Principles and Practice of Gynecologic Oncology

1559 Pages·2017·49.24 MB·English

by  Dennis Chi

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SEVENTH EDITION
PRINCIPLES AND
PRACTICE OF
GYNECOLOGIC
ONCOLOGY
Dennis S. Chi, MD
Deputy Chief
Head of Ovarian Cancer Surgery
Gynecology Service
Department of Surgery
Memorial Sloan Kettering Cancer Center
New York, New York
Andrew Berchuck, MD
Director
Division of Gynecologic Oncology
Department of Obstetrics and Gynecology
Director
Gynecologic Cancer Program
Duke Cancer Institute
Duke University Medical Center
Durham, North Carolina
Don S. Dizon, MD, FACP
Clinical Co-Director
Gynecologic Oncology
Massachusetts General Hospital Cancer Center
Associate Professor
Harvard Medical School
Boston, Massachusetts
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Catheryn Yashar, MD
Professor
Chief of Breast and Gynecologic Services
Medical Director La Jolla
University of California, San Diego
San Diego, California
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Seventh edition
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Printed in China
Library of Congress Cataloging-in-Publication Data
Names: Chi, Dennis S., editor. | Berchuck, Andrew, editor. | Dizon, Don S.,
editor. | Yashar, Catheryn M., editor.
Title: Principles and practice of gynecologic oncology / [edited by] Dennis
S. Chi, Andrew Berchuck, Don S. Dizon, Catheryn Yashar.
Description: Seventh edition. | Philadelphia: Wolters Kluwer Health, [2017]
| Includes bibliographical references and index.
Identifiers: LCCN 2016048223 | ISBN 9781496380395
Subjects: | MESH: Genital Neoplasms, Female
Classification: LCC RC280.G5 | NLM WP 145 | DDC 616.99/465—dc23 LC record available at
https://lccn.loc.gov/2016048223
This work is provided “as is,” and the publisher disclaims any and all warranties, express or
implied, including any warranties as to accuracy, comprehensiveness, or currency of the content
of this work.
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This work is no substitute for individual patient assessment based upon health care
professionals’ examination of each patient and consideration of, among other things, age, weight,
gender, current or prior medical conditions, medication history, laboratory data, and other factors
unique to the patient. The publisher does not provide medical advice or guidance, and this work
is merely a reference tool. Health care professionals, and not the publisher, are solely responsible
for the use of this work, including all medical judgments, and for any resulting diagnosis and
treatments.
Given continuous, rapid advances in medical science and health information, independent
professional verification of medical diagnoses, indications, appropriate pharmaceutical selections
and dosages, and treatment options should be made and health care professionals should consult
a variety of sources. When prescribing medication, health care professionals are advised to
consult the product information sheet (the manufacturer’s package insert) accompanying each
drug to verify, among other things, conditions of use, warnings, and side effects and identify any
changes in dosage schedule or contraindications, particularly if the medication to be administered
is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted
under applicable law, no responsibility is assumed by the publisher for any injury and/or damage
to persons or property, as a matter of products liability, negligence law or otherwise, or from any
reference to or use by any person of this work.
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Dedication
T
his book is dedicated to our families: Hae-Young Chi and children Jessica, Stephanie, and Andrew Chi; Amy
Berchuck and children Samuel, Jacob, and Benjamin Berchuck; Henry Stoll and children Isabelle, Harrison, and
Sophia Dizon-Stoll; Arnold Yashar and children William, Jacob, and Drew Yashar. Their patience, good humor,
encouragement, and love have inspired us throughout our careers. In this regard, they have each made significant
contributions to this book.
We would also like to express our gratitude to our own esteemed professors who guided and mentored us, and to all of
the colleagues we have worked alongside, learned from, and taught over the years. The Gynecologic Oncology community
that the readers of this book belong to is dedicated to the advancement of knowledge in the field and its application to
outstanding patient care. The considerable progress we have achieved together in the understanding, diagnosis, treatment,
and prevention of these cancers is presented in this book. On behalf of the Gynecologic Oncology community, we
dedicate this edition of Principles and Practice of Gynecologic Oncology to the brave and courageous patients we all
serve, and take inspiration in the oath we all share.
HIPPOCRATIC OATH
I swear to fulfill, to the best of my ability and judgment, this covenant:
I will respect the hard-won scientific gains of those
physicians in whose steps I walk, and gladly share such
knowledge as is mine with those who are to follow.
I will apply, for the benefit of the sick, all measures which
are required, avoiding those twin traps of overtreatment and
therapeutic nihilism.
I will remember that there is art to medicine as well as
science, and that warmth, sympathy, and understanding may
outweigh the surgeon's knife or the chemist’s drug.
I will not be ashamed to say “I know not,” nor will I fail
to call in my colleagues when the skills of another are
needed for a patient’s recovery.
I will respect the privacy of my patients, for their problems
are not disclosed to me that the world may know. Most
especially must I tread with care in matters of life and
death. Above all, I must not play at God.
I will remember that I do not treat a fever chart, a
cancerous growth, but a sick human being, whose illness may
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affect the person’s family and economic stability. My
responsibility includes these related problems, if I am to
care adequately for the sick.
I will prevent disease whenever I can, for prevention is
preferable to cure.
I will remember that I remain a member of society, with
special obligations to all my fellow human beings, those
sound of mind and body as well as the infirm.
If I do not violate this oath, may I enjoy life and art,
respected while I live and remembered with affection
thereafter. May I always act so as to preserve the finest
traditions of my calling and may I long experience the joy of
healing those who seek my help.
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International Editorial Board
Ali Ayhan, PhD
Professor and Chairman
Department of Gynecologic Oncology
Baskent University School of Medicine
Ankara, Turkey
Uziel Beller, MD
Professor and Chairman
Department of Gynecology
Shaare Zedek Medical Center
The Hebrew University of Jerusalem
Jerusalem, Israel
Prof. Adriana Bermudez, MD, PhD
Chair, Gynecologic Oncology Unit
Buenos Aires University Hospital
Buenos Aires, Argentina
Dr. Jorge A. Brañes, MD
Profesor Asociado
División de Obsteticia y Ginecología
Facultad de Medicina
Pontificia Universidad Católica de Chile
Santiago, Chile
Luis M. Chiva, MD, PhD
Head of Department of Gynecology Oncology
President of the Educational Committee
Departments of Gynecologic and Medical Oncology
The University of Texas MD Anderson Cancer Center
Madrid, Spain
Adjunct Professor of University of Texas
Houston, Texas
Dr. Carien L. Creutzberg, MD
Professor of Radiation Oncology
Department of Radiation Oncology
Leiden University Medical Centre
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Leiden, The Netherlands
Lynette Denny, MBChB, MMEDm, PhD, FCOG (SA)
Professor and Head of Obstetrics and Gynaecology
University of Cape Town/Groote Schuur Hospital
Cape Town, South Africa
Gustavo Ferraris, MD, PhD
Academic Director
Radiation Oncology Specialty
Catholic University of Córdoba
Medical Director
Department of Radiation Therapy
Centro Médico Dean Funes
Córdoba, Argentina
Michael L. Friedlander, PhD, FRACP
Conjoint Professor of Medicine
Department of Medicine
University of New South Wales
Sydney, Australia
Keiichi Fujiwara, MD, PhD
Professor and Director
Gynecologic Oncology
Saitama Medical University International Medical Center
Hidaka-City, Saitama, Japan
Dr. Paweł Knapp, MD, PhD
Professor
Department of Gynaecology and Gynaecologic Oncology
Medical University of Bialystok
Bialystok, Poland
Alexandra Leary, MD, PhD
Medical Oncologist
Gynecology Unit
Lead, Gynecology Translational Research Laboratory
Gustave Roussy Cancer Centre
Villejuif, France
Helen MacKay, MBChB, BSc, MRCP, MD
Head, Division of Medical Oncology & Hematology
Sunnybrook Odette Cancer Centre
Associate Professor
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