Table Of Content1600 John F. Kennedy Blvd.
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PEDIATRIC GASTROENTEROLOGY: THE REQUISITES IN PEDIATRICS ISBN: 978-0-323-03280-3
Copyright © 2008 by Mosby, Inc., an affi liate of Elsevier Inc.
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This book is dedicated to the hard-working, conscientious medical staff of The Children’s
Hospital of Philadelphia. These professionals include the physicians, nurses, fellows, residents,
and medical secretaries who have devoted their lives to the care of ill children. Although the
primary doctor typically receives praise from the patient and his or her family when an
illness is correctly diagnosed and treated, many times proper medical care would not be
possible without the effort and selfl essness put forth by the other members of the health care
team.
Contributors
Robert Baldassano, MD Patricia A. DeRusso, MD, MS
Director, Infl ammatory Bowel Disease Center, The Assistant Professor of Pediatrics, Division of Pediatric
Children’s Hospital of Philadelphia; Professor of Gastroenterology and Nutrition, Johns Hopkins
Pediatrics, University of Pennsylvania School of University School of Medicine, Baltimore, Maryland
Medicine, Philadelphia, Pennsylvania
Edwin deZoeten, MD
Dorsey Bass, MD Attending Gastroenterologist, The Children’s Hospital
Associate Professor of Pediatrics, Division of Pediatric of Philadelphia; Assistant Professor of Pediatrics,
Gastroenterology, Stanford University School of University of Pennsylvania School of Medicine,
Medicine, Stanford, California Philadelphia, Pennsylvania
Vincent Biank, MD Rosalyn Diaz, MD
Assistant Professor of Pediatrics, Department of Instructor, Department of Pediatrics, University of
Pediatrics, Division of Gastroenterology and Pennsylvania School of Medicine; Attending
Nutrition, Medical College of Wisconsin; Attending Physician, Department of Gastroenterology,
Physician, Children’s Hospital of Wisconsin, Hepatology, and Nutrition, The Children’s Hospital of
Milwaukee, Wisconsin Philadelphia, Philadelphia, Pennsylvania
Dana Boctor, MSC, MD, FRCPC Udeme Ekong, MBBS, MRCP(UK)
Clinical Assistant Professor, University of Calgary Assistant Professor of Pediatrics, Northwestern
Faculty of Medicine; Gastroenterologist, Division of University Feinberg School of Medicine; Attending
Gastroenterology and Nutrition, Alberta Children’s Physician, Pediatric Gastroenterology, Hepatology,
Hospital, Calgary, Alberta, Canada and Nutrition Division, Children’s Memorial Hospital,
Chicago, Illinois
Joseph M. Croffi e, MD, MPH
Associate Professor of Clinical Pediatrics, Indiana Karan M. Emerick, MD
University School of Medicine; Director, Pediatric GI Attending Physician, Pediatric Digestive Diseases,
Motility Laboratory, James Whitcomb Riley Hospital Connecticut Children’s Medical Center, Hartford,
for Children, Indianapolis, Indiana Connecticut
Vera De Matos, MD Joseph F. Fitzgerald, MD
Fellow in Gastroenterology, Hepatology, and Professor of Pediatrics, Indiana University School of
Nutrition, University of Pennsylvania School of Medicine; Director Emeritus, Section of Pediatric
Medicine/The Children’s Hospital of Philadelphia, Gastroenterology, Hepatology, and Nutrition, James
Philadelphia, Pennsylvania Whitcomb Riley Hospital for Children, Indianapolis,
Indiana
vii
viii Contributors
Jonathan Flick, MD Douglas Jacobstein, MD
Clinical Associate Professor of Pediatrics, University Attending Physician, Division of Pediatric
of Pennsylvania School of Medicine; Attending Gastroenterology and Nutrition, The Herman and
Physician, The Children’s Hospital of Philadelphia, Walter Samuelson Children’s Hospital at Sinai, The
Philadelphia, Pennsylvania Sinai Hospital of Baltimore, Baltimore, Maryland
Alejandro Flores, MD Muralidhar Jatla, MD
Professor of Pediatrics, Tufts University School of Instructor, Department of Pediatrics, University of
Medicine; Chief, Division of Pediatric Pennsylvania School of Medicine; Fellow, Division of
Gastroenterology and Nutrition, Floating Hospital for Gastroenterology, Hepatology, and Nutrition, The
Children, Boston, Massachusetts Children’s Hospital of Philadelphia, Philadelphia,
Pennsylvania
James P. Franciosi, MD, MS
Fellow-Physician, Division of Gastroenterology, Binita M. Kamath, MBBC
Hepatology, and Nutrition, The Children’s Hospital of Assistant Professor of Pediatrics, University of
Philadelphia, Philadelphia, Pennsylvania Pennsylvania School of Medicine; Attending
Physician, Division of Gastroenterology, Hepatology,
Joshua R. Friedman, MD
and Nutrition, The Children’s Hospital of
Attending Gastroeneterologist, The Children’s
Philadelphia, Philadelphia, Pennsylvania
Hospital of Philadelphia; Professor of Pediatrics,
University of Pennsylvania School of Medicine, Marsha Kay, MD
Philadelphia, Pennsylvania Staff Physician, Department of Pediatric
Gastroenterology and Nutrition, The Children’s
Benjamin D. Gold, MD
Hospital, Cleveland Clinic, Cleveland, Ohio
Professor of Pediatrics and Microbiology and Marcus
Professor and Director, Division of Pediatric Janice A. Kelly, MD
Gastroenterology, Hepatology and Nutrition, Clinical Assistant Professor, Department of Pediatrics,
Department of Pediatrics, Emory Children’s Center, University of Pennsylvania School of Medicine;
Emory University School of Medicine; Chief, Attending Physician, The Children’s Hospital of
Gastroenterology Service, and Medical Director, Philadelphia, Philadelphia, Pennsylvania
Gastroenterology Endoscopy and Diagnostic
Phillip P. Le, MD, PhD
Laboratory, Children’s Healthcare of Atlanta, Egleston
Resident, Doheny Eye Institute, Los Angeles,
Children’s Hospital Campus, Atlanta, Georgia
California
Andrew B. Grossman, MD
Chris A. Liacouras, MD
Instructor, University of Pennsylvania School of
Co-Director of Pediatric Endoscopy and Attending
Medicine; Fellow, Division of Gastroenterology,
Gastroenterologist, The Children’s Hospital of
Hepatology, and Nutrition, The Children’s Hospital of
Philadelphia; Professor of Pediatrics, University of
Philadelphia, Philadelphia, Pennsylvania
Pennsylvania School of Medicine, Philadelphia,
Barbara A. Haber, MD Pennsylvania
Associate Professor of Pediatrics, University of
Kathleen M. Loomes, MD
Pennsylvania School of Medicine; Attending
Assistant Professor of Pediatrics, University of
Physician, Division of Gastroenterology, Hepatology,
Pennsylvania School of Medicine; Attending
and Nutrition, The Children’s Hospital of
Physician, The Children’s Hospital of Philadelphia,
Philadelphia, Philadelphia, Pennsylvania
Philadelphia, Pennsylvania
Analice S. Hoffenberg, MD
David Mack, MD
Clinical Instructor, University of Colorado School of
Professor, Department of Pediatrics and Biochemistry,
Medicine, Denver, Colorado
Microbiology, and Immunology, University of Ottawa
Edward J. Hoffenberg, MD Faculty of Medicine; Head, Pediatric
Associate Professor of Pediatrics, University of Gastroenterology, Hepatology and Nutrition,
Colorado School of Medicine; Attending Physician, Children’s Hospital of Eastern Ontario, Ottawa,
The Children’s Hospital, Denver, Colorado Ontario, Canada
Contributors ix
Petar Mamula, MD David A. Piccoli, MD
Assistant Professor of Pediatrics, University of Professor of Pediatrics, University of Pennsylvania
Pennsylvania School of Medicine; Director, Pediatric School of Medicine; Chief, Division of
Endoscopy, The Children’s Hospital of Philadelphia, Gastroenterology, Hepatology, and Nutrition, The
Philadelphia, Pennsylvania Children’s Hospital of Philadelphia, Philadelphia,
Pennsylvania
Asim Maqbool, MD
Assistant Professor of Pediatrics, University of Michael Posencheg, MD
Pennsylvania School of Medicine; Attending Assistant Professor of Clinical Pediatrics, University of
Physician, Division of Gastroenterology, Hepatology, Pennsylvania School of Medicine; Associate Medical
and Nutrition, The Children’s Hospital of Director, Intensive Care Nursery, Hospital of the
Philadelphia, Philadelphia, Pennsylvania University of Pennsylvania, Philadelphia,
Pennsylvania
Jonathan E. Markowitz, MD
Attending Physician, Center for Digestive Health, Elizabeth Rand, MD
Greenville Children’s Hospital, Greenville, South Director, Pediatric Liver Transplant Program and
Carolina Attending Gastroenterologist, The Children’s Hospital
of Philadelphia; Associate Professor of Pediatrics,
Maria Mascarenhas, MBBS
University of Pennsylvania School of Medicine,
Associate Professor of Pediatrics, University of
Philadelphia, Pennsylvania
Pennsylvania School of Medicine; Section Chief,
Nutrition, Division of Gastroenterology, Hepatology, Matthew R. Riley, MD
and Nutrition, The Children’s Hospital of Pediatric Gastroenterologist, Legacy Emanuel
Philadelphia, Philadelphia, Pennsylvania Children’s Hospital and Providence St. Vincent’s
Medical Center, Portland, Oregon
Peter Mattei, MD
Assistant Professor of Surgery, University of Leonel Rodriguez, MD, MS
Pennsylvania School of Medicine; Attending Instructor in Pediatrics, Harvard Medical School;
Physician, Division of General, Thoracic, and Fetal Director, Pediatric Gastrointestinal Motility Program,
Surgery, The Children’s Hospital of Philadelphia, and Medical Director, Pediatric Intestinal
Philadelphia, Pennsylvania Rehabilitation Program, Massachusetts General
Hospital, Boston, Massachusetts
Randolph P. Matthews, MD, PhD
Assistant Professor of Pediatrics, University of Colin D. Rudolph, MD, PhD
Pennsylvania School of Medicine; Attending Professor of Pediatrics, Medical College of Wisconsin;
Physician, Division of Gastroenterology, Hepatology, Chief, Division of Pediatric Gastroenterology and
and Nutrition, The Children’s Hospital of Nutrition, Children’s Hospital of Wisconsin,
Philadelphia, Philadelphia, Pennsylvania Milwaukee, Wisconsin
Michael L. Nance, MD Anil Rustgi, MD
Associate Professor of Surgery, University of T. Grier Miller Professor of Medicine and Genetics
Pennsylvania School of Medicine; Attending Surgeon and Director, Center for Molecular Studies in
and John and Josephine Templeton Endowed Chair in Digestive and Liver Disease, University of
Pediatric Trauma, The Children’s Hospital of Pennsylvania School of Medicine; Chief,
Philadelphia, Philadelphia, Pennsylvania Gastroenterology Division, Hospital of the University
of Pennsylvania, Philadelphia, Pennsylvania
Peter F. Nichol, MD, PhD
Assistant Professor, University of Utah Department of Matthew J. Ryan, MD
Surgery; Pediatric Surgeon, Primary Children’s Assistant Professor of Pediatrics, University of
Medical Center, Salt Lake City, Utah Pennsylvania School of Medicine; Attending
Physician, Division of Gastroenterology, Hepatology,
Gilberto Pereira, MD
and Nutrition, The Children’s Hospital of
Professor of Pediatrics, University of Pennsylvania
Philadelphia, Philadelphia, Pennsylvania
School of Medicine; Neonatologist, The Children’s
Hospital of Philadelphia, Philadelphia, Pennsylvania
