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P
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T
EST®
Clinical Vignettes
for the USMLE Step 1
PreTest® Self-Assessment and Review
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Notice
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P
RE
T
EST®
Clinical Vignettes
for the USMLE Step 1
PreTest® Self-Assessment and Review
Second Edition
McGraw-Hill
Medical Publishing Division
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DOI: 10.1036/0071418148
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Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Block 1 50 questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Block 2 50 questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Block 3 50 questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Block 4 50 questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Block 5 50 questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
Block 6 50 questions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
Block 7 50 questions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135
Block 8 50 questions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Block 1 Answers,Explanations,and References. . . . . 181
Block 2 Answers,Explanations,and References. . . . . 201
Block 3 Answers,Explanations,and References. . . . . 219
Block 4 Answers,Explanations,and References. . . . . 237
Block 5 Answers,Explanations,and References. . . . . 253
Block 6 Answers,Explanations,and References. . . . . 271
Block 7 Answers,Explanations,and References. . . . . 291
Block 8 Answers,Explanations,and References. . . . . 311
Bibliography. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
v
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Preface
The current format of the United States Medical Licensing Examination
(USMLE) Step 1 emphasizes clinical vignettes as the primary test ques-
tions. The examination is 400 questions, broken into eight blocks of 50
questions each. Examinees have one hour to complete each block.
Clinical Vignettes for the USMLE Step 1: Second Editionparallels this for-
mat. The book contains 400 clinical-vignette-style questions covering the
basic sciences and assembled based on the published content outline for
the USMLE Step 1. The questions are divided into eight blocks of 50 ques-
tions. As on the Step 1 exam, each block tests the examinee in all basic sci-
ence areas. Halfway through each block, a stopwatch set at 30 minutes is
included to remind the examinee of the one-hour limit. Answers are in the
second half of the book. Each answer is accompanied by a concise but
comprehensive explanation and is referenced to a key textbook and/or
journal article for further reading.
The questions in this book were culled from the nine PreTest® Basic
Science books. The publisher acknowledges and thanks the following
authors for their contributions to this book:
Anatomy, Histology, & Cell Biology: Robert Klein, Ph.D. and
James C. McKenzie, Ph.D.
Behavioral Sciences: Michael H. Ebert, M.D.
Biochemistry & Genetics: Golder Wilson, M.D.
Microbiology: Richard C. Tilton, Ph.D.
Neuroscience: Alan Siegel, Ph.D. and Heidi Siegel, M.D.
Pathology: Earl Brown, M.D.
Pathophysiology: Maurice Mufson, M.D.
Pharmacology: Arnold Stern, M.D., Ph.D.
Physiology: James C. Ryan, Ph.D. and Michael Wang, Ph.D.
McGraw-Hill
August 2001
vii
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P
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EST®
Clinical Vignettes
for the USMLE Step 1
PreTest® Self-Assessment and Review
