Perinatal events and altered pain sensitivity in later life

154 Pages·2013·5.32 MB·English

Perinatal events and altered pain sensitivity in later life
Citation for published version (APA):
knaepen, L. (2013). Perinatal events and altered pain sensitivity in later life. [Doctoral Thesis, Maastricht
University]. BOXPress. https://doi.org/10.26481/dis.20130508lk
Document status and date:
Published: 01/01/2013
DOI:
10.26481/dis.20130508lk
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Download date: 18 Feb. 2023
Perinatal events and  
altered pain sensitivity in later life 

Liesbeth Knaepen
© Liesbeth Knaepen, Maastricht 2013 
ISBN 978‐90‐8891‐588‐8 
Cover: © Ria Jeuris 
Printed & Lay Out by: Proefschriftmaken.nl || Uitgeverij BOXPress
Perinatal events and  
altered pain sensitivity in later life 

PROEFSCHRIFT 
ter verkrijging van de graad van doctor  
aan de Universiteit Maastricht, 
op gezag van de Rector Magnificus, 
Prof. dr. L.L.G. Soete 
volgens het besluit van het College van Decanen, 
in het openbaar te verdedigen 
op woensdag 8 mei 2013 om 12:00 uur 

door  

Liesbeth Knaepen
P
ROMOTORES 
Prof. dr. E.A.J. Joosten 
Prof. dr. D. Tibboel (Erasmus MC, Rotterdam) 

C  
OPROMOTOR
Dr. J. Patijn 

B  
EOORDELINGSCOMMISSIE
Prof. dr. L.J.I. Zimmermann (voorzitter) 
Dr. T. Charlier (Ohio University, Athens Ohio) 
Prof. dr. B.W.W. Kramer 
Prof. dr. I. Reiss (Erasmus MC, Rotterdam) 
Prof. dr. H.W. Steinbusch
C
ONTENTS 

C
ONTENTS 
CHAPTER 1  General introduction                                                                                     9 

PART 1    Perinatal maternal stress exposure 
CHAPTER 2  Perinatal maternal stress: Effects on nociception in offspring            19 
CHAPTER 3  Developmental fluoxetine exposure normalizes the long‐term          41 
effects of maternal stress on post‐operative pain in offspring 

PART 2    Repetitive neonatal pain exposure 
CHAPTER 4  Repetitive neonatal pain exposure and effects on nociception          65 
in later life: Plasticity of the nociceptive network 
CHAPTER 5  Neonatal repetitive needle pricking:                                                        73 
Plasticity of the spinal nociceptive circuit and  
extended postoperative pain in later life 
CHAPTER 6  Sex differences in inflammatory mechanical hypersensitivity in        97 
later life of rats exposed to repetitive needle pricking as neonates 

CHAPTER 7  General discussion                                                                                    109 
    Summary                                                                                                     125 
Samenvatting                                                                                             129 
Co‐authors and affiliations                                                                      133 
Curriculum Vitae                                                                                       137 
List of publications                                                                                    141 
Dankwoord                                                                                                 147

A
BBREVIATIONS 

A
BBREVIATIONS 
5‐HT    5‐hydroxytryptamine or serotonin 
5‐HTT    5‐hydroxytryptamine transporter 
5‐HT‐R    5‐hydroxytryptamine receptor 
CF    Control fluoxetine 
CFA    Complete Freund’s adjuvant 
CGRP    Calcitonin gene‐related peptide 
CNS    Central nervous system 
CORT    Corticosteroid 
CV    Control vehicle 
DRG    Dorsal root ganglion 
GR    Glucocorticoid receptor 
HPA    Hypothalamic‐pituitary‐adrenal  
IHC    Immunohistochemistry 
NGF    Nerve growth factor  
NMDA     N‐methyl‐D‐aspartate 
NP    Needle prick 
NICU    Neonatal intensive care unit 
PAG    Periaqueductal gray matter 
pCPA    para‐chlorophenylalanine  
PWL    Paw withdrawal latency 
PWT    Paw withdrawal threshold 
SF    Stress fluoxetine 
SSRI    Selective serotonin reuptake inhibitor 
SV    Stress vehicle 
TC    Tactile control 
trkA    Tyrosine kinase A 
RVM    Rostral ventral medulla 
VGLUT1   Vesicular glutamate transporter 1

1
C
HAPTER 

General introduction

L. Knaepen
9