Phytoestrogens in functional foods

309 Pages·2006·10.401 MB·English

by  Fatih Yildiz

PHYTOESTROGENS in
FUNCTIONAL FOODS
© 2006 by Taylor & Francis Group, LLC
PHYTOESTROGENS in
FUNCTIONAL FOODS
Edited by
Fatih Yildiz
Middle East Technical University
Ankara, Turkey
Boca Raton London New York
A CRC title, part of the Taylor & Francis imprint, a member of the
Taylor & Francis Group, the academic division of T&F Informa plc.
© 2006 by Taylor & Francis Group, LLC
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Contents
Part I Production
1 Introduction to Phytoestrogens.....................................................3
E. Gültekin and Fatih Yildiz
2 Biosynthesis of Polyphenol Phytoestrogens in Plants.............19
G. Dinelli, A. Bonetti, S. Elementi, L.F.D’Antuono, and
P. Catizone
3 Chemistry and Mechanism of Action of Phytoestrogens........81
Rakesh Kumar Rishi
Part II Consumption
4 Pharmacokinetics of Phytoestrogens..........................................99
Devarakonda R. Krishna and Masuram Somashekhar
5 Phytoestrogens in Cell Signaling.............................................123
Ozgur Kutuk and Huveyda Basaga
6 Phytoestrogens and Body Composition...................................153
V. Di Mattei, L. Scalfi, and F. Branca
Part III Risk and Benefit Analysis
7 Reproductive Hormones in Females and Hormone
Replacement Therapy.................................................................169
Ayhan Karakoç and Metin Arslan
8 Benefits and Risks of Phytoestrogens......................................209
Bensu Karahalil
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Part IV Optimization and Utilization
9 Soy Isoflavones and Health.......................................................243
Xing-Gang Zhuo, Koko Taku, Melissa K. Melby, and
Shaw Watanabe
Part V Applications
10 Wine Antioxidants/Phytoestrogens...........................................265
Stamatina Kallithraka
Glossary of Terms and Abbreviations in
Phytoestrogen Research......................................................................291
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Preface
The phenolics or polyphenols include a wide range of plant secondary met-
abolic substances possessing in common an aromatic ring with one or more
hydroxyl groups; these compounds, located in the vacuole, tend to be water-
soluble, as they occur in combined forms with sugars as heterosides.
Polyphenols are major bioactives found in fruits, vegetables, cereals,
legumes, seeds, nuts, herbs, spices, chocolate, and beverages such as tea,
coffee, or wine. They possess antioxidant, phytoestrogenic, antiproliferative,
and enzyme-modulating activities in the human metabolic system. Scientific
studies from different disciplines strongly suggest a role in the prevention
of degenerative diseases such as cancers, cardiovascular diseases, osteoporo-
sis, and neurodegenerative diseases.
The pace of the polyphenol research has increased rapidly over the past 6
years. However, clinical and epidemiological evidence on their protective
effects is still limited, and optimal levels and forms of intake have not been
established. Furthermore, some questions about their safety have also been
raised. This is especially important in view of the growing number of new
food products specifically designed as sources of polyphenols.
Phytoestrogens include flavonoids (isoflavones, coumestans, prenyl fla-
vonoids) and nonflavonoids (lignans, stilbenes, phytosterols, saponins,
resorcyclic acid), which are all polyphenolic compounds.
Phytoestrogens represent one of many important bioactive nonnutrients
found in many plants commonly consumed in human diet. Knowledge of the
chemical composition of foods is fundamental for the planning of human nutri-
tion. Qualitative and quantitative data are essential when this information is
applied to prevent and control diseases for individuals and populations.
Phytoestrogens are naturally occurring chemicals of plant origin that pos-
sess weak estrogenic properties due to their structural similarities to the
human hormone estradiol. Bearing a structural resemblance to 17β-estradiol,
they can interfere in vivo with mechanisms controlled by the hormone
through competition for its receptors. They bind the estrogen receptor and
exert hormonal and antihormonal effects. In addition, phytoestrogens may
be important antioxidants. They perturb the action of DNA topoisomerase
II and ribosomal S6 kinase, which could explain their observed effects on
cell cycle, differentiation, proliferation, and apoptosis. Moreover, genistein
is a potent tyrosine kinase inhibitor. It has been proposed that through such
mechanisms phytoestrogens protect against a wide range of ailments, includ-
ing breast, prostate, bowel, and other cancers, cardiovascular diseases,
osteoporosis, and menopausal symptoms. Of the flavonoids group of phy-
toestrogens, coumestan and isoflavone classes possess the greatest estrogenic
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activity. Since coumestans are found predominantly in clover and alfalfa
plants and so are rarer components of the human diet, genistein, which has
been reported to have the most potent anticarcinogenic and estrogenic effect
among isoflavones, attracts a great deal of interest in current studies.
Despite a large amount of research, the role of phytoestrogens in human
health and diseases has not been defined. Epidemiological evidence and
experimental data from animal studies are not conclusive; beneficial effects
of phytoestrogens on human health are suggestive, but the clinical data to
support such effects are not widely available. There is a need for large-scale
clinical studies.
There has been an attempt to bring together key information from many
fields developed over the last 20 years. But controversial subjects, single case
reports or single research results, and commercial documents have been
omitted from the main text of the chapters.
The objective of this book is to introduce, organize, and document the
scientific, technical, and practical aspects involved with the production, con-
sumption, and safety of phytoestrogens in foods. This volume is designed
to serve as a reference book for students, researchers, government officials,
and manufacturers of baby foods, functional foods, and dietary supplements.
On the other hand, this book will be a good reference book for food chem-
istry, nutrition, therapeutic nutrition, pharmacology, pediatrics, obstetric,
gynecology, biochemistry, and toxicology graduate and undergraduate
courses.
The contributors to this volume have been very carefully selected from all
over the world of science for their distinguishing publications in this field.
This book is an attempt to integrate all aspects of phytoestrogen research
in one volume in a concise manner, something that is not currently available
in any other book.
If I have been able to summarize the current knowledge and stimulate
further research, I think we will all feel successful.
I thank all of the contributors to this volume and all the individuals who
helped make this timely book a reality. I especially wish to thank Anita
Lekhwani, Erika Dery, and Susan Lee B. for their assistance during the
preparation of this book.
Fatih Yildiz
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Contributors
H. Adlercreutz Institute for Preventive Medicine, Nutrition, and Cancer,
Folkhälsan Research Center, University of Helsinki, Helsinki, Finland
Metin Arslan School of Medicine, Department of Endocrinology and
Metabolism, Gazi University, Ankara, Turkey
Huveyda Basaga Faculty of Engineering and Natural Sciences, Sabanc
University, Tuzla, Istanbul, Turkey
A. Bonetti Department of Agroenvironmental Science and Technology,
University of Bologna, Bologna, Italy
Francesco Branca INRAN, Rome, Italy
P. Catiozone Department of Agroenvironmental Science and Technology,
University of Bologna, Bologna, Italy
L.F. D’Antuono Department of Agroenvironmental Science and
Technology, University of Bologna, Bologna, Italy
G. Dinelli Department of Agroenvironmental Science and Technology,
University of Bologna, Italy
S. Elementi Department of Agroenvironmental Science and Technology,
University of Bologna, Bologna, Italy
E. Gültekin Ministry of Agriculture, Office of International Relations,
Ankara, Turkey
B. Karahalil Faculty of Pharmacy, Toxicology Department, Gazi
University, Ankara, Turkey
S. Kallithraka Wine Institute, Likovrisi, Athens, Greece
Ayhan Karakoc School of Medicine, Department of Endocrinology and
Metabolism, Gazi University, Ankara, Turkey
D. R. Krishna Cancer, Aging and Metabolism Research Division, Kakatiya
University, Warangal, India
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Ozgur Kutuk Faculty of Engineering and Natural Sciences, Sabanc
University, Tuzla, Istanbul, Turkey
V. Di Mattei INRAN, Rome, Italy
Melissa K. Melby Faculty of Biosciences, Department of Nutrition Science,
Tokyo University of Agriculture, Setagaya, Tokyo, Japan
R. K. Rishi Ministry of Health and Family Welfare, Office of Drugs
Controller General, New Delhi, India
L. Scalfi University of Napoli, Napoli, Italy
M. Somashekhar Cancer, Aging and Metabolism Research Division,
Kakatiya University, Warangal, India
Koku Taku Faculty of Applied Bioscience, Department of Nutrition
Science, Tokyo University of Agriculture, Setagaya, Tokyo, Japan
Shaw Watanabe National Institute of Health and Nutrition, Shinjuku,
Tokyo, Japan
Fatih Yildiz Food Engineering Department, Middle East Technical
University, Ankara, Turkey
Xing-Gang Zhuo Faculty of Applied Bioscience, Department of Nutrition
Science, Tokyo University of Agriculture, Setagaya, Tokyo, Japan
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Acknowledgments
This work is a synergictic product of many minds who did research on
phytoestrogens during the last 20 or so years. I am grateful for the inspiration
and wisdom of many researchers in this field.
I am especially grateful for the contributing authors for their excellent
works:
Dr. Dinelli, Mr. Rishi, Dr. Krishna, Dr. Basaga, Dr. Branca, Dr. Karakoc,
Dr. Karahalil, Dr. Watanabe, Dr. Stamatina, without their help and their trust
in science this book would never be a reality.
I am also grateful for many students, friends, and colleagues at the
University of Maryland, the University of Minnesota, and the Middle East
Technical University.
I would like to thank the publishing company and their personnel for their
contribution to the dissemination of science to the world.
Finally, I feel a deep sense of gratitute to my family, my wife, and my
children, who gave me the peace of mind to enable me to really focus on
the book.
© 2006 by Taylor & Francis Group, LLC