Table Of ContentPsoriasis and Psoriatic Arthritis
Pathophysiology, Therapeutic Intervention,
and Complementary Medicine
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Psoriasis and Psoriatic Arthritis
Pathophysiology, Therapeutic Intervention,
and Complementary Medicine
Edited by
Siba P. Raychaudhuri
University of California Davis, School of Medicine
and Veterans Affairs Medical Center Sacramento, CA
Smriti K. Raychaudhuri
University of California Davis, School of Medicine
and Veterans Affairs Medical Center Sacramento, CA
Debasis Bagchi
University of Houston College of Pharmacy, Houston, TX, USA
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Library of Congress Cataloging‑in‑Publication Data
Names: Raychaudhuri, Siba P., editor. | Kundu-Raychaudhuri, Smriti K., editor. |
Bagchi, Debasis, 1954- editor.
Title: Psoriasis and psoriatic arthritis : pathophysiology, therapeutic intervention, and
complementary medicine / [edited by] Siba P. Raychaudhuri, Smriti K. Raychaudhuri & Debasis Bagchi.
Other titles: Psoriasis and psoriatic arthritis (Raychaudhuri)
Description: Boca Raton, FL : CRC Press/Taylor & Francis Group, 2018. |
Includes bibliographical references.
Identifiers: LCCN 2017036704 | ISBN 9781498756068 (hardback)
Subjects: | MESH: Psoriasis--therapy | Arthritis, Psoriatic--therapy | Psoriasis--epidemiology |
Arthritis, Psoriatic--epidemiology | Complementary Therapies
Classification: LCC RL321 | NLM WR 205 | DDC 616.5/26--dc23
LC record available at https://lccn.loc.gov/2017036704
Visit the Taylor & Francis Web site at
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To my late beloved friend and colleague, Pinaki Ranjan Khan
(Bhaduri). I always see him in his smiling face, my great friend,
philosopher, and guide. May Almighty God bless him always.
Debasis Bagchi
To my parents, Durga Pada and Bilwabasani Roychowdhury,
my sister, Dr. Moitrayee Roychowdhury, and my brothers,
Dr. Debi Prasad & Vwani Prasad Roychowdhury.
Siba P. Raychaudhuri
To my parents, Mrityunjoy and Uma Kundu, and to my
daughters, Blossom, Gunjari and Genea.
Smriti K. Raychaudhuri
http://taylorandfrancis.com
Contents
Preface...............................................................................................................................................xi
Editors ............................................................................................................................................xiii
Contributors .....................................................................................................................................xv
Section i Disease epidemiology and Genetics
Chapter 1 Epidemiology of Psoriasis and Psoriatic Arthritis .......................................................3
Adarsh M. B. and Aman Sharma
Chapter 2 Genetics of Psoriasis and Psoriatic Arthritis ...............................................................9
Remy Pollock and Vinod Chandran
Section ii Pathogenesis
Chapter 3 Inflammation in Psoriasis and Psoriatic Arthritis ......................................................35
Latika Gupta and Amita Aggarwal
Chapter 4 Psoriasis and Diabetes: An Unholy Alliance .............................................................45
Satinath Mukhopadhyay, Deep Dutta, and Dipyaman Ganguly
Chapter 5 Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease .......................53
Asmita Hazra and Saptarshi Mandal
Chapter 6 Multifaceted Role of Th17 Cells in Psoriatic Disease ..............................................123
Soumya D. Chakravarty
Chapter 7 Nerve Growth Factor and Its Receptor System in Rheumatologic Diseases
and Pain Management: A New Dimension in Pathogenesis and Novel Drugs
in the Pipeline ...........................................................................................................133
Smriti K. Raychaudhuri and Siba P. Raychaudhuri
Section iii Psoriatic Disease: clinical Profiles
Chapter 8 Psoriasis: Clinical Spectrum ....................................................................................149
Chelsea Ma, Smriti K. Raychaudhuri, Emanual Maverakis,
and Siba P. Raychaudhuri
vii
viii Contents
Chapter 9 Clinical Spectrum of Spondyloarthritis ...................................................................159
Joerg Ermann
Chapter 10 Comorbidities in Psoriatic Arthritis .........................................................................165
Maria J. Antonelli and Marina Magrey
Section iV-A treatment Regimen: Pharmaceuticals and treatment
Chapter 11 Current Recommendations for the Treatment of Psoriasis ......................................177
Chelsea Ma and Emanual Maverakis
Chapter 12 Management of Psoriatic Arthritis ...........................................................................195
Siba P. Raychaudhuri, Reason Wilken, Debashis Sarkar,
Emanual Maverakis, and Smriti K. Raychaudhuri
Chapter 13 Targeting IL-23/IL-17 Axis for Treatment of Psoriasis and Psoriatic Arthritis ......223
Subhashis Banerjee and Philip Mease
Chapter 14 DMARD Treatment in Patients with Psoriatic Arthritis .........................................235
Rafael Valle Oñate and Andrea Chaparro
Chapter 15 Topical Therapies for Psoriasis ................................................................................243
Michael Sticherling
Chapter 16 Overview of JAK-STAT Pathways in Spondyloarthritis ..........................................261
Smriti K. Raychaudhuri, Sanchita Raychaudhuri, Debasis Bagchi,
Anand Swaroop, and Siba P. Raychaudhuri
Chapter 17 Concept of Total Care: Multidisciplinary Approach for the Management
of Psoriatic Disease ..................................................................................................271
Smriti K. Raychaudhuri, Debasis Bagchi, and Siba P. Raychaudhuri
Section iV-B treatment Regimen: nutraceuticals in Psoriasis
Chapter 18 Nutraceutical Components in the Treatment of Psoriasis and Psoriatic Arthritis ...283
Urmila Jarouliya and Raj K. Keservani
Chapter 19 Herbal Products for the Treatment of Psoriasis........................................................299
Anna Herman and Andrzej P. Herman
Contents ix
Chapter 20 Impact of Nutrition and Dietary Supplementation on Psoriasis Pathology .............323
Odete Mendes, Mithila Shitut, and Jayson Chen
Commentary Psoriasis and Psoriatic Arthritis: Pathophysiology, Therapeutic Intervention,
and Complementary Medicine .............................................................................335
Smriti K. Raychaudhuri, Debasis Bagchi, and Siba P. Raychaudhuri
Index ..............................................................................................................................................337
Description:Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. In psoriasis, lesions skin cells, keratinocytes, grow too quickly, resulting in thick, white, silvery or red patches on skin. Normal skin cells grow gradually and
