Pediatric asthma and allergy

128 Pages·2017·7.11 MB·English

Pediatric asthma and allergy
An epidemiological approach
Ali Arabkhazaeli
Ali Arabkhazaeli
Pediatric asthma and allergy
An epidemiological approach
Copyright © 2014 Ali Arabkhazaeli
For article published or accepted for publication, the copyright has been
Ali Arabkhazaeli
transferred to the respective publisher. No part of thesis may reproduced, stored
Pediatric asthma and allergy
in a retrieval system, or transmitted in any form or by mean without the An epidemiological approach
permission of the author, or when appropriate, the publisher of the manuscript. Copyright © 2014 Ali Arabkhazaeli
For article published or accepted for publication, the copyright has been transferred to the respective publisher.
Cover design: Atrina Arabkhazaeli
No part of thesis may reproduced, stored in a retrieval system, or transmitted in any form or by mean without
Layout and printing: Off page (www.offpage.nl) the permission of the author, or when appropriate, the publisher of the manuscript.
ISBN: 978-90-393-6797-1 Cover design: Atrina Arabkhazaeli
Layout and printing: Off Page (www.offpage.nl)
The work presented in this thesis was performed at the Division of
ISBN: 978-90-393-6797-1
Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for
The work presented in this thesis was performed at the Division of Pharmacoepidemiology and Clinical
Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University,
Utrecht, The Netherlands.
The Netherlands.
Financial support for publication of this thesis by the Utrecht Institute for Pharmaceutical Sciences (UIPS),
Financial support for publication of this thesis by the Utrecht Institute for Stichting KNMP Fondsen, ChipSoft and Stichting Astma Bestrijding is gratefully acknowledged.
Pharmaceutical Sciences (UIPS), Stichting KNMP Fondsen, ChipSoft and Stichting
Astma Bestrijding is gratefully acknowledged.
Pediatric asthma and allergy
An epidemiological approach
Astma en allergie bij kinderen
Een epidemiologische aanpak
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector
magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van het college voor promoties in
het openbaar te verdedigen op maandag 26 juni 2017 des middags te 12.45 uur
door
Ali Arabkhazaeli
geboren op 22 juni 1969
te Sary, Iran
Promotoren: Prof. dr. J.A.M. Raaijmakers
Promotoren: Prof. dr. J.A.M. Raaijmakers
Prof. dr. C.K. van der Ent
Prof. dr. A.H. Maitland-van der Zee
Prof. dr. C.K. van der Ent
Copromotor: Dr. S.J.H. Vijverberg
Prof. dr. A.H. Maitland-van der Zee
Copromotor: Dr. S.J.H. Vijverberg
To my family

TABLE OF CONTENTS
Chapter 1 General introduction 9
Chapter 2 Severity of allergic symptoms in children with multiple allergic 19
diseases
Chapter 2.1 Characteristics and severity of asthma in children with and without 21
atopic conditions: a cross-sectional study

Chapter 2.2 Atopic dermatitis characteristics and medication-use patterns in 35
school-age children with atopic dermatitis and asthma symptoms
Chapter 3 Pharmacoepidemiological studies on asthma and atopic dermatitis 47
Chapter 3.1 High incidence of oral corticosteroids prescriptions in children with 49
asthma in early childhood
Chapter 3.2 Asthma treatment patterns in Dutch children 63
Chapter 3.3 Patterns of topical corticosteroids prescriptions in children who are 69
regular users of asthma medication
Chapter 4 Genetic risk factors for developing allergic diseases 81
Chapter 4.1 Association of Allergy genetic risk score with allergies in children - 83
Wheezing illnesses study Leidsche Rijn cohort
Chapter 5 General discussion 99
Appendix English summary 113
Samenvatting 115
Acknowledgements 119
List of co-authors 123
List of publications 125
About the author 127
7

chapter 1
General introduction