Population in Pharmacokinetics, Professor Leon Aarons

57 Pages·2015·1.34 MB·English

Population Pharmacokinetics
and Pharmacodynamics
as a Tool in Drug Development
Leon Aarons
Manchester Pharmacy School
University of Manchester
Pharmacokinetics
and
Pharmacodynamics
Clinical Pharmacokinetics
Pharmacokinetics Pharmacodynamics
Dosage Plasma Site of
Effect
Regimen Concentration Action

Models

The type of model to be developed should be
driven by the available information and the
goal of the simulations
Information Goal
Category
needed
Extrapolation in
Explanatory
Rich
complex and
variable environment
Mechanistic
models
Semi-mechanistic
models
Interpolation in
Empirical
Descriptive
models “Poor” simple and
stable environment
Days Months Years
100
10
C(t) = C e−λ1t +C e−λ2t
1 2
n
o
i
t
a
r
t
n 1
e
c
n
o
c
0.1
0.01
0 2 4 6 8 10
time