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Perioperative Care of
the Cancer Patient
Carin A. Hagberg, MD Joseph L. Nates, MD, MBA, CMQ, MCCM
Chief Academic Officer Professor, Deputy Chair
The University of Texas MD Anderson Cancer Center; Director Surgical and Medical Intensive Care Units
Division Head Critical Care Department
Anesthesiology, Critical Care & Pain Medicine Division of Anesthesiology, Critical Care & Pain Medicine
The University of Texas MD Anderson Cancer Center The University of Texas MD Anderson Cancer Center
Houston, TX, USA; Houston, TX, USA
Bud Johnson Clinical Distinguished Chair
Donal J. Buggy, DSc, MD, MSc, DME,
Vijaya N. R. Gottumukkala, MBBS,
FRCPI, FFSEM, FRCA, FCAI
MD(Anes), FRCA
Professor
Professor Anaesthesiology & Perioperative Medicine
Anesthesiology & Perioperative Medicine Mater Misericordiae University Hospital, School of Medicine,
The University of Texas MD Anderson Cancer Center University College Dublin;
Houston, TX, USA Consultant
Anaesthesiology
Bernhard J. Riedel, MD, MBA, PhD Mater Misericordiae University Hospital Dublin,
Dublin, Ireland
Professor
Anesthesiology, Perioperative and Pain Medicine
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia
Elsevier
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PERIOPERATIVE CARE OF THE CANCER PATIENT ISBN: 978-0-323-69584-8
Copyright © 2023 by Elsevier Inc. All rights reserved.
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Library of Congress Control Number: 2021947605
Publisher: Sarah Barth
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Printed in India
Last digit is the print number: 9 8 7 6 5 4 3 2 1
We dedicate this issue to all of our cancer patients and their loved ones.
We find inspiration for our ongoing clinical, research, and educational
efforts from their fighting spirit, courage, strength, and hope for a cure.
Contributors
Salahadin Abdi, MD, PhD Rosalind S. Bello, MA, CPHQ
Professor and Chair Director
Pain Medicine Cancer Control Health Policy
The University of Texas MD Anderson Cancer Center The University of Texas MD Anderson Cancer Center
Houston, TX, USA Houston, TX, USA
Anoushka M. Afonso, MD Shamgar Ben-Eliyahu, PhD
Associate Attending Sagol School of Neuroscience and School of
Department of Anesthesiology & Critical Care Psychological Sciences
Memorial Sloan Kettering Cancer Center Tel-Aviv University
New York, NY, USA Tel-Aviv, Israel
Thomas A. Aloia, MD Celena Scheede Bergdahl, MSc, PhD
Professor of Surgery Professor
Surgical Oncology Department of Kinesiology and Physical Education
The University of Texas MD Anderson Cancer Center McGill University
Houston, TX, USA Montreal, Quebec, Canada
Gabriele Baldini, MD, MSc Sushma Bhatnagar, MD
Assistant Professor, Anesthesiologist Professor and Head
Anesthesia Department of Onco-Anesthesia and Palliative Medicine
McGill University Health Centre, Montreal General Institute Rotary Cancer Hospital and National
Hospital Cancer Institute
Montreal, Quebec, Canada All India Institute of Medical Sciences
New Delhi, India
Jose Banchs, MD
Associate Professor Joshua Botdorf, DO, FACP, CMQ
Cardiology Assistant Professor
The University of Texas MD Anderson Cancer Center Critical Care and Respiratory Medicine
Houston, TX, USA The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Daniel T. Baptista-Hon, BSc, MSc, PhD
Assistant Professor Christelle Botha, FANZCA
Faculty of Medicine Consultant Anatesthetist
Macau University of Science and Technology Department of Cancer Anaesthesia
Macau, SAR, China Perioperative and Pain Medicine, Peter MacCallum
Honorary Lecturer, School of Medicine Cancer Centre
University of Dundee Melbourne, Victoria, Australia
Dundee, United Kingdom
David L. Brown, MD
Karen Basen-Engquist, PhD Chief Executive Officer
Professor Curadux Inc.
Department of Behavioral Science Austin, TX, USA
Division of Cancer Prevention and Population Sciences
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
iv
Contributors v
Donal J. Buggy, DSc, MD, MSc, DME, FRCPI, FFSEM, German Corrales, MD
FRCA, FCAI Department of Anesthesiology and Perioperative Medicine
Professor The University of Texas MD Anderson Cancer Center
Anaesthesiology & Perioperative Medicine Houston, TX, USA
Mater Misericordiae University Hospital, School of
Medicine, University College Dublin Jose Cortes, MD
Consultant, Assistant Professor
Anaesthesiology Pediatrics
Mater Misericordiae University Hospital Dublin The University of Texas MD Anderson Cancer Center
Dublin, Ireland Houston, TX, USA
Kate L. Burbury, MBBS(Hons), FRACP, FRCPA, DPhil Kimberly D. Craven, MD
Deputy Chief Medical Officer Clinical Assistant Professor
Executive Department of Anesthesiology
Peter MacCallum Cancer Centre; Perioperative Care & Pain Management
Consultant Haematologist NYU Langone – Brooklyn
DHMO Brooklyn, NY, USA
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia John Wilson Crommett, MD
Associate Professor
Joseph Butler, PhD, FACS, FRCS Critical Care Medicine
Consultant Spine Surgeon The University of Texas MD Anderson Cancer Center
National Spinal Injuries Unit Houston, TX, USA
Mater Misericordiae University Hospital
Dublin, Ireland Kristin P. Crosby, MD
Fellow
Ronan Cahill, MB, BAO, BCh, FRCS, MD Pediatric Critical Care Medicine
UCD Centre for Precision Surgery New York Presbyterian Hospital – Weill Cornell Medicine
Surgery New York, NY, USA
University College Dublin
Surgery Luis Felipe Cuellar Guzman, MD
Mater Misericordiae University Hospital Anesthesiologist in Oncological Patient and Pain Medicine
Dublin, Ireland Specialist
Anesthesiology Department Head National Institute of
Franco Carli, MD, MPhil Cancer Mexico;
Professor Onco Anesthesia
Anesthesia National Institute of Cancer Mexico
McGill University Mexico City, Mexico;
Montreal, Quebec, Canada Professor Course Cancer Anesthesia Fellowship Program
National Institute of Cancer Mexico
Meghan Carton, BM, BS Anesthesiology Department
Doctor National Institute of Cancer
Anaesthetics Mexico
Mater Misericordiae University Hospital
Dublin, Ireland Anahita Dabo-Trubelja, MD, FASA
Associate Attending
Juan P. Cata, MD Anesthesiology and Critical Care
Professor Memorial Sloan Kettering Cancer Center
Department of Anesthesiology and Perioperative Medicine New York, NY, USA
The University of Texas MD Anderson Cancer Center
Houston, TX, USA Anh Quynh Dang, MD
Associate Professor
Cara Connolly, MB, BCh, BAO, LRCP & SI (Hons), MSc, Anesthesiology and Preoperative Medicine
FCAI The University of Texas MD Anderson Cancer Center
Consultant Anaesthetist Houston, TX, USA
Department of Anaesthesia
Mater Misericordiae University Hospital
Dublin, Ireland
vi Contributors
Alessandro R. De Camilli, MD Mats Enlund, MD, PhD
Assistant Attending, Anesthesiology and Critical Care Associate Professor
Medicine Centre for Clinical Research-Västerås
Anesthesiology and Critical Care Uppsala University
Memorial Sloan Kettering Cancer Center Västerås, Sweden;
New York NY, USA Senior Consultant
Department of Anaesthesia & Intensive Care
Madhavi D. Desai, DA, DNB Central Hospital
Assistant Professor and Consultant Västerås, Sweden
Department of Anaesthesia , Critical Care and Pain
Tata Memorial Hospital and Homi Bhabha National Linette Ewing, DO, MPH
Institute Assistant Professor
Mumbai, Maharashtra, India Pediatric Critical Care
The University of Texas MD Anderson Cancer Center
Jugdeep Dhesi, BSc, PhD, FRCP Houston, TX, USA
Consultant Geriatrician
Ageing and Health Dylan Finnerty, FCAI, FJFICMI, EDICM
Guy’s and St Thomas’ NHS Trust Research Fellow
London, United Kingdom; Anaesthesiology & Perioperative Medicine
Hon. Reader Mater Misericordiae University Hospital University
Kings College London College Dublin
London, United Kingdom; Dublin, Ireland
Hon. Associate Professor
University College London Joël Fokom Domgue, MD, MPH
London, United Kingdom Research Scientist
Epidemiology
Jeson R. Doctor, MD, DNB, MNAMS, MBBS The University of Texas MD Anderson Cancer Center
Professor and Consultant Anaesthesiologist Houston, TX, USA
Department of Anaesthesiology
Critical Care and Pain Tata Memorial Hospital John Frenzel, MD, MS
Homi Bhabha National Institute Director, Learning Health System
Mumbai, Maharashtra, India Institute for Cancer Care Innovation
The University of Texas MD Anderson Cancer Center
Jennifer S. Downs, MMed, FCS(SA) Houston, TX, USA
Surgical Oncology Fellow
Cancer Surgery Colleen M. Gallagher, PhD, FACHE, HEC-C
Peter MacCallum Cancer Centre Executive Director
Melbourne, Victoria, Australia Section of Integrated Ethics
The University of Texas MD Anderson Cancer Center
Julia A. Dubowitz, MBBS Professor
Specialist Anaesthetist Department of Critical Care Medicine
Department of Anaesthetics, Perioperative and The University of Texas MD Anderson Cancer Center
Pain Medicine Houston, TX, USA;
Peter MacCallum Cancer Centre Research Scholar
Clinical Fellow UNESCO Chair in Bioethics and Human Rights
Department of Critical Care Rome, Italy
University of Melbourne
Parkville, Melbourne, Australia Dorian Yarih García-Ortega, MD, MSc, FACS
Master in Musculoskeletal Tumors
German Echeverry, MD Surgeon Oncologist
Attending Physician Skin, Soft Tissue and Bone Tumors Department
Department of Anesthesiology and Critical Care Medicine National Cancer Institute
Memorial Sloan Kettering Cancer Center Mexico City, Mexico
New York, NY;
Attending Physician
Department of Anesthesia
Mount Sinai Medical Center
Miami Beach, FL, USA
Contributors vii
Michelle Gerstman, MBBS, FANZCA, MD Ernest Hawk, MD, MPH
Consultant Anaesthetist Vice President and Division Head
Anaesthetics, Perioperative Medicine and Pain Medicine Division of Cancer Prevention and Population Sciences
Peter MacCallum Cancer Centre T. Boone Pickens Distinguished Chair for Early Prevention
Melbourne, Victoria, Australia of Cancer
The University of Texas MD Anderson Cancer Center
Arunangshu Ghoshal, MD, MRes Houston, TX, USA
Assistant Professor
Palliative Medicine Alexander G. Heriot, MB BChir, MA, MD, MBA, FRACS,
Tata Memorial Hospital FRCS(Gen.), FRCSEd, FACS, FASCRS, GAICD
Homi Bhaba National Institute Director of Surgery
Mumbai, Maharashtra, India Division of Cancer Surgery
Peter MacCallum Cancer Centre
Vijaya N.R. Gottumukkala, MBBS, MD(Anes), FRCA Melbourne, Victoria, Australia
Professor
Anesthesiology & Perioperative Medicine Joseph M. Herman, MD
The University of Texas MD Anderson Cancer Center Director of Clinical Research
Houston, TX, USA Northwell Health
New Hyde Park, NY, USA
Michael P.W. Grocott, MB, BS, MD, FRCA, FRCP, FFICM
Professor Jonathan G. Hiller, MBBS, GCEpi, MAICD, FANZCA, PhD
Respiratory and Critical Care Research Theme Division of Surgical Oncology
Southampton NIHR Biomedical Research Centre Anaesthesia
University Hospital Southampton NHS Foundation Trust/ Peter MacCallum Cancer Centre
University of Southampton Parkville, Victoria, Australia;
Southampton, United Kingdom; Central Clinical School
Anaesthesia, Perioperative and Critical Care Medicine Medicine, Nursing and Health Sciences
Research Unit Monash University
University Hospital Southampton NHS Foundation Trust Prahran, Victoria, Australia
Southampton, United Kingdom
Ruth E. Hubbard, BSc, MBBS, MRCP, MSc, MD, FRACP
Carlos E. Guerra-Londono, MD Professor
Department of Anesthesiology, Pain Management, and Centre for Health Services Research
Perioperative Medicine University of Queensland
Henry Ford Health System Brisbane, Queensland, Australia
Detroit, MI, USA
Hilmy Ismail, MD, FRCA, FANZCA
Sushan Gupta, MD Consultant Anaesthetist
Department of Internal Medicine Anaesthesia and Preoperative Medicine
Carle Foundation Hospital PeterMacCallum Cancer Center
Champaign, IL, USA Melbourne, Victoria, Australia;
Senior Lecturer
David E. Gyorki, MBBS, MD, FRACS Anaesthesia
Surgical Oncologist University of Melbourne
Division of Cancer Surgery Melbourne, Victoria, Australia
Peter MacCallum Cancer Centre
Melbourne, Victoria, Australia Nelda Itzep, MD
Assistant Professor
Tim G. Hales, BSc, PhD Pediatrics
Professor of Anaesthesia The University of Texas MD Anderson Cancer Center
Institute of Academic Anaesthesia Houston, TX, USA
University of Dundee, Dundee, Scotland
United Kingdom
viii Contributors
Emily Jasper, MBBS (Hons) Faraz Khan, MB, BCh, BAO, MRCS, MD, MSc
Research Registrar Specialist Surgical Lecturer
Ageing and Health Colorectal Surgery
Guy’s and St Thomas’ NHS Foundation Trust Mater Misericordiae University Hospital
London, United Kingdom; Dublin, Ireland
Senior Registrar/Advanced Trainee
Department of Rehabilitation and Aged Care James S. Killinger, MD
North Metropolitan Health Service Medical Director, Pediatric Intensive Care Unit
Perth, Western Australia, Australia Pediatrics
Memorial Sloan Kettering Cancer Center
Saba Javed, MD Associate Professor of Clinical Pediatrics
Assistant Professor Pediatrics
Department of Anesthesiology Weill Cornell Medicine
University of Texas Medical School at Houston New York, NY, USA
Houston, TX, USA
Samantha Koschel, BMed MD, GradDipAnat
Bhawna Jha, MD, MRCPsych Urology Registrar
Interventional Pain Physician Cancer Surgery
Medical Director–Bundle Payment For Care Improvement Peter MacCallum Cancer Centre
Physician Advisor–Utilization Management and Review Melbourne, Victoria, Australia
University of Arkansas for Medical Sciences (UAMS)
Little Rock, AR, USA Alan Kotin, MD
Attending Anesthesiologist
Shaman Jhanji, MB ChB, MRCP, FRCA, FFICM, PhD Anesthesiology
Consultant in Intensive Care Medicine and Anaesthetics Memorial Sloan Kettering Cancer Center
Department of Anaesthesia, Perioperative Medicine, Pain New York, NY, USA
and Intensive Care
Royal Marsden Hospital Atul Prabhakar Kulkarni, MBBS, MD (Anesthesiology)
London, United Kingdom; Professor and Head
Team Leader/Honorary Clinical Senior Lecturer Division of Critical Care Medicine
Division of Cancer Biology Tata Memorial Hospital
Institute of Cancer Research Homi Bhabha National Institute
London, United Kingdom Mumbai, Maharashtra, India
Daryl Jones, BSc(Hons), MB BS, FRACP, FCICM, MD, Adam La Caze, BPharm, BA (Hons), PhD
PhD Senior Lecturer
Consultant Intensive Care specialist School of Pharmacy
Austin Health and Warringal hospital; The University of Queensland
Acting Deputy Director Brisbane, Queensland, Australia
Austin Department of Intensive Care;
Adjunct Professor Nathan Lawrentschuk, MBBS, FRACS Urol, PhD
University Melbourne; Professor
Adjunct Professor (Research) Director of Urology
DEPM Monash University; Royal Melbourne Hospital
Medical Director Parkville, Victoria, Australia
Critical Care Outreach Austin Hospital
Past President Lauren Adrienne Leddy, MB, BCh, BAO
International Society of Rapid Response Systems Medical Student
Melbourne, Victoria, Australia Medicine
University College Dublin
Ravish Kapoor, MD Dublin, Ireland
Associate Professor
Department of Anesthesiology and Perioperative Medicine Celia R. Ledet, MD
The University of Texas MD Anderson Cancer Center Assistant Professor
Houston, TX, USA Department of Surgical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA