Pathophysiology of Respiration

85 Pages·2016·1.42 MB·English

by  Mieczyslaw Pokorski (eds.)

Advances in Experimental Medicine and Biology 884
Neuroscience and Respiration
Mieczyslaw Pokorski Editor
Pathophysiology
of Respiration
Advances in Experimental Medicine
and Biology
Neuroscience and Respiration
Volume 884
Editorial Board
Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel
N.S.AbelLajtha,KlineInstituteforPsychiatricResearch,Orangeburg,NY,USA
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Rodolfo Paoletti, University of Milan, Milan, Italy
Subseries Editor
Mieczyslaw Pokorski
Moreinformationabout thisseries athttp://www.springer.com/series/13457
Mieczyslaw Pokorski
Editor
Pathophysiology
of Respiration
Editor
MieczyslawPokorski
PublicHigherMedicalProfessionalSchoolinOpole
InstituteofNursing
Opole,Poland
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-24482-2 ISBN978-3-319-24484-6(eBook)
DOI10.1007/978-3-319-24484-6
LibraryofCongressControlNumber:2015958791
SpringerChamHeidelbergNewYorkDordrechtLondon
#SpringerInternationalPublishingSwitzerland2016
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Preface
The book series Neuroscience and Respiration presents contributions by
expert researchers and clinicians in the field of pulmonary disorders. The
chapters provide timely overviews of contentious issues or recent advances
in the diagnosis, classification, and treatment of the entire range of pulmo-
narydisorders,bothacuteandchronic.Thetextsarethoughtasamergerof
basic and clinical research dealing with respiratory medicine, neural and
chemical regulation of respiration, and the interactive relationship between
respiration and other neurobiological systems such as cardiovascular func-
tionorthemind-to-bodyconnection.Theauthorsfocusontheleading-edge
therapeutic concepts, methodologies, and innovative treatments. Pharmaco-
therapy is always in the focus of respiratory research. The action and
pharmacology of existing drugs and the development and evaluation of
new agents are the heady area of research. Practical, data-driven options to
manage patients will be considered. New research is presented regarding
older drugs, performed from a modern perspective or from a different
pharmacotherapeutic angle. The introduction of new drugs and treatment
approachesinbothadultsandchildrenalsoisdiscussed.
Lung ventilation is ultimately driven by the brain. However, neuropsy-
chologicalaspectsofrespiratorydisordersarestillmostlyamatterofconjec-
ture. After decades of misunderstanding and neglect, emotions have been
rediscovered as a powerful modifier or even the probable cause of various
somatic disorders. Today, the link between stress and respiratory health is
undeniable. Scientists accept a powerful psychological connection that can
directlyaffectourqualityoflifeandhealthspan.Psychologicalapproaches,
bydecreasingstress,canplayamajorroleinthedevelopmentandtherapyof
respiratorydiseases.
Neuromolecular aspects relating to gene polymorphism and epigenesis,
involvingbothheritablechangesinthenucleotidesequence,andfunctionally
relevantchangestothegenomethatdonotinvolveachangeinthenucleotide
sequence, leading to respiratory disorders will also be tackled. Clinical
advancesstemmingfrommolecularandbiochemicalresearcharebutpossi-
ble if the research findings are translated into diagnostic tools, therapeutic
procedures,andeducation,effectivelyreachingphysiciansandpatients.All
thatcannotbeachievedwithoutamultidisciplinary,collaborative,bench-to-
bedsideapproachinvolvingbothresearchersandclinicians.
v
vi Preface
Thesocietalandeconomicburdenofrespiratoryailmentshasbeenonthe
rise worldwide leading to disabilities and shortening of life span. COPD
alone causes more than three million deaths globally each year. Concerted
efforts are required to improve this situation, and part of those efforts are
gaining insights into the underlying mechanisms of disease and staying
abreast with the latest developments in diagnosis and treatment regimens.
Itishopedthatthebookspublishedinthisserieswillassumealeadingrolein
the field of respiratory medicine and research and will become a source of
referenceandinspirationforfutureresearchideas.
I would like to express my deep gratitude to Martijn Roelandse, Paul
Roos, and Tanja Koppejan from Springer’s Life Sciences Department for
theirgenuineinterestinmakingthisscientificendeavorcomethroughandfor
the expert management of this novel book series. My thanks also go to
Pavitra Arulmurugan from SPi Technologies India Private Ltd. for the
skillfulhandlingofthebookproductiondetails.
Opole,Poland MieczyslawPokorski
Volume 18: Pathophysiology
of Respiration
This book presents a range of research and clinical contributions,including
observational studies, practical treatment examples, diagnostic test assess-
ment,biomarkers,andsystematicreviews.Theobjectiveistoseektoexplain
the processes or mechanisms whereby abnormal or undesired conditions
develop and progress. The attention is given to disturbed carbohydrate
metabolism in perpetuation of respiratory ailments or raising therapeutic
problems. The psychosocial context of chronic respiratory conditions is
tackledaswell.Oxidativestressisconducivetobothphysicalandcognitive
aging, which raises the specter of using its biochemical markers in future
antiaging therapeutic strategies. Critical information provided in the
contributions will allow readers to make informed judgments. The book
will hopefully serve to create awareness and apprehension about the
developments in the field of pneumology and related areas of medical
research.
vii

Contents
BreathinginParkinsonismintheRat. . .. . . . . . . . . . . . .. . . . . 1
MonikaBialkowska,PawełBoguszewski,andMieczyslawPokorski
Lund-MackaySystemforComputedTomographyEvaluation
ofParanasalSinusesinPatientswithGranulomatosis
andPolyangiitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
K.Z˙ycinska,M.Straburzynski,A.Nitsch-Osuch,R.Krupa,
M.Hadzik-Błaszczyk,M.Cieplak,T.M.Zielonka,andK.Wardyn
OxidativeStressandNitricOxideinSedentaryOlderAdults
withIntellectualandDevelopmentalDisabilities. . . . . . . . . . . . 21
E.Carmeli,A.Bachar,O.Rom,andD.Aizenbud
ForeignBodyintheAirwayaFemalePatient
withMyastheniaGravis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
EwaMalinowska,JolantaDa˛browska-Kruszewska,
AnnaDoboszyn´ska,MichałStangiewicz,KarolGugała,
andMaciejBiernacki
RelevanceofImmune-SympatheticNervousSystem
InterplayfortheDevelopmentofHypertension. . . . . . . . . . . . . 37
PawelJ.Winklewski,MarekRadkowski,andUrszulaDemkow
TheInfluenceofInsulinTherapyontheCourse
ofAcuteExacerbationofBronchialAsthma. . . . . . . . . . . . . . . . 45
K.Wytrychowski,A.Obojski,andA.Hans-Wytrychowska
AssociationofAllergicRhinitisinFemaleUniversity
StudentswithSocio-economicFactorsandMarkers
ofEstrogensLevels. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
I.Wronka,K.Klis´,andK.Jarze˛bak
PsychosocialContextofDifferencesBetweenAsthmatic
andDiabeticPatientsinAdaptationtoDisease. . . . . . . . . . . . . . 61
AgnieszkaWilczyn´ska,JagodaSikora,andBeataPituła
ix