Table Of ContentH. Sinzinger W. Rogatti (Eds.)
Prostaglandin E1
in Atherosclerosis
With 34 Figures and 30 Tables
Springer-Verlag
Berlin Heidelberg New York
London Paris Tokyo
Univ.-Doz. Dr. med. Helmut Sinzinger
University of Vienna
Atherosclerosis Research Group
Schwarzspanierstral3e 17
1090 Wien
Austria
Dr. med. Waltraud Rogatti
Sanol Schwarz GmbH
Mittelstral3e 11-13
4019 Monheim
Federal Republic of Germany
ISBN-13: 978-3-540-17240-6 e-ISBN-13: 978-3-642-71679-9
DOl: 10.1007/978-3-642-71679-9
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is payable to "Verwertungsgesellschaft Wort," Munich.
[. by Springer-Verlag Berlin Heidelberg 1986
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drug dosage and application thereof contained in this book. In every individual case the re
spective user must check its accuracy by consulting other pharmaceutical literature.
2127/3140-543210
Preface
Prostaglandins were discovered in the early 1930s following research into their
extremely potent biological effects. During the last decade especially two com
pounds sharing the same receptor on the platelet surface, the antiaggregatory
prostaglandins PGE1 and PGI2, attracted considerable interest in cardiovascular
medicine.
Since 1973 PGE has been widely used in the therapy of peripheral vascular
1
disease. Although its effects on platelet function, smooth muscle cells, vascular
wall cell lipid metabolism, red cell deformability and plasmatic coagulation are
well known, these factors altogether do not fully explain the efficacy of PG El
in the therapy of advanced atherosclerosis.
This book is the outcome of a workshop organised by Schwarz GmbH (Mon
heim, FRG) which was held at Stresa, Italy, in April 1986. The coming together
of researchers and clinicians produced a survey of the chemistry, physiology,
pharmacology and clinical efficacy of PGE which will serve as a new insight
1
into the complexity of basic and clinical applications of PGE1•
Helmut Sinzinger Waltraud Rogatti
Table of Contents
Pharmacological Actions of Prostaglandin E.
Biochemistry and Pharmacology of Prostaglandin E.:
Introductory Remarks
Ro Paoletti 3
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
On the Metabolism of Prostaglandin E. in Patients Suffering from Arterial
Occlusive Disease
Tho Simmet, Bo Ao Peskar, and Ho Ro Do Wolf 8
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Effects of Prostaglandins on Platelet Function Ex Vivo and in Animal
Thrombosis Models
H. K. Breddin and W. Weichert 13
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Different Effects of E- and I-Type Prostaglandins on Human Platelet and
Polymorphonuclear Cell Function
K. Schror and Go Hecker 22
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Effects of Prostaglandin E. on Low Density Lipoprotein Receptor Activity
and Cholesterol Synthesis in Freshly Isolated Human Mononuclear
Leukocytes
Wo Krone, Ao Klass, H. Nagele, Bo Behnke, and H. Greten 32
0 0 0 0 0 0 0 0 0
Inhibition of Mitotic and Proliferative Activity of Smooth Muscle Cells
by Prostaglandin E.
Ho Sin zinger 39
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
The Effect of Intra-Arterial and Intravenous Prostaglandin E. in a Model
of Ischaemia in Healthy Volunteers
Go Rudofsky 49
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
VIII Table of Contents
Clinical Results with Prostaglandin El
Prospective Open Pilot Study to Investigate the Effects of Intermittent
Intra-Arterial Infusion Treatment with Prostaglandin El in Patients with
Intermittent Claudication
A. Creutzig, L. Caspary, and K. Alexander . ......... . 57
Treatment of Stage lIb Peripheral Arterial Occlusive Disease
with Short-Term Intra-Arterial Infusion of Prostaglandin El
W. Hach, B. W. Zanke, G. Sauerwein, and Y. Ozen . .... . 66
Clinical Efficacy of Intra-Arterial PGE -Infusion in Intermittent
1
Claudication: A Double-Blind Study
J. Blume, K. U. Rilhlmann, and H. Kiesewetter ...... . 75
Prostaglandin El in Arterial Occlusive Disease in Stages III
and IV According to Fontaine
H.-P. Bruch, M. Hor/, and A. Herold 81
Long-Term Intravenous Infusion of PGE in Peripheral Arterial Blood
1
Flow Disorders: Results of an Open Screening Study with Patients in
Fontaine's Stages III and IV
H. Heidrich. H. Dimroth. M. Gutmann, J. Helmis, A. Peters. and J. RaI?ft 92
Experiences with PGE in Patients with Phlegmasia Coerulea Dolens
1
and in Ergotism
J. D. Gruss . .................. . 99
PGE in Patients with Macular Degeneration
1
H. Heidrich, H. Harnisch and J. Ranft 106
Subject Index . . . . . . . . . . . . . . . 111
List of Contributors
Alexander, K., Prof. Dr.
Abteilung fUr Angiologie, Zentrum Innere Medizin und Dermatologie,
Medizinische Hochschule Hannover, Konstanty-Gutschow-Straf3e 8,
3000 Hannover 61, Federal Republic of Germany
Behnke, B., Dr.
I. Medizinische Kernklinik und Poliklinik, Universitats-Krankenhaus Eppen
dorf, Martinistraf3e 52, 2000 Hamburg 20, Federal Republic of Germany
Blume, J., Dr.
Gemeinschaftspraxis, Katschhof 3,5100 Aachen, Federal Republic of Germany
Breddin, H. K., Prof. Dr.
Abteilung fUr Angiologie, Zentrum der Inneren Medizin,
1. W. Goethe-Universitat, Theodor-Stern-Kai 7, 6000 Frankfurt/Main 70,
Federal Republic of Germany
Bruch, H.-P., Privat-Dozent Dr.
Chirurgische Klinik und Poliklinik, Universitat Wiirzburg,
losef-Schneider-StraBe 2, 8700 Wiirzburg, Federal Republic of Germany
Caspary, L., Dr.
Abteilung fUr Angiologie, Zentrum Innere Medizin und Dermatologie,
Medizinische Hochschule Hannover, Konstanty-Gutschow-Straf3e 8,
3000 Hannover 61, Federal Republic of Germany
Creutzig, A., Prof. Dr.
Abteilung fUr Angiologie, Zentrum Innere Medizin und Dermatologie,
Medizinische Hochschule Hannover, Konstanty-Gutschow-Straf3e 8,
3000 Hannover 61, Federal Republic of Germany
Dimroth, H., Dr.
Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstraf3e 1,
1000 Berlin 30, Federal Republic of Germany
X List of Contributors
Greten, H., Prof. Dr.
I. Medizinische Kernklinik und Poliklinik, Universitiits-Krankenhaus Eppen
dorf, Martinistral3e 52, 2000 Hamburg 20, Federal Republic of Germany
Gruss, J. D., Dr.
Gefiil3chirurgische Abteilung, Kurhessisches Diakonissen-Krankenhaus,
Goethestral3e 85, 3500 Kassel, Federal Republic of Germany
Gutmann, M. Dr.
Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstral3e 1,
1000 Berlin 30, Federal Republic of Germany
w.,
Hach, Prof. Dr.
William-Harvey-Klinik, Am Kaiserberg 6, 6350 Bad Nauheim,
Federal Republic of Germany
Harnisch, D. Dr.
Ophthalmologische Abteilung, Gertrauden-Krankenhaus, Paretzer Stral3e 12,
1000 Berlin, Federal Republic of Germany
Hecker, G.
Pharmakologisches Institut der Universitiit Koln, Gleueler Stral3e 24,
5000 Koln 41, Federal Republic of Germany
Heidrich, H., Prof. Dr.
Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstral3e 1,
1000 Berlin 30, Federal Republic of Germany
Helmis, J.
Innere Abteilung, Franziskus-Krankenhaus, BurggrafenstraBe 1,
1000 Berlin 30, Federal Republic of Germany
Herold, A., Dr.
Chirurgische Klinik und Poliklinik, Universitiit Wiirzburg,
Josef-Schneider-Stral3e 2, 8700 Wiirzburg, Federal Republic of Germany
HorJ, M., Dr.
Chirurgische Klinik und Poliklinik, Universitiit Wiirzburg,
Josef-Schneider-Stral3e 2, 8700 Wiirzburg, Federal Republic of Germany
Kiesewetter, H., Privat-Dozent Dr. Dr.
Abteilung fUr klinische Haemostaseologie und Transfusionsmedizin,
Universitiitsklinikum, 6650 Homburg/Saar, Federal Republic of Germany
Klass, A.
I. Medizinische Kernklinik und Poliklinik, Universitiits-Krankenhaus Eppen
dorf, Martinistral3e 52, 2000 Hamburg 20, Federal Republic of Germany
List of Contributors XI
Krone, W., Privat-Dozent Dr.
I. Medizinische Kernklinik und Poliklinik, Universitiits-Krankenhaus Eppen
dorf, Martinistral3e 52, 2000 Hamburg 20, Federal Republic of Germany
Nagele, H.
I. Medizinische Kernklinik und Poliklinik, Universitiits-Krankenhaus Eppen
dorf, Martinistral3e 52, 2000 Hamburg 20, Federal Republic of Germany
(hen, Y.
William-Harvey-Klinik, Am Kaiserberg 6, 6350 Bad Nauheim,
Federal Republic of Germany
Paoletti, R., Prof. Dr.
Istituto di Farmacologia e di Farmacognosia, University of Milan, Milan,
Italy
Peskar, B. A., Prof. Dr.
Institut fUr Pharmakologie und Toxikologie, Ruhr-Universitiit Bochum,
1m Lottental, 4630 Bochum, Federal Republic of Germany
Peters, A. Dr.
Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstral3e 1,
1000 Berlin 30, Federal Republic of Germany
Ranft, J. Dr.
Innere Abteilung, Franziskus-Krankenhaus, Burggrafenstral3e 1,
1000 Berlin 30, Federal Republic of Germany
Rudofsky, G., Privat-Dozent Dr.
Innere Medizin, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40,
7900 Vim, Federal Republic of Germany
Rilhlmann, K. U. Dr.
Gemeinschaftspraxis, Katschhof 3, 5100 Aachen,
Federal Republic of Germany
Sauerwein, G. Dr.
William-Harvey-Klinik, Am Kaiserberg 6, 6350 Bad Nauheim,
Federal Republic of Germany
Schror, K., Prof. Dr.
Pharmakologisches Institut der Universitiit Kaln, Gleueler Stral3e 24,
5000 Kaln 41, Federal Republic of Germany
Simmet, Th., Dr.
Institut fUr Pharmakologie und Toxikologie, Ruhr-Universitiit Bochum,
1m Lottental, 4630 Bochum, Federal Republic of Germany
XII List of Contributors
Sinzinger, H., Univ. Doz. Dr.
Atheroskleroseforschungsgruppe Wien, Schwarzspanierstral3e 17, 1090 Wien,
Austria
Weichert, W. Dr.
Abteilung fur Angiologie, Zentrum der Inneren Medizin,
1. W. Goethe-Universitat, Theodor-Stern-Kai 7, 6000 Frankfurt/Main 70,
Federal Republic of Germany
Wo(f, H. R. D. Privat-Dozent Dr.
Abteilung fUr Innere Medizin, Diakonissen-Krankenhaus, Diakonissen
stral3e 28, 7500 Karlsruhe 51, Federal Republic of Germany
Zanke, B. W. Dr.
William-Harvey-Klinik, Am Kaiserberg 6, 6350 Bad Nauheim,
Federal Republic of Germany
