: Through our unique Pocket Consult platform, you can
clip selected text and illustrations and save them to your PDA for study on the fly!
• Free content: An interactive community center with a wealth of additional valuable
resources is available.
P
reface
Rapid Review Microbiology and Immunology, Third Edition provides updated, relevant
material in an easy-to-read and understandable outline format, with excellent figures
and summary tables to help you SEE and REMEMBER the concepts. KEY WORDS
and CONCEPTS are highlighted to promote RAPID recognition and recall. For
RAPID study, the relevant facts for all of the microbes are summarized in tables.
TRIGGER WORDS for each of the microbes spark RAPID word associations on
exam questions and in the clinic. Case scenarios and clinical presentations are offered
to help you think in terms of the USMLE Step 1 exam. Most importantly, questions are
provided online to reinforce your knowledge and help you practice taking the exam.
These questions have been carefully written, reviewed, and edited for content to
emulate USMLE Step 1 questions. Detailed answers continue the review process.
Rapid Review Microbiology and Immunology can be an important part of your training
for the USMLE exam. Success on the exam requires more than a thorough knowledge
of the subject. As with any big challenge—a race, match, or championship game—a
positive winning attitude as well as mental, physical, and emotional preparedness are
necessary. Make sure to go into the exam strong. Good luck on the examination.
vii
This page intentionally left blank
A R
cknowledgment of evieweRs
The publisher expresses sincere thanks to the medical students and faculty who
provided many useful comments and suggestions for improving both the text and the
questions. Our publishing program will continue to benefit from the combined insight
and experience provided by your reviews. For always encouraging us to focus on our
target, the USMLE Step 1, we thank the following:
Bhaswati Bhattacharya, MD, MPH, Columbia University, Rosenthal Center for
Complementary and Alternative Medicine
Natasha L. Chen, University of Maryland School of Medicine
Patricia C. Daniel, PhD, University of Kansas Medical Center
Kasey Edison, University of Pittsburgh School of Medicine
Charles E. Galaviz, University of Iowa College of Medicine
Georgina Garcia, University of Iowa College of Medicine
Dane A. Hassani, Rush Medical College
Harry C. Kellermier, Jr., MD, Northeastern Ohio Universities College of Medicine
Joan Kho, New York Medical College
Michael W. Lawlor, Loyola University Chicago Stritch School of Medicine
Ronald B. Luftig, PhD, Louisiana State University Health Science Center
Christopher Lupold, Jefferson Medical College
Michael J. Parmely, PhD, University of Kansas Medical Science Center
Mrugeshkumar K. Shah, MD, MPH, Tulane University Medical School, Harvard
Medical School/Spaulding Rehabilitation Hospital
John K. Su, MPH, Boston University School of Medicine, School of Public Health
Ryan Walsh, University of Illinois College of Medicine at Peoria
ix
