Table Of ContentPHARMACOLOGY
Edited by Luca Gallelli
Pharmacology
Edited by Luca Gallelli
Published by InTech
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Copyright © 2012 InTech
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First published March, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Pharmacology, Edited by Luca Gallelli
p. cm.
ISBN 978-953-51-0222-9
Contents
Preface XI
Part 1 Pharmacodynamic 1
Chapter 1 Metabotropic Receptors for Glutamate and GABA 3
Gregory Stewart, Julie Kniazeff, Laurent Prézeau,
Philippe Rondard, Jean-Philippe Pin and Cyril Goudet
Chapter 2 Interactions Between Glutamate Receptors and
TRPV1 Involved in Nociceptive Processing at
Peripheral Endings of Primary Afferent Fibers 43
You-Hong Jin, Motohide Takemura,
Akira Furuyama and Norifumi Yonehara
Chapter 3 Molecular Pharmacology of Nucleoside and
Nucleotide HIV-1 Reverse Transcriptase Inhibitors 63
Brian D. Herman and Nicolas Sluis-Cremer
Chapter 4 Opioid Kappa Receptor Selective Agonist
TRK-820 (Nalfurafine Hydrochloride) 81
Hideaki Fujii, Shigeto Hirayama and Hiroshi Nagase
Chapter 5 The Cannabinoid 1 Receptor and Progenitor Cells
in the Adult Central Nervous System 99
Alexandra Sideris, Thomas Blanck and
Esperanza Recio-Pinto
Chapter 6 Peroxisome Proliferator Activated Receptor
Alpha (PPAR) Agonists: A Potential Tool for a
Healthy Aging Brain 123
Jennifer Tremblay-Mercier
Part 2 Experimental Study 141
Chapter 7 The Influence of Cyclophosphamide on
Immune Function of Murine Macrophages 143
Krzysztof Bryniarski
VI Contents
Chapter 8 Modification of Interleukin-10 with
Mannose-6-Phosphate Groups Yields a Liver-Specific
Cytokine with Antifibrotic Activity in Rats 161
Heni Rachmawati, Adriana Mattos, Catharina Reker-Smit,
Klaas Poelstra and Leonie Beljaars
Part 3 Pharmacogenetic 177
Chapter 9 Pharmacogenetics: The Scientific Basis 179
Bosun Banjoko
Chapter 10 Future of Pharmacogenetics in
Cardiovascular Diseases 207
Rianne M.F. Van Schie, Talitha I. Verhoef,
Anke-Hilse Maitland-Van Der Zee, Anthonius de Boer,
Tom Schalekamp, Felix J.M. Van Der Meer,
William K. Redekop and Rahber Thariani
Chapter 11 Warfarin Enantiomers Pharmacokinetics by CYP2C19 223
Yumiko Akamine and Tsukasa Uno
Chapter 12 Pharmacogenetics –
A Treatment Strategy for Alcoholism 231
Anjana Munshi and Vandana Sharma
Part 4 Clinical Pharmacology 255
Chapter 13 Pharmacological Approaches to Improve Ageing 257
Pedro J. Camello, Cristina Camello-Almaraz and Maria J. Pozo
Chapter 14 Pharmacological Neuromodulation in
Autism Spectrum Disorders 283
Bill J. Duke
Chapter 15 Pharmacology of Hormone
Replacement Therapy in Menopause 313
Adela Voican, Bruno Francou, Liliana Novac,
Nathalie Chabbert-Buffet, Marianne Canonico, Geri Meduri,
Marc Lombes, Pierre-Yves Scarabin, Jacques Young,
Anne Guiochon-Mantel and Jérôme Bouligand
Chapter 16 A Multi-Level Analysis of World
Scientific Output in Pharmacology 339
Carlos Olmeda-Gómez, Ma-Antonia Ovalle-Perandones
and Antonio Perianes-Rodríguez
Chapter 17 Mephedrone-Related Fatalities in the United Kingdom:
Contextual, Clinical and Practical Issues 355
John M. Corkery, Fabrizio Schifano and A. Hamid Ghodse
Contents VII
Chapter 18 Novel Strategies in Drug-Induced Acute Kidney Injury 381
Alberto Lázaro, Sonia Camaño,
Blanca Humanes and Alberto Tejedor
Chapter 19 Chemical and Physical Enhancers for
Transdermal Drug Delivery 397
José Juan Escobar-Chávez, Isabel Marlen Rodríguez-Cruz
and Clara Luisa Domínguez-Delgado
Part 5 Diagnostic 435
Chapter 20 Application of Matrix-Assisted Laser
Desorption/Ionization Imaging Mass Spectrometry 437
Nobuhiro Zaima
Chapter 21 Closed-Loop Control of Anaesthetic Effect 453
Santiago Torres, Juan A. Méndez, Héctor Reboso,
José A. Reboso and Ana León
Part 6 Ethnopharmacology and Toxicology 477
Chapter 22 The Influence of Displacement by
Human Groups Among Regions in the Medicinal
Use of Natural Resource: A Case Study in Diadema,
São Paulo - Brazil 479
Daniel Garcia and Lin Chau Ming
Chapter 23 Unconventional Raw Natural Sustainable
Sources for Obtaining Pharmacological Principles
Potentially Active on CNS Through Catalytic,
Ecologically Clean, Processes 519
Yanier Nuñez Figueredo, Juan E. Tacoronte Morales,
Alicia Lagarto Parra, Olinka Tiomno Tiomnova,
Jorge Tobella Sabater and Jorge Leyva Simeon
Chapter 24 Elucidating the Role of Biliverdin Reductase
in the Expression of Heme Oxygenase-1 as a
Cytoprotective Response to Stress 535
James R. Reed
Chapter 25 Antibothropic Action of Camellia sinensis
Extract Against the Neuromuscular Blockade by
Bothrops jararacussu Snake Venom and Its
Main Toxin, Bothropstoxin-I 569
Yoko Oshima-Franco, Luana de Jesus Reis Rosa,
Gleidy Ana Araujo Silva, Jorge Amaral Filho,
Magali Glauzer Silva, Patricia Santos Lopes,
José Carlos Cogo, Adélia Cristina Oliveira Cintra
and Maria Alice da Cruz-Höfling
VIII Contents
Chapter 26 The Effects of Viscum album (Mistletoe) QuFrF
Extract and Vincristine in Human Multiple Myeloma
Cell Lines – A Comparative Experimental Study Using
Several and Different Parameters 587
Eva Kovacs
Chapter 27 Ethanol Toxicity in the Brain:
Alteration of Astroglial Cell Function 607
Metoda Lipnik-Štangelj
Part 7 Future Applications 625
Chapter 28 The Involvement of Purinergic System in Pain:
Adenosine Receptors and Inosine as Pharmacological
Tools in Future Treatments 627
Francisney Pinto Nascimento, Sérgio José Macedo Jr.
and Adair Roberto Soares Santos
Chapter 29 Therapeutic Organometallic Compounds 651
Beril Anilanmert
Chapter 30 Aging: Drugs to Eliminate Methylglyoxal,
a Reactive Glucose Metabolite, and
Advanced Glycation Endproducts 681
Indu Dhar and Kaushik Desai
Chapter 31 Ethanol Interference on Adenosine System 709
Silvânia Vasconcelos, Sarah Escudeiro,
Ana Luíza Martin, Paula Soares, Antônio Vieira Filho,
Larissa Silva, Kátia Cilene Dias, Danielle Macêdo,
Francisca Cléa Sousa and Marta Fonteles
