Protein, Energy and Their Interaction in Critically Ill Children

235 Pages·2010·2.55 MB·English

Protein, Energy and Their Interaction
in Critically Ill Children
Sascha Cornelis Antonius Theodorus Verbruggen
The studies as presented in this thesis were financially supported by the Sophia
Children’s Hospital Fund (SSWO; grant 537; institutional grant, Erasmus MC – Sophia
Children’s Hospital, Rotterdam, The Netherlands). The grant supplier had no involve-
ment whatsoever in the study design, in the collection, analysis, and the interpretation
of data, and in the decision to submit the reports for publication.
The printing of this thesis was financially supported by Nutricia Advanced Medical
Nutrition, Nestlé Nutrition and Cambridge Isotope Laboratories, Inc.
ISBN: 978-90-8559-168-9
Layout: Optima Grafische Communicatie, Rotterdam, The Netherlands
Cover: Sascha Verbruggen, Arnold van den Berg; www.fotoberg010.nl
Printed by: Optima Grafische Communicatie, Rotterdam, The Netherlands
Copyright: S.C.A.T. Verbruggen , The Netherlands, 2010
All rights reserved. No part of this book may be reproduced, stored in a retrieval sys-
tem, or transmitted, in any form or by any means, electronic, mechanical, photocopy-
ing, recording, or otherwise, without the prior written permission of the holder of the
copyright.
Protein, Energy and Their Interaction
in Critically Ill Children
Eiwit, Energie en Hun Interactie
in Kritisch Zieke Kinderen
Proefschrift
ter verkrijging van de graad van doctor
aan de Erasmus Universiteit Rotterdam
op gezag van de rector magnificus
Prof. Dr. H.G. Schmidt
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 22 december 2010 om 15.30 uur
door
Sascha Cornelis Antonius Theodorus Verbruggen
geboren te Nijmegen
Promotiecommissie:
Promotor: Prof. Dr. J.B. van Goudoever
Co-promotor: Dr. K.F.M. Joosten
Overige leden: Prof. Dr. A.J. van der Heijden
Prof. Dr. D. Tibboel
Prof. Dr. P.J.J. Sauer
“The less you know, the more you believe...”
‘last night on earth’
Bono, U2
Dit boek is voor mijn ouders

Table of contents
11..
22..
33..
44..
55..
66.. Chapter 1 General introduction and outline of the thesis 9
77..
Part I Glucose metabolism
88..
99.. Chapter 2 Insulin therapy in the Pediatric Intensive Care Unit 27
1100.. Chapter 3 Efficacy and safety of a tight glucose control protocol in critically 53
1111.. ill term infants
1122.. Chapter 4 Reducing glucose intake safely prevents hyperglycemia in 65
1133.. post-surgical infants
1144..
Part II Amino Acid metabolism
1155..
1166.. Chapter 5 Ontogeny of methionine utilization and splanchnic uptake in 85
1177.. critically ill children
1188..
Chapter 6 Parenteral amino acid intakes in critically ill children; a matter of 109
1199..
convenience
2200..
Part III Protein and Energy interactions
2211..
2222..
Chapter 7 Current recommended parenteral protein intakes do not 133
2233..
support protein synthesis in critically ill septic, insulin resistant
2244.. adolescents with tight glucose control
2255..
Chapter 8 Albumin synthesis rates in critically ill infants and adolescents; 157
2266..
influence of amino acids, energy, and insulin
2277..
2288.. Part IV General discussion & summary
2299..
Chapter 9 General discussion and future perspectives 177
3300..
Chapter 10 Summary 205
3311..
Chapter 11 Samenvatting voor niet-medici 211
3322..
3333.. Dankwoord 221
3344..
Curriculum vitae 227
3355..
Affiliation of co-authors 229
3366..
3377.. List of publications 231
3388..
Portfolio 233
3399..
77

Chapter 1
General introduction
and
Outline of the thesis
“In all maladies, those who are well nourished do best”
Hippocrates, (460-377 BC.)