Problems of Drug Dependence, 2006 : proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.

2007·10.3 MB·English

by  College on Problems of Drug Dependence (U.S.). Scientific Meeting (68th : 2006 : Orlando, Florida)

RC
563.2
C65
2006 National Institute on Drug Abuse
Problems of Drug
Dependence 2006:
Proceedings of the
68th Annual Scientific
Meeting
The College on Problems
of Drug Dependence, Inc.

Problems of Drug Dependence 2006:
Proceedings of the 68th Annual Scientific
Meeting, The College on Problems
of Drug Dependence, Inc.
Editor:
William L. Dewey, Ph.D.
Virginia Commonwealth University
NATIOMAl iTcs health
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MAR
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BLDG 10, 10 CENTER DR
8ETHES0A. MD 20892-1150
NIDA Research Monograph 187
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
National Institute on Drug Abuse
6001 Executive Boulevard
Bethesda, MD 20892
ACKNOWLEDGEMENT
The College on Problems ofDrug Dependence, Inc., an independent, nonprofit
organization conducts drug testing and evaluations for academic institutions, government,
and industry. This monograph is based on papers orpresentations from the 68th Annual
Scientific Meeting ofthe CPDD, held in Scottsdale, Arizona, June 17-22, 2006. In the
interest ofrapid dissemination, it is published by the National Institute on Drug Abuse in
its Research Monograph series as reviewed and submitted by the CPDD.
Dr. William L. Dewey, Department ofPharmacology and Toxicology, Virginia
Commonwealth University was the editor ofthis monograph.
COPYRIGHT STATUS
The National Institute on Drug Abuse has obtained permission from the copyright holders
to reproduce certain previouslypublished materials as noted in the text. Further
reproduction ofthis copyrighted material is permitted only as part ofa reprinting ofthe
entire publication or chapter. For any otheruse, the copyright holder’s permission is
required. All othermaterial in this volume except quoted passages from copyrighted
sources is in the public domain and may be used orreproduced without permission from
the Institute orthe authors. Citation ofthe source is appreciated.
Opinions expressed in this volume are those ofthe authors and do not necessarily reflect
the opinions or official policy ofthe National Institute on Drug Abuse or any other part of
the Department ofHealth and Human Services.
The U.S. Government does not endorse or favor any specific commercial product or
company. Trade, proprietary, or companynames appearing in this publication are used
onlybecause they are considered essential in the context ofthe studies reported herein.
NIH Publication No. 07-6201
Printed June 2007
NIDA Research Monographs are indexed in the Index Medicus. They are selectively
included in the coverage ofAmerican Statistics Index, BioSciences Information Service,
ChemicalAbstracts, Current Contents, PsychologicalAbstracts, and
PsychopharmacologyAbstracts,
BOARD OF DIRECTORS
Kathryn A. Cunningham, PhD, President Toby K. Eisenstein, PhD
Warren Bickel, PhD, Past-President Sari Izenwasser, PhD
Thomas R. Kosten, MD, President-Elect Herbert D. Kleber, MD
Dorothy K. Hatsukami, PhD, Treasurer Horace H. Loh, PhD
Leslie Amass, PhD A. Thomas McLellan, PhD
James C. Anthony, PhD S. Stevens Negus, PhD
Nancy A, Ator, PhD Alison Oliveto-Beaudoin, PhD
Anna Rose Childress, PhD Linda J. Porrino, PhD
MD
Thomas J. Crowley, Sharon Walsh, PhD
William L. Dewey, PhD
EXECUTIVE OFFICER
Martin W. Adler, PhD
SCIENTIFIC PROGRAM COMMITTEE
Sharon Walsh, PhD, Chair
Martin W. Adler, PhD, ex officio
Ellen B. Geller, MA, ex officio
Patrick Beardsley, PhD
Anna Rose Childress, PhD
Scott Hemby, PhD
Arthur Horton, EdD
MD
Gary B. Kaplan,
Anthony Liguori, PhD
Edythe London, PhD
Athina Markou, PhD
S. Michael Owens, PhD
Linda J. Porrino, PhD
Sandra Welch, PhD
111

TABLE OFCONTENTS
CPDD PROGRAM 1-62
REPORT FROM NATIONAL INSTITUTE ON DRUG ABUSE
NoraD. Volkow 63-67
NATHAN B. EDDY MEMORIAL AWARD RECIPIENTS 68
INTRODUCTION OF THE NATHAN B. EDDY MEMORIAL AWARD RECIPIENT
MichaelKuhar 69-70
NATHAN EDDY MEMORIAL AWARD LECTURE
B.
F. Ivy Carroll 71-85
MARIAN W. FISCHMAN LECTURESHIP RECIPIENTS 86
INTRODUCTION OF THE MARIAN W. FISCHMAN MEMORIAL AWARD
Stephen G. Holtzman 87-88
MARIAN W. FISCHMAN: RESEARCH LEGACY
LindaDykstra 89-99
ANNUAL REPORTS
BIOLOGICAL EVALUATION OF COMPOUNDS FOR THEIRPHYSICAL DEPENDENCE
POTENTIAL AND ABUSE LIABILITY. XXVI. DRUG EVALUATION COMMITTEE OF THE
COLLEGE ON PROBLEMS OF DRUG DEPENDENCE
(2004)
Andy Coop 100-112
EVALUATION OF NEW COMPOUNDS FOR OPIOID ACTIVITY
(2004)
John R. Traynor, William Fantegrossi, andJamesH. Woods 113-135
DEPENDENCE STUDIES OF NEW COMPOUNDS IN THE RHESUS MONKEY,RAT
AND MOUSE
(2004)
MarioD. Aceto, EdwardR. Bowman, LouisS. Harris, LarryD. Hughes
Barbara. R. Kipps, Shannon L. Lobe andEveretteL. May 136-164
AUTHOR INDEX. 165
SUBJECT INDEX 166-173
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Sunday, June 18, 2006
Plenary Session
Welcome
KathrynA. Cunningham, CPDD President
Reportfrom theNationalInstitute onDrugAbuse
NoraD. Volkow, Director, NIDA
Presentation oftheDistinguishedServiceAwardtoRichardM. EisenbergandJonathan B. Kamien
Introductionby Kathryn A. Cunningham
Presentation oftheMediaAwardtoHarvey Weiss
IntroductionbyMarc J. Kaufinan
Presentation oftheMentorshipAwardtoJames C. Anthony
Introductionby HowardD. Chilcoat
Presentation oftheJ. MichaelMorrisonAwardtoJosephFrascella
Introductionby LindaJ. Porrino
Presentation oftheJoseph Cochin YoungInvestigatorAwardtoR. ChristopherPierce
Introductionby Conan Kometsky
PresentationoftheNathanB. EddyAwardtoF. IvyCarroll
IntroductionbyMichaelKuhar
NathanB. EddyAwardLecture
F. Ivy Carroll
POSTER SESSION MARIJUANA/CANNABINOIDS
I -
Discriminativestimulus effects of 9-THCin C57BL/6Jmice
B. C. Ginsburg(2) andL. R. McMahon(l), (1) Department ofPharmacology, and(2) DepartmentofPsychiatry,
UniversityofTexasHealth Sciences Center, SanAntonio, TX
Thecannabinoid(CB)I receptorantagonistAM251 doesnotalterIVmethamphetamine-inducedreinstatementof
leverpressinginrats
S.Y. Boctor(l), J.L. Martinez(l) andC.P. France(2), (1) CajalNeuroscience Institute, and (2) Universityof
Texas Health Science Centerat San Antonio, SanAntonio, TX
Cue-inducedmarijuana cravingin medication development: Specificityofthemodel
L. H. Lundahl, L. A. Cederlind andC. E. Johanson, Wayne StateUniversity School ofMedicine,Detroit, MI
Comparison ofcannabis andnicotinewithdrawalfollowingrecentquitattempts
A. J. Budney(l), R. G. Vandrey(2) andJ. R. Hughes(3), (1) University ofArkansas forMedical Sciences, Little
Rock, AR(2)Johns HopkinsUniversity School ofMedicine, Baltimore, MD and (3) UniversityofVermont,
VT
Burlington,
Treatmentofcannabis-dependenttreatmentseekers: A double-blindcomparison ofnefazodone, bupropion and
placebo
D. McDowell(l,2), F. R. Levin(l,2), D. J. Brooks(2), K. Carpenter(l,2)andF. Garawi(2), (l)Columbia
University and (2)New York State Psychiatric Institute, NewYork, NY
An adaptivestepped-careapproachforreducingmarijuana use inmethadone maintenancepatients
K. J. Neufeld, R. Bums, M. KidorfandR. K. Brooner, JohnsHopkins University School ofMedicine,
MD
Baltimore,
A comparison ofcocaine- andmarijuana-dependentsubjectspresentingformedicationtreatmenttrials
A. McRae(l), S. L. Hedden(l), R. J. Malcolm(l), R. E. Carter(2) and K. T. Brady(l), (1) Departmentof
Psychiatry, and (2) Biostatistics, Bioinformatics, and Epidemiology, Medical University ofSouth Carolina,
Charleston, SC
1
Whydo cannabis usersquit?Results ofapilotstudy in 20German outpatienttreatmentfacilities
R. Noack, E. Hoch, J. Henker, H. Rohrbacherand H. U. Wittchen, University ofTechnology Dresden,
Dresden, Germany
Genderdifferences in the experienceofspontaneous cannabisquitting
M. L. Copersino(l,2), S. J. Boyd(2), D. P. Tashkin(3), M. A. Huestis(2), S. J. Heishman(2), J. C. Dermand(3),
M. S. Simmons(3) andD. A. Gorelick(2), (1) McLean Hospital/HarvardMedical School, Belmont, MA, (2)
MD
NIH/NIDA Intramural Research Program, Baltimore, and(3) David Geffen School ofMedicine, UCLA,
Los Angeles, CA
Short-term impactofsame intensitybutdifferentduration interventionforcannabis users
F. S. Jungerman and R. Laranjeira, UNIAD-Alcohol andDrugResearch UnitfromUNIFESP Federal
University ofSao Paulo, Sao Paulo, Brazil
Ispretreatmentassessmenttherapeutic? Change in marijuana useamongcannabis-dependenttreatmentseekers
duringtheclinicaltrialevaluationperiod
M. Chicurel(l), D. J. Brooks(l) andF. R. Levin(l,2), (1)NewYork State Psychiatric Institute and (2)
ColumbiaUniversity, NewYork, NY
Does behavioralinhibition increase theriskofsubstance use disorders?
H. Rohrbacher, M. Hoefler, E. Hoch, J. Henker, R. NoackandH. Wittchen, InstitutofClinical Psychology and
Psychotherapy, TechnischeUniversitaet Dresden, Dresden, Germany
Usingan offspring-of-twins design to examinethe impactofparentaldivorceon offspringearlynicotine and
cannabis use andproblems
J. D. Grant(l), A. C. Heath(l), J. F. Scherrer(l,2), A. E. Duncan(l,3), M. Waldron(l), J. R. Haber(4), T.
Jacob(4) and K. K. Bucholz(l), (1) Washington University School ofMedicine, (2) St. Louis VAMC, and(3)
SaintLouis University, St. Louis, MO; and(4) PaloAlto VAHCS, Menlo Park, CA
Determinants ofracialdiscrimination in adulthoodanditsrelationtofrequencyofcocaine andmarijuanadrug use
G. BreedenandM.E. Ensminger, CenterforResearch onEthnicity, University ofMichigan, Ann Arbor, MI
MD
andJohns Hopkins Bloomberg School ofPublic Health, Baltimore,
Marijuana arrests: Influences ofethnicity, gender, bluntsvs.joints, andmarijuanaetiquette
G. Ream, B. D. Johnson, A. Golub andE. Dunlap, Special Populations Research,National Developmentand
Research Institutes, New York, NY
Cannabis use in the community-adverseoutcomes andunmetneeds
J. Henker, E. Hoch, A. Guenther, R. Noack, H. RohrbacherandH. Wittchen, C. Schuetz, University of
Technology Dresden, Dresden, Germany
Marijuana use andexpectancies’associationwith risktaking
J. Metrik, T. Tevyaw, J. Tidey, S. Colby, D. Rohsenow,N. Barnett, C. KahlerandP. Monti, CenterforAlcohol
and Addiction Studies, Brown University, Providence, RI
Predictors ofmarijuana use amongmarriedcouples: The influence ofone’sspouse
G. G. Homish(l), K. E. Leonard(l,2) andJ. R. Comelius(3), (1) Research Institute on Addictions, and (2)
DepartmentofPsychiatry, University atBuffalo, The State University ofNewYork, Buffalo, NY and (3)
University ofPittsburgh, Pittsburgh, PA
Predictors andcorrelates ofthehazardous usesubtype ofDSM-IVcannabis abuse
E. L. Ogbum, K. Keyes andD. S. Hasin, NewYork State Psychiatric Institute, New York, NY
Problems in dependentandnon-dependentdaily cannabis users
M. Earleywine andA. Looby, UniversityatAlbany, State University ofNewYork, Albany, NY
Measurementproperties oftheDSM-IVsubstancedependence andabuse criteria
A.J. Baillie, M.R. Teesson andK. Richardson, Macquarie University, andNational DrugandAlcohol Research
Centre, University ofNew South Wales, Sydney, New South Wales, Australia
PSYCHIATRIC COMORBIDITY
I
Enhancingtreatmentadherencein comorbidbipolarandaddictive disorders: Treatmentdevelopmentandpilot
testing
I. M. Salloum(l), A. Douaihy(l), T. M. Kelly(l), D. C. Daley(l), J. R. Comelius(l,2) andL. Kirisci(2), (1)
University ofPittsburgh School ofMedicine, and(2) UniversityofPittsburgh, Pittsburgh, PA
Cannabis-usingschizophreniapatients treatedwith atypicalneuroleptics: Do theirsymptoms differfrom thatof
cannabis abstainers?
M. Schaub, R. StohlerandD. Ladewig, Centre for SubstanceUse Diseases, Research Group on Substance Use
Disorders, PsychiatricUniversityHospital Zurich, Zurich, Switzerland
Marijuanause anddepression amongadults: Testingforcausalassociations
V. Harder(l), A. R. Morral(2) andJ. Arkes(3), (1) Johns Hopkins University, Baltimore, MD, (2) The RAND
Corporation, Arlington, VA and(3) The RAND Corporation, Santa Monica, CA
2