Pharmacology: With STUDENT CONSULT Online Access

1739 Pages·2009·83.69 MB·English

by  George M. Brenner PhD

Pharmacology
Third Edition
George M. Brenner, Ph.D.
Chair and Professor Emeritus of Pharmacology, Oklahoma State
University, Center for Health Sciences, Tulsa, Oklahoma
Craig W. Stevens, Ph.D.
Chair and Professor of Pharmacology, Oklahoma State University, Center
for Health Sciences, Tulsa, Oklahoma
Copyright © 2009 Elsevier Inc.
Saunders
Front Matter
Pharmacology
THIRD EDITION
George M. Brenner, Ph.D.
Chair and Professor Emeritus of Pharmacology, Oklahoma State
University, Center for Health Sciences, Tulsa, Oklahoma
Craig W. Stevens, Ph.D.
Chair and Professor of Pharmacology, Oklahoma State
University, Center for Health Sciences, Tulsa, Oklahoma

Copyright
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PHARMACOLOGY, THIRD EDITION ISBN: 978-1-41606627-9
Copyright (c) 2010 by Saunders, an imprint of Elsevier Inc.
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Notice
Knowledge and best practice in this field are constantly changing. As new research and
experience broaden our knowledge, changes in practice, treatment and drug therapy may
become necessary or appropriate. Readers are advised to check the most current information
provided (i) on procedures featured or (ii) by the manufacturer of each product to be
administered, to verify the recommended dose or formula, the method and duration of
administration, and contraindications. It is the responsibility of the practitioner, relying on
their own experience and knowledge of the patient, to make diagnoses, to determine dosages
and the best treatment for each individual patient, and to take all appropriate safety
precautions. To the fullest extent of the law, neither the Publisher nor the Authors assume
any liability for any injury and/or damage to persons or property arising out of or related to
any use of the material contained in this book.
The Publisher
Previous editions copyrighted 2000, 2006
Library of Congress Cataloging-in-Publication Data
Brenner, George M.
Pharmacology/George M. Brenner, Craig W. Stevens. — 3rd ed.
P.; cm.
Includes bibliographical references and index.
ISBN 978-1-41606627-9
1. Pharmacology. I. Stevens, Craig W. II. Title.
[DNLM: 1. Pharmacology—methods. 2. Drug Therapy. 3.
Pharmaceutical Preparations. QV 4 B838p 2010]
RM300.B74 2010
615'.1—dc22 2008043220
Acquisitions Editor: Kate Dimock Developmental Editor: Nicole DiCicco
Production Manager: David M. Saltzberg Design Direction: Karen O'Keefe
Owens Printed in China
Last digit is the print number: 9 8 7 6 5 4 3
PREFACE
Medical pharmacology is primarily concerned with the mechanisms
by which drugs relieve symptoms and counteract the
pathophysiological manifestations of disease. It is also concerned with
the factors that determine the time course of drug action, including
drug absorption, distribution, biotransformation, and excretion.
Students are often overwhelmed by the vast amount of pharmacologic
information available today. This textbook provides the essential
concepts and information that students need to be successful in their
courses without an overwhelming amount of detail.
This text is primarily intended for students who are taking their first
course in pharmacology, but it will also be useful for those who are
preparing to take medical board or licensing examinations. Because of
the large number of drugs available today, this text emphasizes the
general properties of drug categories and prototypical drugs. Chapters
begin with a drug classification box to familiarize students with drug
categories, subcategories, and specific drugs to be discussed in the
chapter.
Throughout the book, pharmacologic information is organized in the
same format, with sections on mechanisms of action, physiologic
effects, pharmacokinetic properties, adverse effects and interactions,
and clinical uses for each drug category. Numerous illustrations are
used to depict drug mechanisms and effects, while well-organized tables
compare the specific properties of drugs within a therapeutic category.
At the end of each chapter, a summary of important points is provided
to reinforce concepts and clinical applications that are crucial for
students to remember. Review questions and selected readings are also
included to test the reader's comprehension and lead to further study.
Several changes have been incorporated into the third edition of this
text. We have revised each chapter to incorporate new drugs and drug
categories, as well as to update new findings from the pharmacology
literature on the mechanisms of action and therapeutic use.
Importantly, approved drugs that were taken off the market are
highlighted, as well as revised warnings of existing drugs added to
prescription guidelines since the last edition.
This book would not have been possible without the advice and
encouragement of mentors, colleagues, and editorial personnel. We are
especially thankful for the time and effort made by John R. Brenner,
DO, and Vivian M. Stevens, PhD, in reviewing parts of the revised text.
Finally, we are particularly appreciative to Kate Dimock and Nicole
DiCicco at Elsevier Inc. for their helpful assistance and support
throughout the production of this book.
George M. Brenner, Ph.D.
Craig W. Stevens, Ph.D.