protein and amino acid metabolism in copd

306 Pages·2017·13.09 MB·English

R
e
n
a
t UITNODIGING
e
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o
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k Voor het bijwonen
e
r — van de openbare
P verdediging van het
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proefschrift
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IN Protein and amino
A acid metabolism
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D in COPD
A
New insights using
M
I stable tracer
N
O methodology
A
C
ID door
M
E
T Renate Jonker
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B
O
Woensdag
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IS 13 september 2017
M om 10.00 uur
I
N
C In de Aula van de
O Universiteit Maastricht
P
D Minderbroedersberg 4-6
— te Maastricht
N www.promotiewijzer.nl/
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in
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ig Aansluitend bent u
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ts van harte welkom op
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s PROTEIN AND AMINO ACID de receptie
in
g
s
ta METABOLISM IN COPD Paranimfen
ble Miranda Jonker
t Gerdien Ligthart-Melis
r
a New insights using stable
c
e
r
m tracer methodology
e Renate Jonker
t
h Omring 13
o
d 1702 NB
o
lo Heerhugowaard
g [email protected]
y
Renate Jonker
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PPRROOTTEEIINN AANNDD AAMMIINNOO AACCIIDD
MMEETTAABBOOLLIISSMM IINN CCOOPPDD

NNeeww iinnssiigghhttss uussiinngg ssttaabbllee ttrraacceerr mmeetthhooddoollooggyy

RReennaattee JJoonnkkeerr

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PROTEIN AND AMINO ACID

METABOLISM IN COPD

The studies presented in this thesis were performed at the Center for Transla-
New insights using stable tracer methodology
tional Research in Aging & Longevity (CTRAL) at the Department of Health &
Kinesiology, Texas A&M University, College Station, TX, USA, and the Donald
W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Lit-
tle Rock, AR, USA. Financial support was received from the National Heart, Lung
and Blood Institute (RO1HL095903), National Center for Research Resources
(S10RR027047, 1UL1RR029884), ESPEN Research Fellowship, and UAMS Re-
PROEFSCHRIFT
search Endowment Fund.

ter verkrijging van de graad van doctor aan de Universiteit Maastricht,
ISBN 978-94-6299-643-4
op gezag van de Rector Magnificus, Prof. dr. Rianne M. Letschert

volgens het besluit van het College van Decanen,
Cover: J. Jonker
in het openbaar te verdedigen
Printing: Ridderprint BV, the Netherlands
op woensdag 13 september 2017 om 10.00 uur

Printing and distribution of this thesis was financially supported by Maastricht

University, NUTRIM School of Nutrition and Translational Research in Metabo-

lism, Chiesi Pharmaceuticals BV, Fresenius Kabi Nederland BV, Nutricia Re-

search, Cambridge Isotope Laboratories Inc, and Nestlé Health Science.
door

B B
Renate Jonker
H
B

B B

B B
Copyright © 2017 R Jonker, Maastricht
H
B
All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval
H Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy
system, or trBansmitted in any form or by anyB means, electronic, mechanical, pho-
tocopying, recording or otherwise, without prior written permission of the cor-
B B
responding jHournals or the author.
B
B
B
B B
B B
H
B
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B
B
H Where Nutrition Becomes Therapy H Where Nutrition Becomes Therapy
B B
Where Nutrition Becomes Therapy
Where Nutrition Becomes Therapy
PROTEIN AND AMINO ACID

METABOLISM IN COPD

The studies presented in this thesis were performed at the Center for Transla-
New insights using stable tracer methodology
tional Research in Aging & Longevity (CTRAL) at the Department of Health &
Kinesiology, Texas A&M University, College Station, TX, USA, and the Donald
W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Lit-
tle Rock, AR, USA. Financial support was received from the National Heart, Lung
and Blood Institute (RO1HL095903), National Center for Research Resources
(S10RR027047, 1UL1RR029884), ESPEN Research Fellowship, and UAMS Re-
PROEFSCHRIFT
search Endowment Fund.

ter verkrijging van de graad van doctor aan de Universiteit Maastricht,
ISBN 978-94-6299-643-4
op gezag van de Rector Magnificus, Prof. dr. Rianne M. Letschert

volgens het besluit van het College van Decanen,
Cover: J. Jonker
in het openbaar te verdedigen
Printing: Ridderprint BV, the Netherlands
op woensdag 13 september 2017 om 10.00 uur

Printing and distribution of this thesis was financially supported by Maastricht

University, NUTRIM School of Nutrition and Translational Research in Metabo-

lism, Chiesi Pharmaceuticals BV, Fresenius Kabi Nederland BV, Nutricia Re-

search, Cambridge Isotope Laboratories Inc, and Nestlé Health Science.
door

B B
Renate Jonker
H
B

B B

B B
Copyright © 2017 R Jonker, Maastricht
H
B
All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval
H Where Nutrition Becomes Therapy Where Nutrition Becomes Therapy
system, or trBansmitted in any form or by anyB means, electronic, mechanical, pho-
tocopying, recording or otherwise, without prior written permission of the cor-
B B
responding jHournals or the author.
B
B
B
B B
B B
H
B
14752_RJonker_BW.indd 3 09-08-17 10:48
B
B
H Where Nutrition Becomes Therapy H Where Nutrition Becomes Therapy
B B
Where Nutrition Becomes Therapy
Where Nutrition Becomes Therapy
Promotoren

Prof. dr. Annemie M.W.J. Schols

Prof. dr. Nicolaas E.P. Deutz

Copromotor

Dr. Mariëlle P.K.J. Engelen

Beoordelingscommissie

Prof. dr. Emiel F.M. Wouters (voorzitter)

Prof. dr. Luc J.C. van Loon
Prof. dr. Steven W.M. Olde Damink

Dr. ir. Peter J.M. Weijs (Vrije Universiteit Amsterdam)

Prof. dr. Robert R. Wolfe (University of Arkansas for Medical Sciences)

Aan: mijn ouders

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Promotoren

Prof. dr. Annemie M.W.J. Schols

Prof. dr. Nicolaas E.P. Deutz

Copromotor

Dr. Mariëlle P.K.J. Engelen

Beoordelingscommissie

Prof. dr. Emiel F.M. Wouters (voorzitter)

Prof. dr. Luc J.C. van Loon
Prof. dr. Steven W.M. Olde Damink

Dr. ir. Peter J.M. Weijs (Vrije Universiteit Amsterdam)

Prof. dr. Robert R. Wolfe (University of Arkansas for Medical Sciences)

Aan: mijn ouders

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TABLE OF CONTENTS PART 5 General Discussion
Chapter 9 General discussion 249
PART 1 General Introduction & Aims
Chapter 1 General introduction & aims 11 PART 6 Summary

Summary 273
PART 2 Protein & Amino Acid Supplementation
Samenvatting 279
Chapter 2 Hydrolyzed casein and whey protein meals comparably 33

stimulate net whole-body protein synthesis in COPD pa-
tients with nutritional depletion without an additional PART 7 Appendices
effect of leucine co-ingestion
Valorisation 289

Chapter 3 Effectiveness of essential amino acid supplementation in 59
Dankwoord 295
stimulating whole body net protein anabolism is compa-

rable between COPD patients and healthy older adults
Publications & awards 299

Chapter 4 Whole body protein anabolism in COPD patients or 89
Curriculum Vitae 301
healthy older adults is not enhanced by the addition of

either carbohydrates or leucine to a serving of protein

PART 3 Aspects of the Protein Anabolic Response to Feeding
Chapter 5 Preserved protein anabolic threshold and capacity as es- 123
timated by a novel stable tracer approach suggests no
anabolic resistance and/or increased requirements in
weight stable COPD patients

Chapter 6 A critical evaluation of the anabolic response after bolus 151
or continuous feeding in healthy older adults and COPD
patients

PART 4 Alterations in the Metabolism of Individual Amino Acids
Chapter 7 Alterations in whole body arginine metabolism in 191
chronic obstructive pulmonary disease

Chapter 8 Comprehensive metabolic flux analysis in patients with 215
chronic obstructive pulmonary disease

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TABLE OF CONTENTS PART 5 General Discussion
Chapter 9 General discussion 249
PART 1 General Introduction & Aims
Chapter 1 General introduction & aims 11 PART 6 Summary

Summary 273
PART 2 Protein & Amino Acid Supplementation
Samenvatting 279
Chapter 2 Hydrolyzed casein and whey protein meals comparably 33

stimulate net whole-body protein synthesis in COPD pa-
tients with nutritional depletion without an additional PART 7 Appendices
effect of leucine co-ingestion
Valorisation 289

Chapter 3 Effectiveness of essential amino acid supplementation in 59
Dankwoord 295
stimulating whole body net protein anabolism is compa-

rable between COPD patients and healthy older adults
Publications & awards 299

Chapter 4 Whole body protein anabolism in COPD patients or 89
Curriculum Vitae 301
healthy older adults is not enhanced by the addition of

either carbohydrates or leucine to a serving of protein

PART 3 Aspects of the Protein Anabolic Response to Feeding
Chapter 5 Preserved protein anabolic threshold and capacity as es- 123
timated by a novel stable tracer approach suggests no
anabolic resistance and/or increased requirements in
weight stable COPD patients

Chapter 6 A critical evaluation of the anabolic response after bolus 151
or continuous feeding in healthy older adults and COPD
patients

PART 4 Alterations in the Metabolism of Individual Amino Acids
Chapter 7 Alterations in whole body arginine metabolism in 191
chronic obstructive pulmonary disease

Chapter 8 Comprehensive metabolic flux analysis in patients with 215
chronic obstructive pulmonary disease

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1

PART 2

PROTEIN & AMINO ACID
SUPPLEMENTATION

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